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All Topic Review Biography
Topic Review
Community-Based Prevention and Control of Public Health Events
The so-called community is a living community with stable physical boundaries and common value orientation. Compared with the more common definition of the community as a physical carrier, the community has gradually become the dominant tool to deal with public health emergencies in methodology. On the one hand, from the perspective of the physical attributes of the community, as the most normal living place for ordinary people, the community carries the temporary response to the current sudden public crisis. On the other hand, from the perspective of the social attributes of the community, the recessive resources within the community, such as the trust capital within the community, have played an assisting and supplementary role in the recovery of mental health after a public health crisis to a certain extent.
  • 412
  • 28 Jul 2022
Topic Review
Systematic Approach in Digital Health Transformation in Healthcare
The COVID-19 pandemic has sped up digital health transformation across the health sectors to enable innovative health service delivery. Such transformation relies on competent managers with the capacity to lead and manage. Sustainable, quality, and safe healthcare services require a management workforce equipped with contemporary leadership and management capabilities. With the ever-changing landscape of digital health, health service managers are required to lead and manage in times of system transformation. Digital competencies are required for the health service management (HSM) profession as well as the general healthcare workforce, which needs collaborative efforts across healthcare organizations, government, educational, and professional institutions. Management workforce capacity-building needs to adopt a holistic approach to developing the requisite HSM capabilities and system-wide capacity, which may include appropriate policy, supportive organizational systems and structure, and aligned education and training offerings. HSM workforce development is not a one-off effort. It requires system-level investment, support, and recognition, and collective efforts in removing the barriers and hurdles to the ongoing development of required digital health competencies and capabilities.
  • 412
  • 16 Mar 2023
Topic Review
Marine Cyanobacterial Peptides in Neuroblastoma
Neuroblastoma is the most prevalent extracranial solid tumor in pediatric patients, originating from sympathetic nervous system cells. Metastasis can be observed in approximately 70% of individuals after diagnosis, and the prognosis is poor. The current care methods used, which include surgical removal as well as radio and chemotherapy, are largely unsuccessful, with high mortality and relapse rates. Marine cyanobacteria are a key source of physiologically active metabolites, which have recently received attention owing to their anticancer potential. Marine peptides possess several advantages over proteins or antibodies, including small size, simple manufacturing, cell membrane crossing capabilities, minimal drug–drug interactions, minimal changes in blood–brain barrier (BBB) integrity, selective targeting, chemical and biological diversities, and effects on liver and kidney functions.
  • 412
  • 05 Jun 2023
Topic Review
Transcranial Direct Current Stimulation on Post-Stroke Dysphagia
Dysphagia is one of the most common symptoms in patients after stroke onset, which has multiple unfavorable effects on quality of life and functional recovery. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation that is widely used to improve deglutition function. Recently, some studies have confirmed that tDCS enhances deglutition function after stroke.
  • 412
  • 10 May 2022
Topic Review
Unawareness of Chronic Kidney Disease in Germany
Chronic kidney disease (CKD) is associated with an increased risk for cardiovascular events, hospitalizations, end stage renal disease and mortality. Main risk factors for CKD are diabetes, hypertension, and older age. Although CKD prevalence is about 10%, awareness for CKD is generally low in patients and physicians, hindering early diagnosis and treatment. We analyzed baseline data of 3305 participants with CKD Stages 1–4 from German cohorts and registries collected in 2010. Prevalence of CKD unawareness and prevalence ratios (PR) (each with 95%-confidence intervals) were estimated in categories of age, sex, CKD stages, BMI, hypertension, diabetes and other relevant comorbidities. We used a log-binomial regression model to estimate the PR for CKD unawareness for females compared to males adjusting for CKD stage and CKD risk factors. CKD unawareness was high, reaching 71% (68–73%) in CKD 3a, 49% (45–54%) in CKD 3b and still 30% (24–36%) in CKD4. Prevalence of hypertension, diabetes or cardiovascular comorbidities was not associated with lower CKD unawareness. Independent of CKD stage and other risk factors unawareness was higher in female patients (PR = 1.06 (1.01; 1.10)). Even in patients with CKD related comorbidities, CKD unawareness was high. Female sex was strongly associated with CKD unawareness. Guideline oriented treatment of patients at higher risk for CKD could increase CKD awareness. Patient–physician communication about CKD might be amendable. 
  • 413
  • 18 Nov 2021
Topic Review
Anti-Uterine Fibroids Diet
Uterine fibroids (UFs) are common tumors in women of reproductive age. It is imperative to comprehend UFs’ associated risk factors to facilitate early detection and prevention. Simple relying on surgical/pharmacological treatment of advanced disease is not only highly expensive, but it also deprives patients of good quality of life (QOL). Nutrition plays a crucial role in the management of UFs, adopting a personalized dietary regimen that includes specific foods, supplements, and vitamins can help reduce the risk of UFs, prevent their further growth, and alleviate symptoms. In accordance with the ESCAPE protocol, the incorporation of vitamin D (4000 IU/day), Epigallocatechin Gallate (EGCG) (800 mg/day), and the use of endocrine-disrupting chemical (EDC)-free products can be regarded as both safe and effective. These options also present an economically viable approach, particularly for women who have undergone myomectomy to deter fibroid recurrence, as well as for those exhibiting early symptoms and evident findings on imaging.
  • 412
  • 19 Dec 2023
Topic Review
Risk Factors of Sleep Apnea
Obstructive sleep apnea (OSA), a condition in which there is a recurrent collapse of the upper airway while sleeping, is a widespread disease affecting 5% to 10% people worldwide. Despite several advances in the treatment modalities for OSA, morbidity and mortality remain a concern. Common symptoms include loud snoring, gasping for air during sleep, morning headache, insomnia, hypersomnia, attention deficits, and irritability. Obese individuals, male gender, older age (65+), family history, smoking, and alcohol consumption are well recognized risk factors of OSA.
  • 412
  • 09 Feb 2023
Topic Review
Resistance Training for People with COVID-19
Among different physical exercise models that might help to prevent and treat COVID-19-related conditions, resistance training (RT) might be particularly relevant. Among its benefits, RT can be adapted to be performed in many different situations, even with limited space and equipment, and is easily adapted to an individual’s characteristics and health status.
  • 411
  • 28 Jun 2022
Topic Review
Cardiometabolic-Based Chronic Disease in Czechia
Unlike the traditional adiposity and dysglycemia classifiers, which do not capture the complexity of cardiometabolic pathophysiology, the Cardiometabolic-Based Chronic Disease (CMBCD) model was proposed to incorporate the natural history of the cardiometabolic disease in four stages: 1—risk; 2—pre-disease; 3—diseases; and 4—complications. The CMBCD model combines the dysglycemia and abnormal adiposity drivers into the chronic care model as DBCD  and ABCD, with the presence of earlier primary drivers (genetics, environment, and behavior) and later metabolic drivers (hypertension and dyslipidemia) impacting the eventual cardiovascular disease phenotype. The CMBCD model triggers proactive detection and stratification of subjects at risk using a culturally adapted approach to improve successful implementation and precision. 
  • 411
  • 23 Jul 2021
Topic Review
Immune Responses against SARS-CoV-2—Questions and Experiences
Understanding immune reactivity against SARS-CoV-2 is essential for coping with the COVID-19 pandemic. Herein, we discuss experiences and open questions about the complex immune responses to SARS-CoV-2. Some people react excellently without experiencing any clinical symptoms, they do not get sick, and they do not pass the virus on to anyone else (“sterilizing” immunity). Others produce antibodies, develop memory T cells, and do not get COVID-19 but transmit the virus to others (“protective” immunity). Some people get sick but recover. A varying percentage develops respiratory failure, systemic symptoms, clotting disorders, cytokine storms, or multi-organ failure; they subsequently decease. Some develop long COVID, a new, controversioal pathologic entity similar to fatigue syndrome or autoimmunity. In reality, COVID-19 is considered more of a systemic immune–vascular disease than a pulmonic disease, involving many tissues and the central nervous system. To fully comprehend the complex clinical manifestations, a profound understanding of the immune responses to SARS-CoV-2 is a good way to improve clinical management of COVID-19. Although neutralizing antibodies are an established approach to recognize an immune status, cellular immunity plays at least an equivalent or an even more important role. However, reliable methods to estimate the SARS-CoV-2-specific T cell capacity are not available for clinical routines. This deficit is important because an unknown percentage of people may exist with good memory T cell responsibility but a low number of or completely lacking peripheral antibodies against SARS-CoV-2. Apart from natural immune responses, vaccination against SARS-CoV-2 turned out to be very effective and much safer than naturally acquired immunity. Nevertheless, besides unwanted side effects of the currently available vector and mRNA preparations, concerns remain whether these vaccines will be strong enough to defeat the pandemic. Altogether, discussing important questions, and try to give answers based on the current knowledge and preliminary data from our laboratories. 
  • 411
  • 30 Nov 2021
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