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Topic Review
Exploring Olive Pomace for Skincare Applications
The olive oil industry generates a large amount of liquid and semi-solid by-products such as olive pomace. Their phytotoxicity impairs safe disposal, so valorization strategies that promote by-product reuse are needed, which may include skincare products. Hydroxytyrosol is the main phenolic compound present in olive pomace and possesses biological effects that make it a desirable active compound for cosmetic formulations such as antioxidant and anti-aging activities as well as photoprotector, depigmenting, antimicrobial and anti-inflammatory actions. Other compounds present in olive pomace can also have functional properties and skin-related benefits. However, the application of this by-product can be a challenge in terms of formulation’s design, stability, and proven efficacy, so appropriate methodologies should be used to validate its incorporation and may include extraction and further encapsulation of bioactive compounds in order to achieve effective and aesthetic appealing skincare products.
  • 333
  • 17 Mar 2023
Topic Review
Human-Centric Approach in Healthcare 4.0
The cyberspace depicts an increasing number of difficulties related to security, especially in healthcare. This is evident from how vulnerable critical infrastructures are to cyberattacks and are unprotected against cybercrime. Users, ideally, should maintain a good level of cyber hygiene, via regular software updates and the development of unique passwords, as an effective way to become resilient to cyberattacks. Cyber security breaches are a top priority, and most users are aware that their behaviours may put them at risk; however, they are not educated to follow best practices, such as protecting their passwords. Mass cyber education may serve as a means to offset poor cyber security behaviours; however, mandatory education becomes a questionable point if the content is not focused on human factors, using human-centric approaches and taking into account end users’ behaviours, which is currently the case. Papers report the best practices that should be used by healthcare organisations and healthcare professionals to maintain good cyber hygiene and how these can be applied via a healthcare use case scenario to increase awareness related to data privacy and cybersecurity. This is an issue of great importance and urgency considering the rapid increase of cyberattacks in healthcare organisations, mainly due to human errors. Further to that, based on human-centric approaches, the long-term vision and future work involves facilitating the development of efficient practices and education associated with cybersecurity hygiene via a flexible, adaptable and practical framework.
  • 301
  • 17 Mar 2023
Topic Review
Non-Steroidal Anti-Inflammatory Drugs in the Fight against COVID-19
In Italy, a flowchart to be used by General Practitioners for the at-home treatment of patients with COVID-19, has been released. It states that early at-home treatment for SARS-CoV-2 infection is possible due to the availability of specific antiviral drugs to be used in at-risk patients, and that non-steroidal anti-inflammatory drugs (NSAIDs) have an important function in combating the virus. Therefore, the use of NSAIDs is not only rational but also effective in cases that cannot be treated using antivirals. 
  • 1.1K
  • 17 Mar 2023
Topic Review
Systematic Approach in Digital Health Transformation in Healthcare
The COVID-19 pandemic has sped up digital health transformation across the health sectors to enable innovative health service delivery. Such transformation relies on competent managers with the capacity to lead and manage. Sustainable, quality, and safe healthcare services require a management workforce equipped with contemporary leadership and management capabilities. With the ever-changing landscape of digital health, health service managers are required to lead and manage in times of system transformation. Digital competencies are required for the health service management (HSM) profession as well as the general healthcare workforce, which needs collaborative efforts across healthcare organizations, government, educational, and professional institutions. Management workforce capacity-building needs to adopt a holistic approach to developing the requisite HSM capabilities and system-wide capacity, which may include appropriate policy, supportive organizational systems and structure, and aligned education and training offerings. HSM workforce development is not a one-off effort. It requires system-level investment, support, and recognition, and collective efforts in removing the barriers and hurdles to the ongoing development of required digital health competencies and capabilities.
  • 390
  • 16 Mar 2023
Topic Review
Bone Mass and Mineral Metabolism in Celiac Disease
Osteoporosis affects many patients with celiac disease (CD), representing the consequence of calcium malabsorption and persistent activation of mucosal inflammation. A slight increase of fracture risk is evident in this condition, particularly in those with overt malabsorption and in postmenopausal state. The adoption of a correct gluten-free diet (GFD) improves bone derangement, but is not able to normalize bone mass in all the patients. Biomarkers effective in the prediction of bone response to gluten-free diet are not available and the indications of guidelines are still imperfect and debated.
  • 362
  • 16 Mar 2023
Topic Review
Impact of COVID-19 Confinement on Vulnerable Populations
The confinement caused by the pandemic has been especially hard for young people belonging to certain vulnerable populations and it has had a greater impact on previously existing pathologies and on those that have appeared because of this period. There was an increase in the diagnosis of mood disorders and the use of medication associated with these disorders, mainly during the period of reclusion that was declared worldwide in March 2020. In addition, risk factors such as loneliness, a lack of resilience, and a lack of adequate coping strategies negatively impacted these groups. 
  • 296
  • 15 Mar 2023
Topic Review
Congo Red Toxicity towards Different Living Organism
Congo-red (CR) is an azo dye with the molecular formula of C32H22N6Na2O6S2 and molecular weight = 696.68 g mol−1. Paul Bottinger discovered CR as the first direct dye in 1884. It is an anionic di-azo dye (contains two groups -N=N-) composed of a sodium salt of benzidinediazo-bis-1-naphthylamine-4-sulfonic acid, known by common names such as CR 4B, C.I. 22120, Cotton red B, Cotton red C, Direct red 28, Cosmos red, Direct red Y, and Direct red R.
  • 833
  • 15 Mar 2023
Topic Review
Exercise Timing on Fat Oxidation during Exercise
Due to increasingly diverse lifestyles, exercise timings vary between individuals: before breakfast, in the afternoon, or in the evening. The endocrine and autonomic nervous systems, which are associated with metabolic responses to exercise, show diurnal variations. Moreover, physiological responses to exercise differ depending on the timing of the exercise. The postabsorptive state is associated with greater fat oxidation during exercise compared to the postprandial state. The increase in energy expenditure persists during the post-exercise period, known as “Excess Post-exercise Oxygen Consumption”.
  • 292
  • 15 Mar 2023
Topic Review
Problems Associated with Moulds in Foodstuffs
Two downsides associated with the mould contamination of food are of interest: spoilage and mycotoxin production provoking food quality and food safety concerns, respectively.
  • 433
  • 13 Mar 2023
Topic Review
The Microbiome and Cancer Development
Changes in the microbiome also induce complex changes in human cells. From a biological perspective, the normal cervicovaginal microbiome is composed mainly of Lactobacillus spp., thus exhibiting low bacterial diversity and protecting against carcinogenesis through various mechanisms. The lactobacilli secrete lactic acid, and the low vaginal pH promotes healthy local homeostasis. The lactobacilli also secrete cytokines, antimicrobial peptides, and other metabolites that protect the local epithelium. They promote a healthy level of physiological inflammation that stimulates the immune system to fight against pathogens. On the other hand, the dysbiotic cervicovaginal microbiome exhibits a high diversity of microorganisms, primarily obligate and strict anaerobes, that lead to a high vaginal pH. The bacteria promote the disruption of the epithelial barrier and secrete various metabolites and enzymes such as sialidase, proinflammatory cytokines and chemokines, reactive oxygen species, and other carcinogenic metabolites that lead to chronic inflammation and a dysregulated local metabolism. Further down the line, they also lead to genotoxicity and genomic instability, as well as altered proliferation and altered apoptosis. The dysbiotic environment also promotes angiogenesis. The chronic inflammation activates immune cells that secrete even more proinflammatory cytokines and chemokines such as Interleukin (IL)-6, IL-8 or Tumor necrosis factor (TNF), resulting in even more reactive oxygen species that further promote carcinogenic mechanisms. Hence, there are many different mechanisms through which the microbiota can impact carcinogenesis.
  • 306
  • 13 Mar 2023
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