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Topic Review
Circulating Tumor Cells in Colorectal Cancer
Circulating tumor cells (CTCs)  are intact cells separated from the primary tumor or metastases and released into the peripheral circulation. They were observed and discovered for the first time in 1869 in the blood of a patient with breast cancer. CTCs mainly originate from solid tumors of epithelial origin (breast, prostate, colon, and lung). CTCs are nucleated and express epithelial cell adhesion molecules (EpCAM) and/or cytokeratins (CK) in the cytoplasm without coexpressing the common leukocyte antigen CD45. It is known today that there is significant heterogeneity in cell species and surface markers, which represents a challenge in isolating all clinically relevant subpopulations of CTCs.
  • 477
  • 22 Nov 2022
Topic Review
Electrochemical Biosensors for Genetically Modified Crops Detection
Food safety issues are directly related to people's quality of life, so there is a need to develop efficient and reliable food contaminants’ detection devices to ensure the safety and quality of food. Electrochemical biosensors have the significant advantages of miniaturization, low cost, high sensitivity, high selectivity, rapid detection, and low detection limits using small amounts of samples, which are expected to enable on-site analysis of food products.
  • 551
  • 21 Nov 2022
Topic Review
Stress of Moving Homes
Moving homes has long been considered stressful, but how stressful is it? Researches try to utilise a micro-level individual dataset in the New Zealand Government’s Integrated Data Infrastructure (IDI) to reconstruct the Social Readjustment Rating Scale (SRRS) and thereby measure stress at a whole-of-population level. The effects of residential mobility on people’s mental well-being in the context of their stress-of-moving homes are examined.
  • 336
  • 21 Nov 2022
Topic Review
Research Trends of Physical Activity during Pregnancy
Physical activity (PA) during pregnancy has been proven beneficial to pregnant women, with a significant effect on ameliorating many severe gestational complications. Improvement of sedentary behaviour, lifestyle intervention through leisure-time PA, and preterm care are major research frontiers and have received extensive attention. 
  • 276
  • 21 Nov 2022
Topic Review
Monkeypox Epidemiology
Monkeypox virus (MPXV) belongs to the Poxviridae species. In the Poxviridae family, the Orthopoxvirus gene contains two enclosed strands of virus DNA (replicating in the cytoplasm and not the nucleus) and is called the monkeypox virus (MPXV).
  • 333
  • 18 Nov 2022
Topic Review
oXiris Hemofilter
Critically ill patients with sepsis and severe COVID-19 are commonly characterized by a dysregulated immune response and an acute kidney injury. Continuous renal replacement therapy (CRRT) is proposed as a promising adjuvant therapy to treat these critically ill patients by removing cytokines, pathogen-associated molecular patterns, and damage-associated molecular patterns from the blood. Although multiple hemofilters, including high-cutoff membranes, the oXiris hemofilter, the CytoSorb hemoadsorption device, and the Toraymyxin hemoperfusion cartridge, have been used in clinical practice, the use of the oXiris hemofilter in critically ill patients is of particular interest because it is the only kind of hemofilter that can provide renal replacement therapy, remove endotoxins, and adsorb cytokines simultaneously. 
  • 578
  • 18 Nov 2022
Topic Review
Antiviral Potential of Plants against COVID-19 during Outbreaks
COVID-19 has become a pandemic in most parts of the world. Although vaccines are available to fight the infection, their safety and clinical trial data are still questionable. Social distancing, isolation, the use of sanitizer, and personal productive strategies have been implemented to prevent the spread of the virus. Moreover, the search for a potential therapeutic molecule is ongoing. Based on experiences with outbreaks of SARS and MERS, many research studies reveal the potential of medicinal herbs/plants or chemical compounds extracted from them to counteract the effects of these viral diseases.
  • 544
  • 17 Nov 2022
Topic Review
Immunological Interactions between Intestinal Helminth Infections and Tuberculosis
Helminth infections are among the neglected tropical diseases affecting billions of people globally, predominantly in developing countries. Helminths’ effects are augmented by coincident tuberculosis disease, which infects a third of the world’s population. The role of helminth infections on the pathogenesis and pathology of active tuberculosis (T.B.) remains controversial. Parasite-induced suppression of the efficacy of Bacille Calmette-Guerin (BCG) has been widely reported in helminth-endemic areas worldwide. T.B. immune response is predominantly proinflammatory T-helper type 1 (Th1)-dependent. On the other hand, helminth infections induce an opposing anti-inflammatory Th2 and Th3 immune-regulatory response. 
  • 329
  • 17 Nov 2022
Topic Review
Intermittent Fasting on Metabolic Syndrome and Periodontal Disease
Metabolic syndrome (MetS) prevalence continues to climb significantly worldwide in today’s ad libitum society. MetS have tremendous societal and economic ramifications, making it imperative to develop effective strategies for preventing and controlling it to alleviate this growing burden. Periodontal disease and MetS are associated with several risk factors. Studies in the past have demonstrated that obesity, cardiovascular illness, and type 2 diabetes mellitus have a negative effect on the severity of periodontal disease. Patients with metabolic syndrome have elevated serum levels of proinflammatory mediators such as tumour necrosis factor-alpha interleukin-6 and C-reactive protein. Remarkably, Intermittent fasting is underpinned by scientific evidence, claiming to be the most effective non-pharmacological, potential therapeutic alternative for combating a wide range of metabolic, inflammatory, and lifestyle-related diseases.
  • 544
  • 17 Nov 2022
Topic Review
Liquid Biopsy in Cancer
Liquid biopsy (LBx) is a novel and promising approach in precision medicine, suitable for patient management in a wide range of medical conditions. Its utility in oncology ranges from disease screening to early diagnosis and treatment. LBx has several strengths, such as safeness, quickness of execution, and repeatability, compared to old-fashioned solid biopsy techniques; indeed, LBx requires the collection of a small number of biospecimens. LBx has been proven to be accurate and reliable, as demonstrated in several clinical studies, and it could have a surprising impact on survival and quality of life for cancer patients in the near future.
  • 483
  • 17 Nov 2022
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