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Topic Review
Food of Pre-Hispanic Inhabitants from the Quito Plateau
In all of the different historical periods during its development, the pre-Hispanic inhabitants of the Quito plateau and its valleys used the flora and fauna for food and the development of their society. 
  • 467
  • 06 Dec 2022
Topic Review
PD-L1 in Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with a five-year survival rate of approximately 5–10%. The immune checkpoint blockade represented by PD-1/PD-L1 inhibitors has been effective in a variety of solid tumors. 
  • 444
  • 06 Dec 2022
Topic Review
Climatic and Environmental Factors in Disease Modeling
Climatic and environmental factors may influence the arbovirus disease outbreak, transmission, and surveillance. Thus, there is a call for further research on the area. To benefit from arbovirus modeling, it is crucial to consider the influence of climatic and environmental factors, especially in Africa, where there are limited studies exploring this phenomenon.
  • 528
  • 06 Dec 2022
Topic Review
Sanitation Workers in African cities
Sanitation workers provide an essential public service that is key to achieving the Sustainable Development Goals (SDG), but often costs them their dignity and health. Many governments in low- and middle-income countries fail to support their sanitation workforce. This is due, in part, to a lack of knowledge about sanitation workers’ needs and the challenges they face. 
  • 518
  • 06 Dec 2022
Topic Review
Early Forecasts of the COVID-19 Pandemic
This entry reviews early forecasting of the COVID pandemic in the context of forecast accuracy and epidemic and pandemic forecasting. 
  • 383
  • 05 Dec 2022
Topic Review
Dietary Sugars and Diabetes Development from Mitochondrial Perspective
Type 2 diabetes (T2D) has increased worldwide at an alarming rate. Metabolic syndrome (MetS) is a major risk factor for T2D development. One of the main reasons for the abrupt rise in MetS incidence, besides a sedentary lifestyle, is the westernized diet consumption, with high content of industrialized foods, rich in added dietary sugars (DS), mainly sucrose and fructose. It has been suggested that a higher intake of DS could impair metabolic function, inducing MetS, and predisposing to T2D. However, it remains poorly explored how excessive DS intake modulates mitochondrial function, a key player in metabolism. 
  • 551
  • 05 Dec 2022
Topic Review
The Potential of Exerkines in Women’s COVID-19
Exerkines are a group of promising molecules that may underlie the beneficial effects of physical exercise in diseases. The idea of exerkines is to understand the effects of physical exercise on diseases better. Exerkines have a high potential for the treatment of diseases and, considering that, there is still no study of the importance of exerkines on the most dangerous disease in the world in recent years, COVID-19.
  • 442
  • 05 Dec 2022
Topic Review
Pacific Open Learning Health Net
Pacific Open Learning Health Net (POLHN /ˈpɒlhən/) is a non-profit established in 2003, focused on distance education for health professionals working in the Pacific. Since 2004, it has provided free online courses for continuing professional development in a wide range of health and science related disciplines. These include self-directed, blended learning, instructor-led and hybrid courses. The platform runs on a free and open-source software learning management system. POLHN works with several universities institutions and Ministries of Health to develop online health related courses guided by WHO publications and accepted standard operating procedure. Since 2013, the platform has resembled a typical massive open online course (MOOC) platform.
  • 475
  • 02 Dec 2022
Topic Review
Intergenerationality Programs For Portuguese Population
The aging process is characterized by diverse and complex changes in the individual’s various dimensions, requiring continuous adaptation. In this sense, this transition can be faced from an active aging standpoint through strategies such as intergenerationality programs/projects, resulting in an active social participation and valorization that is so important to life in society. Portugal has undergone demographic changes, significantly transforming its age structure and populational dimension. In 2021, the aging index was 182.1%.
  • 618
  • 02 Dec 2022
Topic Review
COVID-19 Impact on Yellow/Lassa Fever Infections in Nigeria
Lassa fever (LF) and yellow fever (YF) belong to a group of viral hemorrhagic fevers (VHFs). These viruses have common features and damages the organs and blood vessels; they also impair the body’s homeostasis. Some VHFs cause mild disease, while some cause severe disease and death such as in the case of Ebola or Marburg. LF virus and YF virus are two of the emerging viruses in Africa, resulting in severe hemorrhagic fever in humans. Lassa fever virus is continuously on the rise both in Nigeria and neighboring countries in West Africa, with an estimate of over 500,000 cases of LF, and 5000 deaths, annually. YF virus is endemic in temperate climate regions of Africa, Central America (Guatemala, Honduras, Nicaragua, El Salvador), and South America (such as Brazil, Argentina, Peru, and Chile) with an annual estimated cases of 200,000 and 30,000 deaths globally. 
  • 593
  • 02 Dec 2022
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