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Topic Review
Nanotechnology for Blood–Brain Barrier Crossing
Nanomedicine is currently focused on the design and development of nanocarriers that enhance drug delivery to the brain to address unmet clinical needs for treating neuropsychiatric disorders and neurological diseases. Polymer and lipid-based drug carriers are advantageous for delivery to the central nervous system (CNS) due to their safety profiles, drug-loading capacity, and controlled-release properties. Polymer and lipid-based nanoparticles (NPs) are reported to penetrate the blood–brain barrier (BBB) and have been extensively assessed in in vitro and animal models of glioblastoma, epilepsy, and neurodegenerative disease. Since approval by the Food and Drug Administration (FDA) of intranasal esketamine for treatment of major depressive disorder, intranasal administration has emerged as an attractive route to bypass the BBB for drug delivery to the CNS. NPs can be specifically designed for intranasal administration by tailoring their size and coating with mucoadhesive agents or other moieties that promote transport across the nasal mucosa.
  • 594
  • 28 Feb 2023
Topic Review
Corey-Seebach Reagent in the 21st Century
The Corey-Seebach reagent plays an important role in organic synthesis because of its broad synthetic applications. The Corey-Seebach reagent is formed by the reaction of an aldehyde or a ketone with 1,3-propane-dithiol under acidic conditions, followed by deprotonation with n-butyllithium. A large variety of natural products (alkaloids, terpenoids, and polyketides) can be accessed successfully by utilizing this reagent.
  • 594
  • 30 May 2023
Topic Review
Three Species of Lycium Genus
The genus Lycium belongs to the Solanaceae family and comprises more than 90 species distributed on diverse continents. Lycium barbarum is by far the most studied and considered to possess healthy properties. The biological properties of L. barbarum fruits are mainly attributed to polysaccharides, particularly complex glycoproteins with different compositions. In contrast, L. europaeum, L. intricatum, and L. schweinfurthii found particularly in the Mediterranean region, are poorly studied, although used by native populations. The evaluation of the chemical composition and biological, nutritional, or pharmacological properties of these species must be unveiled. Such studies will not only enrich knowledge but may also lead to the use of some of these species in food to replace L. barbarum or other plant species. Since L. europaeum, L. intricatum, L. infaustum and L. schweinfurthii generally occur in impoverished areas, the culture and transformation of these species products could contribute to the sustained enrichment of the populations living in those zones.
  • 592
  • 17 Jan 2023
Topic Review
Flavonoids Composition in Astragalus membranaceus
Astragalus membranaceus is a valuable medicinal plant species widely distributed in Asia. Its root is the main medicinal tissue rich in methoxylated flavonoids. Origin can highly influence the chemical composition and bioactivity.
  • 592
  • 09 Dec 2021
Topic Review
Sodium-Vanadium Bronze Na9V14O35
Na9V14O35 (η-NaxV2O5) has been synthesized by a solid-state route in an evacuated sealed silica tube and tested as electroactive material for Na half-cells. Being charged to 4.6 V vs. Na+/Na, almost 3 Na can be extracted per Na9V14O35 formula unit, resulting in a charge capacity of about 60 mAh g−1. Upon discharge below 1 V, Na9V14O35 uptakes Na up to the Na:V = 1:1 atomic ratio that is accompanied by a drastic increase of the separation between the layers of the VO4 tetrahedra and VO5 tetragonal pyramids, and a volume increase of about 31%. The induced structure instability triggers a transformation of the ordered layered Na9V14O35 structure into a rock-salt type disordered structure. Ultimately, the amorphous products of a conversion reaction are formed at 0.1 V, delivering the discharge capacity up to 490 mAh g−1, which, however, quickly fades with the number of charge-discharge cycles.
  • 592
  • 11 Jan 2022
Topic Review
Synthesis of Pyran Derivatives
Heterogeneous catalysis (HC) has become a valuable means for designing sustainable production protocols to obtain superior intermediates, synthons, and potent bioactive heterocycles. The heterogeneous catalysts proved economical and eco-friendly due to the effectiveness of non-hazardous metals for constructing nanomaterials for atom-economical organic reactions. Heterogeneous catalysts significantly affected scientific and industrial innovations due to their tuneable textural properties, flexible acid-base characteristics, higher thermal stability, and improved reusability, with their excellent performance over their enormous counterparts.
  • 592
  • 18 Oct 2022
Topic Review
Endocytic Properties of vGPCRs
Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. This enables cells to communicate and respond to external environments, maintain cellular homeostasis, and transduce signals. G protein-coupled receptors (GPCRs) constitute a family of receptors with seven transmembrane alpha-helical domains (7TM receptors) expressed at the cell surface, where they regulate physiological and pathological cellular processes. Several herpesviruses encode receptors (vGPCRs) which benefits the virus by avoiding host immune surveillance, supporting viral dissemination, and thereby establishing widespread and lifelong infection, processes where receptor signaling and/or endocytosis seem central. vGPCRs are rising as potential drug targets as exemplified by the cytomegalovirus-encoded receptor US28, where its constitutive internalization has been exploited for selective drug delivery in virus infected cells. Therefore, studying GPCR trafficking is of great importance.
  • 591
  • 30 Apr 2021
Topic Review
Fire Safety Performance of Polymer Composites
The growth of the use of polymer composite materials has been a phenomenon since 1960, with diverse applications in spacecraft, aircraft, boats, ship, automobiles, civil infrastructure, sporting goods, and consumer products. In addition, the use of composites will continue to grow in the coming years with emerging end-use such as large bridge structures, engine machinery, offshore platforms, computer hardware, and biomedicals devices. However, a critical challenge facing the growing use of polymer composites is their high combustibility.
  • 591
  • 02 Nov 2021
Topic Review
Manganese-Zinc Ferrite Nanoparticles
A suitable amount of an addition of zinc, manganese, cobalt or nickel to the ferrite nucleus of the Nanoparticles (NPs) results in a higher magnetic resonance imaging contrast and an increase of saturation magnetization (Ms), which can lead to more efficient magnetic targeting. In particular, the introduction of zinc and manganese into the crystalline structure of the magnetic particle generates some changes in the material properties, enhancing their potential use in theranostic applications. 
  • 591
  • 07 Dec 2021
Topic Review
Nymphaea hybrid
Nymphaea hybrid is a perennial aquatic herb of Nymphaea in Nymphaeaceae. It is fragrant, colourful and indispensable as the main plant in features of water purification. Here includes the extraction from Nymphaea hybrid, isolation, structural characterization and evaluation of antioxidant capacity in vitro. 
  • 591
  • 29 Mar 2022
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