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Topic Review
Genetic Testing for Early-Stage Breast Cancer
Early-stage breast cancer refers to breast cancer at clinical stage I–stage II, accounting for 73.1% of breast cancer. For patients at an early stage, rational and effective treatment is vital to improve prognosis. An increasing number of studies have made important progress, such as the OlympiA trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and the KARISMA trial of CYP2D6 mutations in patients using tamoxifen. Regimens of adjuvant and neoadjuvant treatments used to be mainly based on the clinicopathological characteristics of patients, but deficiencies are still noticed in forecasting the efficacy and prognosis. To complement the deficiency, MGAs, including Oncotype Dx, MammaPrint, RecurIndex, BCI, EndoPredict, and PAM50, were developed.
  • 181
  • 11 Dec 2023
Topic Review
Milk-Derived Antiviral Peptides Targeting Zoonotic Viruses
Animals often serve as reservoirs for viral zoonoses, diseases transmissible from animals to humans. While zoonotic viral diseases have been present in human populations since the inception of agricultural practices, they have gained increasing prominence as a global public health concern, particularly with recent epidemics like SARS-CoV-2 (COVID-19). Some of these diseases are categorized as “emerging infectious diseases” due to their newfound recognition or significant changes in their range and epidemiology. Notable zoonotic diseases include influenza, Ebola virus, West Nile virus, emerging coronaviruses, monkeypox, rabies, Zika, and Lyme disease. Six out of every ten infectious diseases in humans are zoonotic, with many being viral. Therefore, it is imperative to enhance our capabilities to prevent and respond to these diseases, adopting a One Health approach. Finding new therapies and ways to prevent viral zoonoses is just as important as increasing efforts on surveillance and early detection, and with the rising amount of research demonstrating the potential of bioactive peptides produced from milk as antivirals, a vital opportunity arises to assess their usage in viral diseases with a focus on One Health. Indeed, several peptides derived from milk protein parents have shown potential for zoonotic viral diseases. 
  • 181
  • 20 Feb 2024
Topic Review
Full Value of Vaccine Assessment
A framework to guide the assessment and communication of the value of a vaccine—the Full Value of Vaccine Assessment (FVVA)—has been developed by the WHO. The FVVA framework offers a holistic assessment of the value of vaccines, providing a synthesis of evidence to inform the public health need of a vaccine, describing the supply and demand aspects, its market and its impact from a health, financial and economic perspective. 
  • 179
  • 08 Mar 2024
Topic Review
Nature-Based Interventions for Adults with Developmental Disabilities
Autistic adults often face higher levels of depression, anxiety, and stress and reduced levels of quality of life and employment in comparison to their neurotypical peers. Nature-based interventions (NBIs), which utilize outdoor environments and activities for health and wellbeing outcomes, could provide possibilities to meet these various needs.
  • 179
  • 18 Feb 2024
Topic Review
Management of Lung Toxicity with T-DXd in Canada
Ongoing advances in precision cancer therapy have increased the number of molecularly targeted and immuno-oncology agents for a variety of cancers, many of which have been associated with a risk of pulmonary complications, among the most concerning being drug-induced interstitial lung disease/pneumonitis (DI-ILD). As the number of patients undergoing treatment with novel anticancer agents continues to grow, DI-ILD is expected to become an increasingly significant clinical challenge. Trastuzumab deruxtecan (T-DXd) is an antibody–drug conjugate targeting human epidermal growth factor receptor 2 that is gaining widespread use in the metastatic breast cancer setting and is undergoing exploration for other oncologic indications. ILD/pneumonitis is an adverse event of special interest associated with T-DXd, which has potentially fatal consequences if left untreated and allowed to progress. When identified in the asymptomatic stage (grade 1), T-DXd-related ILD can be monitored and treated effectively with the possibility of treatment continuation. Delayed diagnosis and/or treatment, however, results in progression to grade 2 or higher toxicity and necessitates immediate and permanent discontinuation of this active agent. Strategies are, therefore, needed to optimize careful monitoring during treatment to ensure patient safety and optimize outcomes.
  • 178
  • 19 Sep 2023
Topic Review
Role of Non-Coding RNAs in Tumor Microenvironment
Non-coding RNAs (ncRNAs) are a group of molecules critical for cell development and growth regulation. Cancer creates and expands the Tumor Microenvironment, which in turn supports cancer progression.
  • 176
  • 11 Sep 2023
Topic Review
Motherhood and Schizophrenia
Being a good parent is a very difficult task, made more difficult in the context of serious psychiatric illness such as schizophrenia. The symptoms of the disorder are aggravated by the associated stigma, by poverty, social isolation, and adverse life circumstances. Mothers with schizophrenia need to make difficult decisions, which are hampered by lack of information, social isolation, and no resources. Assistance is theoretically available but is not always accessible, and may not prove effective. Care providers to this population are recommended to partner with mothers with schizophrenia, appreciate their strengths as well as their frailties, offer a wide array of family services and social supports, monitor closely, and be generous with positive feedback.
  • 174
  • 30 Jan 2024
Topic Review
Promoting Better Mental Health in People with Autism
The rising prevalence of autism internationally has been accompanied by an increased appreciation of the poorer mental health experienced by people with this condition and also of their family care-givers. In particular, higher incidences of anxiety and depression are reported in high-income nations and these conditions are likely to be under-recognised and under-reported in lower-resourced regions or countries. Mainstream mental health services seem to be ill-equipped to respond adequately to the needs of autistic persons and their care-givers.
  • 173
  • 07 Feb 2024
Topic Review
Revolutionizing HIV-1 Viral Load Monitoring in India
India continues to grapple with a significant burden of HIV infections. Despite notable progress in prevention and treatment efforts, multiple challenges, such as high-risk populations, inadequate testing facilities, and limited access to healthcare in remote areas, persist. Though the Government of India offers HIV-1 plasma viral load testing at various medical centers, aiding treatment decisions and monitoring antiretroviral therapy effectiveness, enhancing care for individuals living with HIV under the National AIDS Control Program (NACP), the nation’s large population and diverse demographics further complicate its outreach and response. Hence, strategic interventions and alternative methods of testing remain crucial to curbing HIV transmission and improving the quality of life for those affected. Dried blood spot (DBS) sampling has emerged as a convenient and cost-effective alternative for HIV-1 viral load testing, revolutionizing the landscape of diagnostic and monitoring strategies for HIV infection. Though the plasma-based viral load remains the gold standard for monitoring HIV-1, DBS-based HIV-1 viral load testing holds immense promise for improving access to care, particularly in resource-limited settings where traditional plasma-based methods may be logistically challenging. DBS entails the collection of a small volume of blood onto filter paper, followed by drying and storage. This approach offers numerous advantages, including simplified sample collection, transportation, and storage, reducing the need for cold-chain logistics. 
  • 173
  • 18 Feb 2024
Topic Review
Use of Biosensors and IoMT in COVID-19 Prediction
By using a connected network, a healthcare system with the Internet of Things (IoT) functionality can effectively monitor COVID-19 cases. IoT helps a COVID-19 patient recognize symptoms and receive better therapy more quickly. A critical component in measuring, evaluating, and diagnosing the risk of infection is artificial intelligence (AI). It can be used to anticipate cases and forecast the alternate incidences number, retrieved instances, and injuries. In the context of COVID-19, IoT technologies are employed in specific patient monitoring and diagnosing processes to reduce COVID-19 exposure to others.
  • 173
  • 29 Nov 2023
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