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Topic Review
Retinoic Acid and Retinaldehyde Dehydrogenase
Retinoic acid (RA) is an important biological metabolite synthesized from the retinol content (known as “vitamin A”) via a sequential cellular process in the retinoid signaling pathway (RSP). RSP-mediated RA biosynthesis is a vital physiological process in chordates, since RA interacts with the nuclear receptor superfamily, namely nuclear RA receptors (RARs) and retinoid X receptors (RXRs), bound to the RA response elements (RAREs) in the promoter region of RA target genes. Retinaldehyde dehydrogenases (RALDH) belongs to the oxidoreductase family and plays a critical role in RA synthesis from the retinaldehyde content; therefore, this enzyme is considered to be one of the key regulators of RA-related retinol metabolism and embryonic development.
  • 594
  • 27 Oct 2021
Topic Review
Role of Blockchain Technology in COVID-19 Crisis
To obtain adequate performance in resolving issues that are associated with the COVID-19 pandemic, blockchain can be combined with other available technologies to establish a robust healthcare architecture.
  • 593
  • 29 Jan 2022
Topic Review
COVID-19 Limitations on Doodling in Measuring Burnout
Burnout is a negative, job-related psychological state exhibited through physical fatigue, emotional exhaustion, and loss of motivation. Pre-COVID-19, doodling was identified as a measure of burnout in researchers attending a weekly, in-person health narratives research group manifesting team mindfulness. Doodling was not retained as a possible measure of burnout during COVID-19 once the weekly health narratives research group moved online and aware attention to present perceptions—one aspect of team mindfulness—was no longer evident.
  • 592
  • 17 Dec 2021
Topic Review
Nature’s Role in Outdoor Therapies
Outdoor therapies are intentional therapeutic processes that are (1) place-based, (2) feature active bodily engagement, and (3) recognize nature-human kinship. Significant variety exists in practice, from walk and talk therapy, to expedition-based wilderness therapy, to garden and animal-assisted therapies. These approaches have shown improvement across a wide range of social, emotional, physical, physiological, and psychological outcomes and populations.
  • 591
  • 20 May 2021
Topic Review
oXiris Hemofilter
Critically ill patients with sepsis and severe COVID-19 are commonly characterized by a dysregulated immune response and an acute kidney injury. Continuous renal replacement therapy (CRRT) is proposed as a promising adjuvant therapy to treat these critically ill patients by removing cytokines, pathogen-associated molecular patterns, and damage-associated molecular patterns from the blood. Although multiple hemofilters, including high-cutoff membranes, the oXiris hemofilter, the CytoSorb hemoadsorption device, and the Toraymyxin hemoperfusion cartridge, have been used in clinical practice, the use of the oXiris hemofilter in critically ill patients is of particular interest because it is the only kind of hemofilter that can provide renal replacement therapy, remove endotoxins, and adsorb cytokines simultaneously. 
  • 591
  • 18 Nov 2022
Topic Review
Self-Care Research
Background: Theories can provide a foundation to explain behavior, investigate relationships, and to predict the effect of interventions. The aim of the study was to clarify the use of theories in studies testing interventions to promote self-care. Method: A scoping review. PubMed, EMBASE, PsychINFO, and CINAHL were searched from January 2008 through January 2019. Nine common chronic conditions were included. We included studies testing a self-care intervention if they used a randomized controlled trial design. 
  • 591
  • 08 Jan 2021
Topic Review
Caregiving in Parkinson´s Disease and Deep Brain Stimulation
In Parkinson’s disease (PD) patients, the progressive nature of the disease and the variability of disabling motor and non-motor symptoms contribute to the growing caregiver burden (CB) of PD partners and conflicts in their relationships. In advanced stages of the disease, Deep Brain Stimulation (DBS) improves PD symptoms and patients quality of life but the effect of DBS on CB of PD partners seems to be heterogeneous. The CB in the context of DBS framing both pre-, peri- and postoperative aspects aims to be illuminated, and further recognition of caregiver burden in partners of PD patients with DBS will be stimulated.
  • 591
  • 18 Feb 2022
Topic Review
Mediterranean Diet and Cardiodiabesity
A growing body of scientific evidence shows that the Mediterranean Diet (MedDiet) has a beneficial effect on obesity, metabolic syndrome (MetS), cardiovascular disease (CVD), and type 2 diabetes mellitus (T2DM). These four diseases are so inherently linked that a new umbrella term, cardiodiabesity, has been adopted to reflect their coexistence and interrelationship .
  • 591
  • 08 Oct 2021
Topic Review
Treadmill Training Interventions on Elders with Neurological Disorders
Stroke, one of the most common neurological disorders, is a leading cause of long-term disability in older adults. Brain damage due to stroke can lead to symptoms such as cognitive and motor impairments including pain, paralysis, poor balance, spasticity, muscle weakness, and ineffective gait patterns.
  • 591
  • 25 Mar 2022
Topic Review
The Bacterial Urban Resistome
Cities that are densely populated are reservoirs of antibiotic resistant genes (ARGs). The overall presence of all resistance genes in a specific environment is defined as a resistome. Spatial proximity of surfaces and different hygienic conditions leads to the transfer of antibiotic resistant bacteria (ARB) within urban environments. Built environments, public transportation, green spaces, and citizens’ behaviors all support persistence and transfer of antimicrobial resistances (AMR). 
  • 590
  • 14 Jun 2022
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