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Topic Review
OTFT Monitoring in Complex Body Fluid Environments
People are becoming more concerned about their physical health and putting forward higher requirements for an early and painless diagnosis of diseases. Traditional methods, such as surface plasmon resonance (SPR), enzyme-linked immunosorbent assay (ELISA), surface-enhanced raman spectroscopy (SERS), and colorimetric methods have been used for the detection of biomarkers with high selectivity and sensitivity; however, these methods still need to be further improved for immediate and rapid diagnosis. Herein, organic thin-film transistors (OTFTs)-based biosensors offer the advantages of good flexibility, low-cost fabrication, reasonable sensitivity, and great biocompatibility for efficient determination of biomarkers in complex samples, including saliva, sweat, urine, and blood, respectively, exhibiting great potential in early disease diagnosis and clinical treatment.
  • 268
  • 11 Apr 2023
Topic Review
Bioactive Mycocompounds of Selected Medicinal Mushrooms for HPV
Medicinal mushrooms have been used as a medicinal tool for many centuries and, nowadays, are used in the prevention and therapy of various diseases, including as an adjunct to cancer treatment. It is estimated that 14–16% of global cancer cases are caused by infectious events; one well-known infectious agent that leads to cancer is the human papillomavirus (HPV). HPV is responsible for more than 99.7% of cervical cancer cases and also may play a role in vaginal, vulvar, penile, anal, rectal, and oropharyngeal carcinogenesis. Coriolus versicolor, a basidiomycetes class mushroom, consists of glycoproteins called polysaccharide-K (PSK) and polysaccharopeptide (PSP), which are mainly responsible for its effectiveness in the fight against a variety of cancers. Its beneficial effect lies in its ability to arrest different phases of the cell cycle, immunomodulation or induction of apoptosis. Coriolus versicolor extractcan reduces BCL-2 expression or increases the expression of p53 tumour suppressor genes in breast tumour cell lines. Inhibition of proliferation was also demonstrated with HeLa cells, while cervical cytology abnormalities improved in patients who locally applied Coriolus versicolor-based vaginal gel. Coriolus versicolor extract itself, and also its combination with another medicinal mushroom, Ganoderma lucidum, leads to improved HPV clearance in HPV cervical or oral-positive patients. Medicinal mushrooms can also increase the effectiveness of vaccination.
  • 445
  • 11 Apr 2023
Topic Review
Rapid Oral Heath Deterioration
Poor oral health is a common morbidity in old age with older adults less likely to attend dental care and more likely to have dental disease; this situation is exacerbated by older adults retaining more teeth often with complex restorations.
  • 257
  • 10 Apr 2023
Topic Review
Target Biological Properties of Cosmetic Ingredients
Cosmetics are, per definition, any substance or mixture intended to be placed in contact with the external parts of the human body (epidermis, hair, nails, lips, and external genital organs) or with teeth or with the membranes of the oral cavity with the sole or main purpose to clean, perfume, change their appearance, protect, keep good condition, or alter body odors. Cosmetic products with biologically active ingredients are formulated to improve appearance and boost positive physiological effects at the cellular level, and there is a high demand for these ingredients.
  • 459
  • 06 Apr 2023
Topic Review
Diagnosis and Prognosis of Food Selectivity in Autism
Autisms Spectrum Disorders (ASD) are characterized by core symptoms (social communication and restricted and repetitive behaviors) and related comorbidities, including sensory anomalies, feeding issues, and challenging behaviors. Children with ASD experience significantly more feeding problems than their peers. In fact, parents and clinicians have to manage daily the burden of various dysfunctional behaviors of children at mealtimes (food refusal, limited variety of food, single food intake, or liquid diet). These dysfunctional behaviors at mealtime depend on different factors that are either medical/sensorial or behavioral. 
  • 478
  • 06 Apr 2023
Topic Review
Sentiment Analysis of E-News in Public Health Crisis
Public awareness campaigns play a pivotal role in disseminating relevant information on health promotion and disease prevention, especially to key populations. Sentiment analysis can be defined as the task of extracting subjective information about sentiments (positive, negative, or neutral) from different sources. Texts, biometric data, comments on social networks, product feedback, and others are examples of sources. This analysis allows us to know factors that influence certain social phenomena and can be used, for example, to verify the acceptance of a given product or even to understand how the target audience perceives marketing messages.
  • 315
  • 06 Apr 2023
Topic Review
Physical Activity and Mediterranean Diet in Cancer
A healthy diet and an active lifestyle are both effective ways to prevent, manage, and treat many diseases, including cancer. A healthy, well-balanced diet not only ensures that the body gets the right amount of nutrients to meet its needs, but it also lets the body get substances that protect against and/or prevent certain diseases. It is now clear that obesity is linked to long-term diseases such as heart disease, diabetes, and cancer.
  • 308
  • 06 Apr 2023
Topic Review
Probiotics and Prebiotics Concepts
Probiotics are microorganisms which, if taken in sufficient quantities, contribute positively to the health of the host and are the focus of both scientific studies and commercial companies. 
  • 415
  • 06 Apr 2023
Topic Review
The Influence of Heavy Metal
There are a multitude of sources of heavy metal pollution which have unwanted effects on this super organism, the soil, which is capable of self-regulation, but limited. Living a healthy life through the consumption of fruits and vegetables, mushrooms, edible products and by-products of animal origin, honey and bee products can sometimes turn out to be just a myth due to the contamination of the soil with heavy metals whose values, even if they are below accepted limits, are taken up by plants, reach the food chain and in the long term unbalance the homeostasis of the human organism. Plants, these miracles of nature, some with the natural ability to grow on polluted soils, others needing a little help by adding chelators or amendments, can participate in the soil detoxification of heavy metals through phytoextraction and phytostabilization.
  • 502
  • 04 Apr 2023
Topic Review
Children with Attention Deficit Hyperactivity Disorder
Children with attention deficit hyperactivity disorder are characterized by inattention, hyperactivity, impulsivity, difficulty in controlling behavior, or such comprehensive symptoms, while children with ASD have apparent deficits in social communication skills and repetitive stereotyped behavior patterns. Despite significant differences in the core symptoms between children with ADHD and ASD, clinical studies have supported the similarity of the behavioral disorders, and the findings suggest that the two types of children not only have highly shared heritability, but also represent the performance of the same endophenotype and can be classified into the same diagnostic entity.
  • 248
  • 03 Apr 2023
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