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Topic Review
Neuro-Immune Modulation in Functional Somatic Syndromes
Functional somatic syndromes (FSS) are increasingly diagnosed in chronically ill patients presenting with an array of symptoms not attributed to physical ailments. Conditions such as chronic fatigue syndrome, fibromyalgia syndrome, or irritable bowel syndrome are common disorders that belong in this broad category. Such syndromes are characterised by the presence of one or multiple chronic symptoms including widespread musculoskeletal pain, fatigue, sleep disorders, and abdominal pain, amongst other issues. Symptoms are believed to relate to a complex interaction of biological and psychosocial factors, where a definite aetiology has not been established. Theories suggest causative pathways between the immune and nervous systems of affected individuals with several risk factors identified in patients presenting with one or more functional syndromes. Risk factors including stress and childhood trauma are now recognised as important contributors to chronic pain conditions. Emotional, physical, and sexual abuse during childhood is considered a severe stressor having a high prevalence in functional somatic syndrome suffers. Such trauma permanently alters the biological stress response of the suffers leading to neuroexcitatory and other nerve issues associated with chronic pain in adults. Traumatic and chronic stress results in epigenetic changes in stress response genes, which ultimately leads to dysregulation of the hypothalamic-pituitary axis, the autonomic nervous system, and the immune system manifesting in a broad array of symptoms. Importantly, these systems are known to be dysregulated in patients suffering from functional somatic syndrome. Functional somatic syndromes are also highly prevalent co-morbidities of psychiatric conditions, mood disorders, and anxiety.
  • 392
  • 23 Aug 2022
Topic Review
VitD3 and Autoimmune Thyroiditis
Active 1,25(OH)2 D3 is generated in immune cells via 1-α-hydroxylase, subsequently interacting with the VitD3 receptor to promote transcriptional and epigenomic responses in the same or adjacent cells. Despite considerable progress in deciphering the role of VitD3 in autoimmunity, its exact pathogenetic involvement remains to be elucidated. 
  • 391
  • 09 Dec 2022
Topic Review
Safety Management in Industry 5.0 Manufacturing
Safety management is a priority to guarantee human-centered manufacturing processes in the context of Industry 5.0, which aims to realize a safe human–machine environment based on knowledge-driven approaches. The traditional approaches for safety management in the industrial environment include staff training, regular inspections, warning signs, etc. Despite the fact that proactive measures and procedures have exceptional importance in the prevention of safety hazards, human–machine–environment coupling requires more sophisticated approaches able to provide automated, reliable, real-time, cost-effective, and adaptive hazard identification in complex manufacturing processes.
  • 391
  • 07 Mar 2024
Topic Review
Challenges for Artificial Intelligence in Recognizing Mental Disorders
Artificial Intelligence (AI) appears to be making important advances in the prediction and diagnosis of mental disorders. Researchers have used visual, acoustic, verbal, and physiological features to train models to predict or aid in the diagnosis, with some success. However, such systems are rarely applied in clinical practice, mainly because of the many challenges that currently exist. 
  • 391
  • 30 Dec 2022
Topic Review
An Underutilized Food “Miwu”
Miwu (“蘼芜” in Chinese), the stems and leaves of Ligusticum chuanxiong Hort. has been used in China as a food for least 800 years. Modern research has shown that Miwu has a high dietary fibre content, is rich in iron and low in sodium, and has a similar aroma to celery but more than 4 times the dietary fibre content. At the same time, the wide cultivation of this herb, in combination with the use of the root as medicine, can better enhance the utilisation of this plant.
  • 391
  • 29 Dec 2023
Topic Review
European Wild Carnivores and Antibiotic Resistant Bacteria
Antibiotic resistance is a global concern that affects not only human health but also the health of wildlife and the environment. Wildlife can serve as reservoirs for antibiotic-resistant bacteria, and antibiotics in veterinary medicine and agriculture can contribute to the development of resistance in these populations.
  • 390
  • 22 Dec 2023
Topic Review
COVID-19 Pandemic on Employee Sleep Quality
COVID-19 was declared a pandemic on 11 March 2020, following a rapid, exponential increase in global cases. The COVID-19 pandemic was associated with depression, anxiety, sleep disturbances, distress, and suicidal ideations. This study explored the association of the COVID-19 pandemic and employee sleep quality at a healthcare technology and services organization.
  • 390
  • 07 Feb 2022
Topic Review
Psychological and Cognitive Effects of Long COVID
Long COVID is a clinical syndrome characterized by profound fatigue, neurocognitive difficulties, muscle pain, weakness, and depression, lasting beyond the 3–12 weeks following infection with SARS-CoV-2.
  • 390
  • 11 Nov 2022
Topic Review
Sustainable Diets
A calorie-balanced diet mainly based on food of plant origin that would allow the attainment of 60% of daily caloric requirements and a low protein intake from animal foods (focusing in fish and poultry) could significantly reduce global morbi-mortality and the dietary environmental impact maintaining a framework of sustainability conditioned by the consumption of fresh, seasonal, locally produced and minimally packaged products. The implementation of sustainable diets requires working on the triangulation of concepts of food–health–environment from schools and that is permanently reinforced during all stages of the life by healthcare workers, who should establish the appropriate modifications according to the age, gender and health situation. 
  • 389
  • 23 Mar 2022
Topic Review
Occupational Exposure to Halogenated Anaesthetic Gases in Hospitals
Objective During the induction of gaseous anaesthesia, waste anaesthetic gases (WAGs) can be released into workplace air. Occupational exposure to high levels of halogenated WAGs may lead to adverse health effects; hence, it is important to measure WAGs concentration levels to perform risk assessment and for health protection purposes.
  • 388
  • 13 Mar 2023
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