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Topic Review
Recent Advances in A3 Coupling with Metal Salts
Recent advances in the metal salt catalysed multicomponent reaction of aldehydes, amines, and alkynes, known as A3 coupling, which yields propargylamines, a valuable organic scaffold.
  • 1.2K
  • 04 Jul 2022
Topic Review
Bucherer–Bergs Multicomponent Synthesis of Hydantoins
The Bucherer–Bergs reaction is one of the most convenient general methods for the preparation of 5-substituted and 5,5-disubstituted hydantoins (imidazolidine-2,4-diones, 2,4-dioxoimidazolidines). Generally, in this multicomponent reaction, the aldehyde or ketone in aqueous ethanol is heated at 60–70° with potassium (or sodium) cyanide and ammonium carbonate to produce directly hydantoins 1.
  • 1.2K
  • 28 Jul 2021
Topic Review
Computational Drug Design of TB
Developing new, more effective antibiotics against resistant Mycobacterium tuberculosis that inhibit its essential proteins is an appealing strategy for combating the global tuberculosis (TB) epidemic. Finding a compound that can target a particular cavity in a protein and interrupt its enzymatic activity is the crucial objective of drug design and discovery. Such a compound is then subjected to different tests, including clinical trials, to study its effectiveness against the pathogen in the host. In recent times, new techniques, which involve computational and analytical methods, enhanced the chances of drug development, as opposed to traditional drug design methods, which are laborious and time-consuming. The computational techniques in drug design have been improved with a new generation of software used to develop and optimize active compounds that can be used in future chemotherapeutic development to combat global tuberculosis resistance.
  • 1.2K
  • 17 Dec 2021
Topic Review
Protective Coatings for ATF Claddings
Since 2011, following the tragic Fukushima Daiichi Nuclear accident, great attention has been devoted to the development of a new concept of nuclear fuel to improve the safety of nuclear reactors during normal operation, transient modes and under accident conditions. A concept called “accident tolerant fuel (ATF)” indicates a strategy to prevent/limit the interaction of cladding material with water steam, or hydrogen embrittlement, and to reduce heat generation during cladding oxidation and increase “processing time” under accident conditions before re-flooding of the nuclear core.
  • 1.2K
  • 11 Oct 2022
Topic Review
Shugoshin
Shugoshin (meaning “guardian spirit” in Japanese) is a homo-dimeric phospho-protein belonging to the shugoshin protein family. Shugoshin is conserved from single-celled yeast to multicellular mammals including humans. Shugoshin shares several structural features with other members of the shugoshin family, including a basic region at the C-terminus that is essential for centromere binding, chromosome localization, and an N-terminal coiled-coil domain that may regulate its dimerization and interaction with other proteins.
  • 1.2K
  • 27 Jul 2021
Topic Review
CMS Membranes for Olefin/Paraffin Separation
Carbon molecular sieve (CMS) membranes have been developed to replace or support energy-intensive cryogenic distillation for olefin/paraffin separation. Olefin and paraffin have similar molecular properties, but can be separated effectively by a CMS membrane with a rigid, slit-like pore structure. A variety of polymer precursors can give rise to different outcomes in terms of the structure and performance of CMS membranes.
  • 1.2K
  • 26 Aug 2021
Topic Review
Carbon-Based Composites
Carbon-based composites are materials in which a primary component in the form of a carbon structure or structures (graphene, carbon nanotubes, mesoporous carbon, etc.) and usually an inorganic phase or phases are combined into one system. Such a material is expected to exhibit additive or synergetic interfacial effects resulting in enhanced properties, such as reactivity in catalytic or electrocatalytic reactions.
  • 1.2K
  • 14 Dec 2021
Topic Review
Benzil
Benzil (BZ) can be converted almost quantitatively to benzoyl peroxide (BP) in aerated polymer films upon irradiation at >400 nm (i.e., the long-wavelength edge of the n→π* absorption band of BZ, where BP does not absorb).
  • 1.2K
  • 20 Sep 2021
Topic Review
Nanoparticle–Graphene based Nanocomposites
Bacterial infections are a leading cause of death in both Europe and USA. The use of antibacterial nanomaterials is a very promising approach to combat the microorganisms due to their high specific surface area and intrinsic or chemically incorporated antibacterial action. Graphene, a two dimensional carbon nanomaterial with excellent mechanical, thermal, and electrical properties, and its derivatives, like graphene oxide (GO) and reduced graphene oxide (rGO), are very good candidates for controlling microbial infections. Nonetheless, the mechanisms of antimicrobial action, their cytotoxicity, and other issues continue imprecise. This review offers select examples on the leading advances in the development of antimicrobial nanocomposites incorporating inorganic nanoparticles and graphene or its derivatives, with the goal of providing a improved understanding of the antibacterial properties of graphene-based nanomaterials.
  • 1.2K
  • 02 Nov 2020
Topic Review
CNT-Based Chemical Sensors
Carbon nanotubes (CNTs) combine high electrical conductivity with high surface area and chemical stability, which makes them very promising for chemical sensing. 
  • 1.2K
  • 10 Feb 2022
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