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Topic Review
Therapeutic Potential of G-quadruplex Structural Junctions
We analyze further extension of G-quadruplexes by additional structural elements and investigate whether junction of G-quadruplex with duplex, hairpin, triplex or second G-quadruplex motif is favorable for aptamers stability and biological activity. Furthermore, we indicate the specific and pivotal role of G-quadruplex domain and the additional structural elements in the interactions with target molecules. Finally, we consider the potency of G-quadruplex junctions in the future applications and indicate the emerging research area that is still waiting for development to obtain highly specific and effective nucleic acid-based molecular tools.
  • 876
  • 15 Oct 2021
Topic Review
Isoquinolone
Isoquinolones (isoquinolin-1(2H)-ones): the atom- and step-economic syntheses.
  • 876
  • 14 Jul 2021
Topic Review
Additive Manufacturing of Ti-Based Alloys
TiAl-based intermetallic alloys have come to the fore as the preferred alloys for high-temperature applications. Conventional methods (casting, forging, sheet forming, extrusion, etc.) have been applied to produce TiAl intermetallic alloys. However, the inherent limitations of conventional methods do not permit the production of the TiAl alloys with intricate geometries. Additive manufacturing technologies such as electron beam melting (EBM) and laser powder bed fusion (LPBF), have been used to produce TiAl alloys with complex geometries. EBM technology can produce crack-free TiAl components but lacks geometrical accuracy. LPBF technology has great geometrical precision that could be used to produce TiAl alloys with tailored complex geometries, but cannot produce crack-free TiAl components. To satisfy the current industrial requirement of producingcrack-free TiAl alloys with tailored geometries, the paper proposes a new heating model for the LPBF manufacturing process. The model could maintain even temperature between the solidified and subsequent layers, reducing temperature gradients (residual stress), which could eliminate crack formation. The new conceptualized model also opens a window for in-situ heat treatment of the built samples to obtain the desired TiAl (gama-phase) and Ti3Al (α2-phase) intermetallic phases for high-temperature operations. In situ heat treatment would also improve the homogeneity of the microstructure of LPBF manufactured samples.
  • 876
  • 26 Aug 2021
Topic Review
Indomethacin Increases HSA-Quercetin Binding
Human serum albumin (HSA) is the most abundant carrier protein in the human body. Competition for the same binding site between different ligands can lead to an increased active concentration or a faster elimination of one or both ligands. Indomethacin and quercetin both bind to the binding site located in the IIA subdomain. To determine the nature of the HSA-indomethacin-quercetin interactions, spectrofluorometric, docking, molecular dynamics studies, and quantum chemical calculations were performed. The results show that the indomethacin and quercetin binding sites do not overlap. Moreover, the presence of quercetin does not influence the binding constant and position of indomethacin in the pocket. However, binding of quercetin is much more favorable in the presence of indomethacin, with its position and interactions with HSA significantly changed. These results provide a new insight into drug-drug interactions, which can be important in situations when displacement from HSA or other proteins is undesirable or even desirable. This principle could also be used to deliberately prolong or shorten the xenobiotics' half-life in the body, depending on the desired outcomes.
  • 875
  • 06 Nov 2020
Topic Review
Applications of Boron Nitride QDs
Boron nitride quantum dots (BNQDs) have gained increasing attention for their versatile fluorescent, optoelectronic, chemical, and biochemical properties. 
  • 875
  • 06 Apr 2021
Topic Review
Aromatic Polyimide Films for Electronic Applications
Aromatic polyimides have excellent thermal stability, mechanical strength and toughness, high electric insulating properties, low dielectric constants and dissipation factors, and high radiation and wear resistance, among other properties, and can be processed into a variety of materials, including films, fibers, carbon fiber composites, engineering plastics, foams, porous membranes, coatings, etc. Aromatic polyimide materials have found widespread use in a variety of high-tech domains, including electric insulating, microelectronics and optoelectronics, aerospace and aviation industries, and so on, due to their superior combination characteristics and variable processability. In recent years, there have been many publications on aromatic polyimide materials, including several books available to readers. In this review, the representative progress in aromatic polyimide films for electronic applications, especially in our laboratory, will be described.
  • 874
  • 05 Apr 2022
Topic Review
Graphene-Based Environmental Sensors
Graphene-Based Environmental Sensors means use graphene as a sensing platform for environmental applications. Especially, we highlight the electrical and optical sensing devices developed based on graphene and its derivatives.
  • 873
  • 04 May 2021
Topic Review
Tetravalence
In chemistry, the valence (US spelling) or valency (British spelling) of an element is the measure of its combining capacity with other atoms when it forms chemical compounds or molecules.
  • 872
  • 27 Oct 2022
Topic Review
Hydraulic Powered Soft Actuators
Soft actuators have received extensive attention in robotics and smart device applications due to their distinctive dexterity and compliance. Among them, hydraulic soft actuators play an important role in the area because they have much higher specific power and power density than other types such as pneumatic soft actuators. Nevertheless, the deformation of flexible materials in soft actuators brings about inherent hysteresis and nonlinearity, which severely hinders them from producing the desired movement in the presence of advanced control strategies. 
  • 872
  • 21 Dec 2022
Topic Review
Biosynthesis of Nanoparticles Using Plant Extracts
Plant extracts and essential oils have a wide variety of molecules with potential application in different fields such as medicine, the food industry, and cosmetics. Furthermore, these plant derivatives are widely interested in human and animal health, including potent antitumor, antifungal, anti-inflammatory, and bactericidal activity. Given this diversity, different methodologies were needed to optimize the extraction, purification, and characterization of each class of biomolecules. In addition, these plant products can still be used in the synthesis of nanomaterials to reduce the undesirable effects of conventional synthesis routes based on hazardous/toxic chemical reagents and associate the properties of nanomaterials with those present in extracts and essential oils. 
  • 872
  • 10 Apr 2023
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