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All Topic Review Biography
Topic Review
Treatment of Halitosis
Halitosis, or bad breath, is an oral health problem characterized by an unpleasant malodor emanating from the oral cavity. This condition can have different origins and causes a negative burden in social interactions, communication and quality of life, and can in uncommon cases be indicative of underlying non-oral non-communicable diseases.
  • 349
  • 21 Sep 2022
Topic Review
Rapid Methods for Early Detection of SARS-CoV-2 Variants
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) straightaway showed its tendency to mutate and adapt to the host, culminating in the emergence of variants; so it immediately became of crucial importance to be able to detect them quickly but also to be able to monitor in depth the changes on the whole genome to early identify the new possibly emerging variants.
  • 349
  • 29 Sep 2022
Topic Review
Application for Food Plan Management Alzheimer Patients
Alzheimer’s disease is a type of dementia that affects many individuals, mainly in an older age group. Over time, it leads to other diseases that affect their autonomy and independence. The quality of food ingestion is a way to mitigate the disease and preserve the patient’s well-being, which substantially impacts their health.
  • 349
  • 15 May 2023
Topic Review
Personalization of Therapy in High-Grade Serous Tubo-Ovarian Cancer
High-grade serous tubo-ovarian cancer (HGSTOC) is the most lethal tumor of the female genital tract. The foregoing therapy consists of cytoreduction followed by standard platinum/taxane chemotherapy; alternatively, for primary unresectable tumors, neo-adjuvant platinum/taxane chemotherapy followed by delayed interval cytoreduction. In patients with suboptimal surgery or advanced disease, different forms of targeted therapy have been accepted or tested in clinical trials. Studies on HGSTOC discovered its genetic and proteomic heterogeneity, epigenetic regulation, and the role of the tumor microenvironment. These findings turned attention to the fact that there are several distinct primary tumor subtypes of HGSTOC and the unique biology of primary, metastatic, and recurrent tumors may result in a differential drug response. This results in both chemo-refractoriness of some primary tumors and, what is significantly more frequent and destructive, secondary chemo-resistance of metastatic and recurrent HGSTOC tumors. Treatment possibilities for platinum-resistant disease include several chemotherapeutics with moderate activity and different targeted drugs with difficult tolerable effects. Therefore, the question appears as to why different subtypes of ovarian cancer are predominantly treated based on the same therapeutic schemes and not in an individualized way, adjusted to the biology of a specific tumor subtype and temporal moment of the disease.
  • 349
  • 05 Jan 2024
Topic Review
Health in Chile’s Constitutional Process
Chile is a high-income country in Latin America that faces great socioeconomic inequality and a segmented–public and private–health system. In response to the serious political crisis which took place in 2019, Chile’s political parties came together to deliberate on an institutional solution, attending to the social demands of fairness around several issues, such as pensions, health, and education. The result was the elaboration of the “Agreement for Social Peace and the New Constitution’’. In the process towards elaborating a draft for a new constitution, different mechanisms of civil participation were enabled, including the Popular Initiatives for Norms, an online website where individuals or collectives could submit proposals to be considered.
  • 348
  • 03 Jan 2023
Topic Review
Wearables for Monitoring and Postural Feedback
Wearables offer a promising solution for simultaneous posture monitoring and/or corrective feedback. Some wearables have the feature to provide real-time corrective sensory feedback when adopting inadequate postures. This feedback can be auditory (typically conveyed through diverse auditory channels), visual (usually displayed by screens or projectors), haptic (application of vibratory stimulus), or a combination of these, providing information based on performance or outcome.
  • 347
  • 29 Feb 2024
Topic Review
Reminiscence Therapy
Reminiscence therapy (RT) consists of thinking about one’s own experiences through the presentation of memory-facilitating stimuli, and it has as its fundamental axis the activation of emotions. An innovative way of offering RT involves the use of technology-assisted applications, which must also satisfy the needs of the user.
  • 348
  • 20 May 2022
Topic Review
Human-Centric Approach in Healthcare 4.0
The cyberspace depicts an increasing number of difficulties related to security, especially in healthcare. This is evident from how vulnerable critical infrastructures are to cyberattacks and are unprotected against cybercrime. Users, ideally, should maintain a good level of cyber hygiene, via regular software updates and the development of unique passwords, as an effective way to become resilient to cyberattacks. Cyber security breaches are a top priority, and most users are aware that their behaviours may put them at risk; however, they are not educated to follow best practices, such as protecting their passwords. Mass cyber education may serve as a means to offset poor cyber security behaviours; however, mandatory education becomes a questionable point if the content is not focused on human factors, using human-centric approaches and taking into account end users’ behaviours, which is currently the case. Papers report the best practices that should be used by healthcare organisations and healthcare professionals to maintain good cyber hygiene and how these can be applied via a healthcare use case scenario to increase awareness related to data privacy and cybersecurity. This is an issue of great importance and urgency considering the rapid increase of cyberattacks in healthcare organisations, mainly due to human errors. Further to that, based on human-centric approaches, the long-term vision and future work involves facilitating the development of efficient practices and education associated with cybersecurity hygiene via a flexible, adaptable and practical framework.
  • 348
  • 17 Mar 2023
Topic Review
World-Renowned “Swiss” Pediatricians
The early and correct recognition of rare pediatric diseases is essential for decisions related to treatment options, the monitoring of treatment results, and the prevention of complications, as well as the estimation of prognosis and the counselling of patients, parents, and caregivers, including a risk estimation for recurrence in future pregnancies.
  • 348
  • 04 Dec 2023
Topic Review
Bempedoic Acid and Statins in Lipid-Lowering Strategy
Pharmacological research has led to the development of a new drug, the bempedoic acid, which further enrich the available therapies. This drug also acts on the biosynthesis of cholesterol but at upstream level than statins. From the biochemical point of view, it has the potential to be considered before the statin with consequent titration of statins to achieve the desirable LDL-C target. 
  • 348
  • 06 May 2023
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