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Topic Review
Research Status of Graphene Polyurethane Composite Coating
Graphene material has a variety of excellent properties and applications in energy storage, biomaterials, photoelectric devices, and other fields. With the progress of nanotechnology, graphene nanomaterials have shown their advantages in the field of new nano-corrosion coatings with their high barrier structure. In addition, polyurethane is also widely used in the field of anti-corrosion coatings due to its excellent chemical resistance, mechanical properties, and weathering resistance. The preparation of composite coatings by combining graphene nanomaterials with traditional polyurethane (PU) coatings has opened up a new way for the research and development of new anticorrotic coatings.
  • 702
  • 22 Feb 2022
Topic Review
Design and Preparation of Chitosan Hydrogels
Flexible wearable sensors show great potential for applications in wearable devices, remote health monitoring, artificial intelligence, soft robotics, and artificial skin due to their stretchability, bendability, thinness and portability, and excellent electrical properties. Chitosan (CS) is the only alkaline polysaccharide present in nature, which is deacetylated from chitin, and has attracted great interest in the biomedical field due to biocompatibility, non-toxicity, biodegradability, antimicrobial ability and safety. Tremendous efforts have focused on the advancement of chitosan-based hydrogels (CS-Gels) to realize multifunctional wearable sensing by modifying hydrogel networks with additives/nanofillers/functional groups.
  • 702
  • 17 Jan 2023
Topic Review
Obstruction and Advancement in Achieving SDG in Bangladesh
For a developing country such as Bangladesh, renewable energy is immensely important for its entire development and advancement. Bangladesh has taken steps to increase the development capacity in the renewable energy sector and to fulfill the target of achieving one hundred percent electrification. 
  • 702
  • 06 Apr 2023
Topic Review
Metal Phosphates and Pyrophosphates as Proton Conductors
It is about the progress in metal phosphate structural chemistry focused on proton conductivity properties. Attention is paid to structure–property relationships, which ultimately determine the potential use of metal phosphates and derivatives in devices relying on proton conduction. The origin of their conducting properties, including both intrinsic and extrinsic conductivity, is rationalized in terms of distinctive structural features and the presence of specific proton carriers or the factors involved in the formation of extended hydrogen-bond networks.
  • 702
  • 19 Apr 2022
Topic Review
PAMAM-calix-dendrimers
A convenient method for the synthesis of the first generation PAMAM dendrimers based on the thiacalix[4]arene has been developed for the first time. Three new PAMAM-calix-dendrimers with the macrocyclic core in cone, partial cone, and 1,3-alternate conformations were obtained with high yields.
  • 701
  • 11 Nov 2021
Topic Review
Biological Activity of Flavones, Flavonols, and Aurones
Flavonoids are a widely distributed group of natural polyphenolic compounds that are found in plants usually in glycosylated form and have been shown to possess a wide range of biological activities, including antioxidant, anti-inflammatory, antibacterial, antiviral, and anticancer properties, making them an attractive target for synthesis and further research.
  • 701
  • 12 Sep 2023
Topic Review
Nanomaterials as a Sustainable Choice for Treating Wastewater
The removal of dyes from textile effluents utilizing advanced wastewater treatment methods with high efficiency and low cost has received substantial attention due to the rise in pollutants in water. For the purpose of treating sewage, the special properties of nanoparticles are being carefully researched. The ability of nanomaterials to remove organic matter, fungus, and viruses from wastewater is another benefit. Nanomaterials are employed in advanced oxidation techniques to clean wastewater. Additionally, because of their small dimensions, nanoparticles have a wide effective area of contact. Due to this, nanoparticles’ adsorption and reactivity are powerful. The improvement of nanomaterial technology will be beneficial for the treatment of wastewater. 
  • 701
  • 14 Dec 2022
Topic Review
Colon Carcinomas
Colon carcinomas themselves comprise over two-thirds of all colorectal cancers with an overall 5-year survival rate of 64%, which rapidly decreases to 14% when the cancer becomes metastatic. Depending on the stage of colon carcinoma at diagnosis, patients can undergo surgery to attempt complete tumor resection or move directly to chemotherapy with one or a combination of drugs. As with most cancers, colon carcinomas do not always respond to chemotherapies, so targeted therapies and immunotherapies have been developed to aid chemotherapy. We report the development of a local combination therapy for colon carcinoma whereby chemo- and immuno-therapeutic entities are delivered intratumorally to maximize efficacy and minimize off-target side effects. A hydrophobic chemotherapeutic agent, docetaxel (DTX), and cholesterol-modified Toll-like receptor 9 (TLR9) agonist CpG (cho-CpG) oligonucleotide are co-loaded in synthetic HDL (sHDL) nanodiscs. In vivo survival analysis of MC-38 tumor-bearing mice treated intratumorally with DTX-sHDL/CpG (median survival; MS = 43 days) showed significant improvement in overall survival compared to mice treated with single agents, free DTX (MS = 23 days, p <0.0001) or DTX-sHDL (MS = 28 days, p<0.0001). Two of seven mice treated with DTX-sHDL/CpG experienced complete tumor regression. None of the mice experienced any systemic toxicity as indicated by body weight maintenance and normal serum enzyme and protein levels. In summary, we have demonstrated that chemo- and immuno-therapies can be co-loaded into sHDLs, delivered locally to the tumor, and can be used to improve survival outcomes significantly compared to chemotherapy alone.
  • 701
  • 29 Oct 2020
Topic Review
Cyclo- and Polyphosphazenes for Biomedical Applications
Cyclic and polyphosphazenes are extremely interesting and versatile substrates characterized by the presence of -P=N- repeating units. The chlorine atoms on the P atoms in the starting materials can be easily substituted with a variety of organic substituents, thus giving rise to a huge number of new materials for industrial applications. A wide variety of new phosphazene systems, either trimeric or polymeric, have been developed as biomaterials in view of different applications. The materials to apply in biomedical applications should be biocompatible.
  • 700
  • 09 Dec 2022
Topic Review
Supramolecular Combination Therapy Based on Metal Coordination Complexes
Supramolecular combination therapy adopts supramolecular materials to design intelligent drug delivery systems with different strategies for cancer treatments. Thereinto, macrocyclic supramolecular materials play a crucial role in encapsulating anticancer drugs to improve anticancer efficiency and decrease toxicity towards normal tissue by host–guest interaction. Biomacromolecule drugs have become one of the important medications for the therapeutics of human diseases. The choice of an adequate drug delivery method is essential to ensuring the therapeutic efficacy of biomacromolecule medications in vivo due to the high tendency of biomacromolecule pharmaceuticals to degrade in the human body.
  • 700
  • 18 Nov 2022
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