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Topic Review
Hypoxia in Cardiovascular Diseases
Heart valve diseases are a major contributor to cardiovascular morbidity and mortality worldwide. They affect more than 13% of the population aged over 75 years old and occur when any type of the four heart valves (tricuspid, pulmonic, mitral, and aortic valves) is damaged. Calcific aortic valve disease (CAVD) is defined as a slowly progressing condition that ranges from mild valve aortic sclerosis to severe calcifying aortic valve stenosis. This progression manifests in approximately 2% of individuals over 65 years old annually.
  • 288
  • 20 Jul 2023
Topic Review
Avian Influenza Virus: Genomic Epidemiology
Avian influenza virus (AIV) poses a significant challenge to poultry production, with negative repercussions for both the economy and public health worldwide. Since January 2003, a total of 868 human cases of AIV H5N1 have been reported from four countries in the Western Pacific Region, as of 9 March 2023. When AIVs are circulating in poultry, there is a risk of sporadic infections and small clusters of human cases due to exposure to infected poultry or contaminated environments.
  • 287
  • 15 Jun 2023
Topic Review
Emergency Department Care Experiences
Emergency departments (EDs) are an important source of care for people with mental health (MH) concerns. It can be challenging to treat MH in EDs, and there is little research capturing both patient and provider perspectives of these experiences. 
  • 287
  • 28 Jul 2022
Topic Review
Whole Genome Sequence of Mycobacterium tuberculosis
Tuberculosis (TB) remains one of the most significant global health problems, posing a significant challenge to public health systems worldwide. However, diagnosing drug-resistant tuberculosis (DR-TB) has become increasingly challenging due to the rising number of multidrug-resistant (MDR-TB) cases, despite the development of new TB diagnostic tools. Even the World Health Organization-recommended methods such as Xpert MTB/XDR or Truenat are unable to detect all the Mycobacterium tuberculosis genome mutations associated with drug resistance. While Whole Genome Sequencing offers a more precise DR profile, the lack of user-friendly bioinformatics analysis applications hinders its widespread use.
  • 287
  • 04 Aug 2023
Topic Review
The African Wastewater Resistome
In Africa, the prevalence of Antimicrobial Resistance (AMR)  in wastewater is of particular concern due to the inadequate sanitation and wastewater treatment facilities, coupled with the overuse and misuse of antibiotics in healthcare and agriculture. 
  • 286
  • 10 May 2023
Topic Review
Low-Grade Inflammation and Ultra-Processed Foods Consumption
Inflammation is an immunosurveillance response essential for host defense, which serves to repair damaged tissues and eliminate toxic agents. When this response becomes chronic, it results in the presence of immune system cells for an increasing period of time. This state of low-grade inflammation can lead to dysmetabolic conditions that disrupt homeostasis, favoring the development of a wide range of noncommunicable diseases such as cancer, diabetes and cardiovascular diseases. Particular attention has been paid to the increased consumption of ultra-processed foods (UPF) worldwide. Characterized by being hyperpalatable, affordable and ready-to-eat, UPF have led to a worsening of the diet quality due to their nutritional composition and have already been recognized as a risk factor for diet-related diseases.
  • 286
  • 29 Mar 2023
Topic Review
Evidence of Disaster Planning by Home Care Providers
The increasing risk of disasters worldwide poses challenges both to health care infrastructures and to home care providers, who must maintain decentralised services for those in need of long-term care for as long as possible, even under adverse circumstances. However, both the kind of organisational precautions that home care providers consider in preparation for disasters and the available evidence on the effectiveness of these precautions remain largely unclear.
  • 286
  • 22 May 2023
Topic Review
Relationships between Depression and Social Media Addiction
Depression is positively correlated with fear of missing out, online fear of missing out, and social media addiction, while being significantly negatively correlated with self-esteem; that depression, self-esteem, fear of missing out, and online fear of missing out explain social media addiction scores; that self-esteem mediates the relationship between depression and social media addiction; and that, among Italians between the ages of 18 and 35, younger women report higher scores on fear of missing out, online fear of missing out, and social media addiction.
  • 287
  • 15 Jun 2023
Topic Review
Research Trends of Physical Activity during Pregnancy
Physical activity (PA) during pregnancy has been proven beneficial to pregnant women, with a significant effect on ameliorating many severe gestational complications. Improvement of sedentary behaviour, lifestyle intervention through leisure-time PA, and preterm care are major research frontiers and have received extensive attention. 
  • 285
  • 21 Nov 2022
Topic Review
Endothelial Function Evaluation on Pregnant COVID-19 Patients
Pregnancy with SARS-CoV-2 infection can raise the risk of many complications, including severe COVID-19 and maternal–fetal adverse outcomes. Additionally, endothelial damage occurs as a result of direct SARS-CoV-2 infection, as well as immune system, cardiovascular, and thrombo-inflammatory reactions. The endothelium is the key regulator of vascular homeostasis, as it determines vascular tone, smooth muscle cell proliferation, vessel wall inflammation, and platelet aggregation.
  • 284
  • 14 Sep 2023
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