Topic Review
Azadirachta indica (Neem) as a Potential Natural Active
Azadirachta indica (Neem) is a large tree that is native to India and is traditionally used due to its several properties, mainly to treat skin diseases, as well as its “herbicidal” activity. Its bark, leaves, seeds, fruits and flowers are widely used in medicinal treatment due to the presence of active secondary metabolites with biological effects, mainly limonoids and tetranortriterpenoids, such as azadirachtin. Thus, A. indica was studied in a variety of conditions, such as anticancer, antiseptic, anti-inflammatory and chemopreventive agents, as well as a biopesticide. 
  • 793
  • 09 Jun 2022
Topic Review
BHLHE41/DEC2 in Non-Small Lung Cancer Development
The circadian rhythm-related genes BHLHE40/DEC1 and BHLHE41/DEC2 have various functions under different cell and tissue conditions. BHLHE41/DEC2 has been reported to be both a cancer-suppressive and an oncogenic gene during cancer development. The effects of BHLHE41/DEC2 on differentiation have been examined using Bhlhe41/Dec2 knockout mice and/or in vitro differentiation models, and research has been conducted using genetic analysis of tumor cells, in vitro analysis of cancer cell lines, and immunohistochemical studies of the clinical samples.
  • 343
  • 08 Aug 2023
Topic Review
People at risk of suicide tend to be isolated and cannot share their thoughts. For this reason, suicidal ideation monitoring becomes a hard task. Therefore, people at risk of suicide need to be monitored in a manner capable of identifying if and when they have a suicidal ideation, enabling professionals to perform timely interventions. This entry aimed to develop the Boamente tool, a solution that collects textual data from users’ smartphones and identifies the existence of suicidal ideation.
  • 505
  • 15 Apr 2022
Topic Review
Brucella melitensis Vaccines
Brucella melitensis is recognized as one of the predominant zoonotic pathogens globally. Live-attenuated vaccine Rev 1 is currently the most effective vaccine for controlling B. melitensis in small ruminants. While Brucella inactivated, nanoparticle, and subunit vaccines are less effective and require multiple doses, live-attenuated vaccines are less expensive and more efficacious. Several drawbacks are associated with the administration of current attenuated B. melitensis vaccines, including interference with serological diagnostic tests, inducing abortion in pregnant animals, shedding in milk, and zoonotic infections in humans. 
  • 312
  • 06 Dec 2023
Topic Review
Lhia as A Chatbot for Breastfeeding Education
Human milk is the most important way to feed and protect newborns as it has the components to ensure human health. Human Milk Banks (HMBs) form a network that offers essential services to ensure that newborns and mothers can take advantage of the benefits of human milk.
  • 565
  • 16 Jun 2023
Topic Review
Lycium barbarum Deep-Processing Products of Fermentation
Lycium barbarum, a homology of medicine and food, contains many active ingredients including polysaccharides, polyphenol, betaine, and carotenoids, which has health benefits and economic value. The bioactive components in Lycium barbarum exhibit the effects of antioxidation, immune regulation, hypoglycemic effects, and vision improvement.
  • 281
  • 04 Mar 2024
Topic Review
Moringa oleifera Supplementation in Pregnancy and Breastfeeding
The Moringa tree is highly prized for its nutritional and medicinal properties. Almost all parts of the tree are used for industrial, medicinal and nutritional purposes.
  • 747
  • 25 Jun 2023
Topic Review
Salmonella and Salmonellosis in Public Health Implications
Salmonella is one of the most important zoonotic pathogen agents, causing an estimated 93.8 million cases of gastroenteritis worldwide annually, with 155,000 deaths. Efforts to reduce transmission of Salmonella by food and other routes must be implemented on a global scale. Salmonellosis control strategies are based on two fundamental aspects: (a) the reduction of prevalence levels in animals and (b) protection against infection in humans. 
  • 339
  • 23 Feb 2024
Topic Review
Vaccinium uliginosum and Vaccinium myrtillus
Vaccinium uliginosum L. (commonly known as bog bilberry) and Vaccinium myrtillus L. (commonly known as bilberry) are species of the genus Vaccinium (family Ericaceae). The red–purple–blue coloration of blueberries is attributed largely to the anthocyanins found in bilberries. Anthocyanins, known for their potent biological activity as antioxidants, have a significant involvement in the prophylaxis of cancer or other diseases, including those of metabolic origin.
  • 518
  • 06 Dec 2023
Topic Review
2LARTH® Micro-Immunotherapy Treatment
Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are two cytokines involved in the perpetuation of the chronic inflammation state characterizing rheumatoid arthritis (RA). Significant advances in the treatment of this pathology have been made over the past ten years, partially through the development of anti-TNF and anti-IL-1 therapies. However, major side effects still persist and new alternative therapies should be considered.
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  • 19 Nov 2021
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