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Topic Review
The Association between Physical Environment and Externalising Problems
The physical environment is of critical importance to child development. Understanding how exposure to physical environmental domains such as greenspace, urbanicity, air pollution or noise affects aggressive behaviours in typical and neurodiverse children is of particular importance given the significant long-term impact of those problems.Noise, air pollution, urbanicity, spatial density, colour and humidity appeared to increase the display of aggressive behaviours. There was a dearth of studies on the role of the physical environment in neurodiverse children. Studies were heterogeneous and measured a range of aggressive behaviours from symptoms to full syndromes. Greenspace exposure was the most common domain studied but certainty of evidence for the association between environmental exposures and aggression problems in the child or young person was low across all domains. 
  • 401
  • 15 Feb 2023
Topic Review
Parental Influences on Children’s Eating Behaviours
Children's eating behaviours are influenced by both genetic and environmental factors. Parents appear to play a pivotal role in their development as the main responsible for shaping their children’s feeding environment and eating experiences. This influence begins even before birth, with exposure in utero, and continues throughout childhood, as parents provide the foods offered and interact with their children during mealtimes. However, the parent-child relationship is likely reciprocal as children's behaviours can also influence parental choices.
  • 340
  • 15 Feb 2023
Topic Review
Anti-Obesity Effects of Natural Constituents
Obesity is a chronic metabolic complication, and its management requires long-term medication, lifestyle modifications, and dietary interventions. Patients taking anti-obesity medications may suffer from side effects such as psychiatric disorders, anxiety, depression, and vitamin deficiency. Various classes of natural compounds are promising agents to combat the obesity pandemic. Developing safer drugs may require polytherapeutic strategies to combat the global obesity pandemic.
  • 594
  • 14 Feb 2023
Topic Review
Earthquake-Triggered Respiratory Infectious Diseases
Earthquakes are among the most impressive natural phenomena with very high potential to set off a chain of effects that significantly affects public health. Related disasters are attributed not only to the strong ground motion and coseismic phenomena but also to secondary effects, comprising mainly landslides and tsunamis, among others. All these can create harsh conditions favorable for the emergence of infectious diseases.
  • 882
  • 14 Feb 2023
Topic Review
Training for Food Handlers in Italian Regions
Food safety has always been a public health challenge. Globally, food safety control is supported by laws and preventive measures, such as inspections conducted from primary production to market, “from farm to fork” as emphasized by the European Union and training of Food Handlers (FHs). This latter preventive measure plays a very important role, and for this reason a review of training courses regulations provided in the different Italian regions was conducted. 
  • 258
  • 14 Feb 2023
Topic Review
Impact of COVID-19 on Mental Health in Adolescents
Globally, adolescents of varying backgrounds experience higher rates of anxiety, depression, and stress due to the pandemic. Secondly, adolescents also have a higher frequency of using alcohol and cannabis during the COVID-19 pandemic. However, social support, positive coping skills, home quarantining, and parent–child discussions seem to positively impact adolescent mental health during this period of crisis. Whether in the United States or abroad, the COVID-19 pandemic has impacted adolescent mental health. Therefore, it is important to seek and to use all of the available resources and therapies to help adolescents mediate the adjustments caused by the pandemic.
  • 274
  • 13 Feb 2023
Topic Review
Lipoxygenases and Arachidonic Acid in Glioblastoma Multiforme
Glioblastoma multiforme is a brain tumor with a very unfavorable prognosis, where the vast majority of patients do not survive a year after diagnosis. Arachidonic acid ARA C20:4n-6 in humans is not synthesized de novo but from linoleic acid C18:2n-6 in the polyunsaturated fatty acid (PUFA) biosynthesis pathway. In addition to the cyclooxygenases (COX) pathway, PUFA can be transformed with lipoxygenases (LOX). These enzymes exhibit dioxygenase activity, catalyzing the insertion of a hydroperoxyl group into a PUFA, most commonly ARA 20:4n-6.
  • 583
  • 10 Feb 2023
Topic Review
Static Stretching Exercises
The utility of flexibility as a standard component of physical fitness has recently been questioned, sparking a heated debate among scientists. Rsearchers conducted a narrative review of the existing knowledge and concluded that flexibility deserves to be further considered as a standard component of physical fitness. This is based on the findings that in addition to flexibility, long-term static stretching training induces positive effects on muscle strength, muscle power, and muscle hypertrophy, irrespective of age and sex. There are also indications that long-term static stretching training could mitigate the risk of injury. Furthermore, promising evidence shows that combining resistance training with static stretching exercises constitutes an effective approach benefiting muscle strength and hypertrophy more than resistance training alone. Overall, researchers would not support the recent suggestion that flexibility should be retired as a standard component of physical fitness and researchers would advocate for a continuous emphasis on the prescription of stretching exercises.
  • 387
  • 10 Feb 2023
Topic Review
Mutual Regulatory Mechanisms between N6-metyladenosine Modification and miRNAs
N6-metyladenosine (m6A), one of the most common RNA methylation modifications in mammals, has attracted extensive attentions owing to its regulatory roles in a variety of physiological and pathological processes. As a reversible epigenetic modification on RNAs, m6A is dynamically mediated by the functional interplay among the regulatory proteins of methyltransferases, demethylases and methyl-binding proteins. It has become increasingly clear that m6A modification is associated with the production and function of microRNAs (miRNAs).
  • 510
  • 10 Feb 2023
Topic Review
Regulation of Central and Peripheral Blood Pressure
Pressure in the primary arteries near the heart and the brain is known as central blood pressure (CBP), while that in the peripheral arteries is known as peripheral blood pressure (PBP). Usually, CBP and PBP are correlated. However, various types of shocks and cardiovascular disorders interfere with their regulation, and consequently, their correlation is lost. Therefore, understanding blood pressure in normal and disease conditions is essential for managing shock-related cardiovascular implications and improving treatment outcomes. 
  • 635
  • 10 Feb 2023
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