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Topic Review
Longevity Blue Zones
Longevity is rightly considered one of the greatest achievements of modern society, not only as a function of lifespan, but, more importantly, as a function of healthspan. There are Longevity Blue Zones (LBZs), regions around the world, such as in Okinawa, Japan; the Nicoya Peninsula, Costa Rica; Loma Linda, California; Icaria, Greece; and Ogliastra, Sardinia, that are characterized by a significant percentage of residents who live exceptionally long lives, often avoiding age-related disability to a significantly higher degree than in the Western way of life. Longevity is not a universal phenomenon, so if there are places in the world with characteristics similar to the LBZs, it is important to identify them in order to better understand what other factors, in addition to the known ones, might contribute to a long and healthy life. 
  • 284
  • 06 Mar 2024
Topic Review
Mendelian Susceptibility to Mycobacterial Disease
The diagnosis and treatment of patients with mendelian susceptibility to mycobacterial disease (MSMD) pose consistent challenges due to the diverse infection spectrum observed in this population. Common clinical manifestations include Bacillus Calmette-Guérin vaccine (BCG) complications in countries where routine BCG vaccination is practiced, while in non-BCG-vaccinating countries, Non-Tuberculous Mycobacteria (NTM) is prevalent. In tuberculosis-endemic regions, Mycobacterium tuberculosis (MTB) has a high prevalence, along with other intracellular organisms.
  • 240
  • 06 Mar 2024
Topic Review
Associations between Childhood Abuse and Adult Psychopathology
Research consistently shows that abuse during childhood is related to adult psychopathology. Adverse childhood experiences, including emotional, physical, and sexual abuse, have been consistently linked to mental health problems in children and adults.
  • 76
  • 05 Mar 2024
Topic Review
Artificial Intelligence Advancements in Cervical Cancer
Artificial intelligence has yielded remarkably promising results in several medical fields, namely those with a strong imaging component. Gynecology relies heavily on imaging since it offers useful visual data on the female reproductive system, leading to a deeper understanding of pathophysiological concepts. The applicability of artificial intelligence technologies has not been as noticeable in gynecologic imaging as in other medical fields. However, due to growing interest in this area, some studies have been performed with exciting results. From urogynecology to oncology, artificial intelligence algorithms, particularly machine learning and deep learning, have shown huge potential to revolutionize the overall healthcare experience for women’s reproductive health.
  • 81
  • 05 Mar 2024
Topic Review
Promoting Health among Children and Adolescents via Gamification
The rapid growth in digital technology usage among children and adolescents has highlighted the need for novel approaches to promote their physical and mental health. Promoting children and adolescents’ physical and mental health through gamified techniques, these interventions can provide an interactive and engaging platform for encouraging physical activity, promoting healthy nutrition, enhancing emotional regulation, and promoting mental health. The significance of this topic stems from the pervasive use of electronic games, beginning at a young age, which makes them popular educational tools.
  • 196
  • 05 Mar 2024
Topic Review
LGBT Persons, COVID-19 and HIV/AIDS
COVID-19 has often been described as the first pandemic in over a century. In fact, there have been others, including the Spanish Flu of 1918–1920, tuberculosis in the late 19th century; polio in the 1950s; SARS in 2002; the H1N1 influenza pandemic in 2009–2010; and HIV/AIDS, first identified in the early 1980s and continuing as a major public health issue. These previous epidemics and pandemics exist as context for many of those now confronting COVID-19.
  • 119
  • 05 Mar 2024
Topic Review
Lycium barbarum Deep-Processing Products of Fermentation
Lycium barbarum, a homology of medicine and food, contains many active ingredients including polysaccharides, polyphenol, betaine, and carotenoids, which has health benefits and economic value. The bioactive components in Lycium barbarum exhibit the effects of antioxidation, immune regulation, hypoglycemic effects, and vision improvement.
  • 102
  • 04 Mar 2024
Topic Review
Minimally Invasive Capsule Panendoscopy
In the early 2000s, the introduction of single-camera wireless capsule endoscopy (CE) redefined small bowel study. Progress continued with the development of double-camera devices, first for the colon and rectum, and then, for panenteric assessment. Advancements continued with magnetic capsule endoscopy (MCE), particularly when assisted by a robotic arm, designed to enhance gastric evaluation.
  • 212
  • 04 Mar 2024
Topic Review
Application in Small-Bowel Capsule Endoscopy
The role of capsule endoscopy and enteroscopy in managing various small-bowel pathologies is well-established. However, their broader application has been hampered mainly by their lengthy reading times. As a result, there is a growing interest in employing artificial intelligence (AI) in these diagnostic and therapeutic procedures, driven by the prospect of overcoming some major limitations and enhancing healthcare efficiency, while maintaining high accuracy levels.
  • 147
  • 04 Mar 2024
Topic Review
Ankyloglossia as a Barrier to Breastfeeding
Ankyloglossia, commonly referred to as tongue-tie, brings about functional difficulties and, in some cases, may lead to early weaning. It is crucial to use breastfeeding as the exclusive food source for the first six months of an infant’s life, and the interference of the tongue contributes substantially to success in this regard. Even though there are many publications about ankyloglossia, there are still many controversies about its definition, diagnosis, classification, and treatment decision determined via frenotomy.
  • 195
  • 01 Mar 2024
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