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Topic Review
Biography
Topic Review
Gait Monitoring and Analysis
Gait abnormalities are common in the elderly and individuals diagnosed with Parkinson’s, often leading to reduced mobility and increased fall risk. Monitoring and assessing gait patterns in these populations play a crucial role in understanding disease progression, early detection of motor impairments, and developing personalized rehabilitation strategies. In particular, by identifying gait irregularities at an early stage, healthcare professionals can implement timely interventions and personalized therapeutic approaches, potentially delaying the onset of severe motor symptoms and improving overall patient outcomes.
132
25 Sep 2023
Topic Review
HDAC Inhibitors as Antiparasitic Agents
Ongoing therapy for human parasite infections has a few known drugs but with serious side effects and the problem of drug resistance, impelling us to discover novel drug candidates with newer mechanisms of action. Universally, this has boosted the research in the design and development of novel medicinal agents as antiparasitic drugs with a novel mode of action. Histone deacetylase inhibitors (HDACis) are used in a vast variety of diseases due to their anti-inflammatory properties. Drug repurposing strategies have already approved HDACis as cancer therapeutics and are now under investigation for many parasitic infections. Along with the expression of the gene, histone deacetylase (HDAC) enzymes also act as a slice of great multi-subunit complexes, targeting many non-histones, changing systemic and cellular levels signaling, and producing different cell-based specified effects. Zinc (Zn2+)- and nicotinamide adenine dinucleotide (NAD+)-dependent HDACs of parasites play pivotal roles in the alteration of gene expression of parasites. Some of them are already known to be responsible for the survival of several parasites under odd circumstances; thus, targeting them for therapeutic interventions will be novel for potential antiparasitic targets.
132
25 Jan 2024
Topic Review
Human Activity Recognition and Fall Detection
In health monitoring systems for the elderly, a crucial aspect is unobtrusively and continuously monitoring their activities to detect potentially hazardous incidents such as sudden falls as soon as they occur. However, the effectiveness of current non-contact sensor-based activity detection systems is limited by obstacles present in the environment. To overcome this limitation, a straightforward yet highly efficient approach involves utilizing multiple sensors that collaborate seamlessly.
132
07 Feb 2024
Topic Review
Neurogenic Bone Loss after Spinal Cord Injury
Osteoporosis is a common skeletal disorder which can severely limit one’s ability to complete daily tasks due to the increased risk of bone fractures, reducing quality of life. Spinal cord injury (SCI) can also result in osteoporosis and sarcopenia.
128
28 Sep 2023
Topic Review
The Epidemiology of Osteoporosis in Men
Osteoporosis is called the ‘silent disease’ because, although it does not give significant symptoms when it is not complicated, can cause fragility fractures with severe short and long-term consequences until premature death. Men experiencing hip fractures have a higher likelihood of premature death than women during the hospital stay as well as after years from index event.
128
11 Sep 2023
Topic Review
Surgical Treatment of Acute Ankle Injury
Ankle sprains are exceedingly common injuries in both athletes and the general population. They account for 10 to 30% of all sports injuries. Although the vast majority of lateral ankle ligament injuries respond successfully to conservative management, the absolute number of those that progress to chronic lateral ankle instability (CLAI) remains considerably important. This condition is characterized by persistent symptoms and may be associated with short-term and long-term complications and functional deficits.
125
16 Jan 2024
Topic Review
Developing Cardio-Oncology Programs in the New Era
Modern cancer therapies have achieved a remarkable improvement in overall survival and patients’ quality of life. However, cardiovascular toxicities are still a major concern. A specific Cardio-Oncology unit is key to offering patients with cancer the best approaches to treatment while minimizing adverse cardiac effects. Moreover, this area of medicine requires a large expertise and has limited trials on which to base decision-making. The development of structured Cardio-Oncology programs leads to better patient care and generates scientific evidence that may impact patient’s survival outcomes.
125
02 Jan 2024
Topic Review
Diagnostic Tests for SARS-CoV-2 in South African Population
The unprecedented spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in the urgent need for rapid and reliable diagnostic tests. Accurately diagnosing individuals with infection was paramount to limit the transmission of the virus and to reduce morbidity and mortality.
121
08 Dec 2023
Topic Review
Health Transport Demand
Efficient planning and management of health transport services are crucial for improving accessibility and enhancing the quality of healthcare. Specifically, health transport services data from Asturias, spanning a seven-year period, are analyzed with the aim of developing accurate predictive models.
121
31 Jan 2024
Topic Review
Postprandial Exercise in Mitigating Glycemic Responses
Engaging in some forms of exercise following a meal is effective in mitigating postprandial hyperglycemia and assisting with daily glycemic control. The improved glycemic response observed in studies using diverse exercise protocols suggests that an exercise strategy aimed at reducing blood glucose response can be readily applied without being constrained by the availability of exercise equipment or the functional capacity of an individual, as long as the exercise duration is sufficient (i.e., >30 min).
116
08 Nov 2023
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