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Topic Review
Biography
Topic Review
Pollen on Adverse Respiratory Outcomes
Respiratory diseases such as asthma, allergic rhinitis (AR) and chronic obstructive pulmonary disease (COPD) affect millions worldwide and pose a significant global public health burden. Over the years, changes in land use and climate have increased pollen quantity, allergenicity and duration of the pollen season, thus increasing its impact on respiratory disease.
519
28 Jun 2022
Topic Review
Physical Exercise and Saliva Composition
Salivary glands are exocrine organs that produce a large amount of fluid. Through the saliva, electrolytes and other substances are transferred from the inner of the glands to the oral cavity. The mean volume of the fluid is estimated to be 750 mL/day, which almost represents 20% of the overall plasma volume. Apart from the major salivary glands (2–5 mL/min), saliva is also secreted by several minor glands at a rate of 0.5 mL/min.
519
28 Jan 2022
Topic Review
Metabolic Syndrome, Cognitive Impairment and Diet
Early MetS detection may be helpful to prevent or delay cognitive decline. Moreover, this study highlights the importance of healthy nutritional habits to reverse such conditions and the urgency of early lifestyle interventions.
518
18 Jan 2022
Topic Review
Ketogenic Diet and Resistance Training
Ketogenic diets (KDs) aim at inducing physiological ketosis (i.e., an increase in the concentration of ketone bodies in blood, usually above >0.5 mmol/L) through a marked reduction in carbohydrate intake (commonly <50 g/d or <10% of total energy intake). KDs have gained popularity in recent years among athletes. By virtue of the restriction they induce in carbohydrate availability, KDs promote the use of ketone bodies (i.e., acetoacetate, acetone and β-hydroxybutyrate (BHB)) as an alternative energy substrate for different body tissues. Owing to the low carbohydrate availability induced by this type of diet, KDs induce a metabolic switch towards a greater reliance on fatty acids, which are required for the production of ketone bodies.
518
08 Sep 2021
Topic Review
Rate Response in Implantable Cardiac Pacemakers
Modern cardiac pacemakers are equipped with a function that allows the heart rate to adapt to the current needs of the patient in situations of increased demand related to exercise and stress ("rate-response" function). Modern pacemakers are equipped with a number of functions and algorithms that adjust the basal rate of pacing to situations associated with increased demands of the body—this requires sensors for accelerometer-based measurements; measurements of minute ventilation; measurements of myocardial contractility; and the analysis of myocardial, transthoracic, and transvalvular impedances.
517
29 May 2023
Topic Review
Role of 10-Hydroxy-2-decenoic Acid in Alzheimer’s Disease
Alzheimer’s disease (AD) represents a significant public health concern in modern society. Metabolic syndrome (MetS), which includes diabetes mellitus (DM) and obesity, represents a modifiable risk factor for AD. MetS and AD are interconnected through various mechanisms, such as mitochondrial dysfunction, oxidative stress, insulin resistance (IR), vascular impairment, inflammation, and endoplasmic reticulum (ER) stress. Therefore, it is necessary to seek a multi-targeted and safer approach to intervention. Thus, 10-hydroxy-2-decenoic acid (10-HDA), a unique hydroxy fatty acid in royal jelly, has shown promising anti-neuroinflammatory, blood–brain barrier (BBB)-preserving, and neurogenesis-promoting properties.
521
01 Sep 2023
Topic Review
Mechanistic Approaches to Understanding Psychological Resilience to Suicide
Suicidal experiences include suicidal thoughts, tendencies, urges, compulsions, plans, behaviours, attempts and death. Such experiences are a global concern with substantial suicide prevention measures being developed and implemented worldwide. People need to try to understand how resilience to suicidal experiences in those who have severe mental health problems, including psychosis, fluctuates within and between individuals using a multi-componential approach. This understanding rests on identifying the psychological mechanisms which underpin resilience to suicidal experiences whilst also interacting with resilience to psychosis. There are four models of resilience, namely, the unidimensional model, the two dimensional buffering model, the recovery model and the maintenance model.
517
17 Jun 2022
Topic Review
Mediterranean Diet and Cognitive Functions
Mediterranean Diet (MedDiet) consists of a large number of vegetables, fruits, beans, legumes, whole grains, olive oil, seeds, herbs and spices, as well as fish, seafood, eggs, cheese and poultry and disrecommends unusual red meats and sweets. In particular, a high intake of fish and low intake of alcohol contributes to the delay of cognitive decline.
517
08 Jul 2021
Topic Review
Histoplasmosis in Children
Histoplasmosis is a systemic fungal infection caused by a dimorphic fungi and occurring globally. It is endemic in the Ohio and Mississippi river valleys of the United States of America, India and Southeast Asia. The clinical presentation of histoplasmosis mimics features seen in tuberculosis (TB) and may be misdiagnosed as such.
517
12 Jul 2021
Topic Review
Anti-CCR5 Therapy, Breast Cancer and Its Microenvironment
Breast cancer represents the most common malignancy among women in the world. The local microenvironment around the tumor plays a great role in cancer progression and invasion, representing a promising therapeutic target. CCL5 is a potent chemokine with a physiological role of immune cell attraction and has gained particular attention in R&D for breast cancer treatment. Its receptor, CCR5, is a well-known co-factor for HIV entry through the cell membrane and CCR5 blocking represents a mainstay of HIV treatment. Interestingly, CCL5 is currently described as key pro-oncogenic factor, especially in breast cancer. Several studies blocking the CCL5/CCR5 axis show cancer cells become less invasive and less malignant, with less oncogenic extracellular matrices.
516
28 Nov 2022
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