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Topic Review
Taxonomy for Skeleton-GNN-Based Human Action Recognition
Human action recognition has been applied in many fields, such as video surveillance and human computer interaction, where it helps to improve performance. Connecting the skeleton joints as in the physical appearance can naturally generate a graph. A new taxonomy for skeleton-GNN-based methods is proposed according to current designs, and the merits and demerits are analyzed.
  • 437
  • 14 Mar 2022
Topic Review
Tax Planning on Tobacco Economy in Europe
Taxes on the consumption of certain products have played a key role in public revenue analysis in European countries. The global market for alternative risk-reduced tobacco products, such as e-cigarettes, heated tobacco products (HTPs), nicotine pouches, and snus, has been rapidly growing. As these products are relatively new, there is a lack of consensus among policymakers on how to regulate them, particularly in terms of taxation.
  • 197
  • 18 Oct 2023
Topic Review
Target Biological Properties of Cosmetic Ingredients
Cosmetics are, per definition, any substance or mixture intended to be placed in contact with the external parts of the human body (epidermis, hair, nails, lips, and external genital organs) or with teeth or with the membranes of the oral cavity with the sole or main purpose to clean, perfume, change their appearance, protect, keep good condition, or alter body odors. Cosmetic products with biologically active ingredients are formulated to improve appearance and boost positive physiological effects at the cellular level, and there is a high demand for these ingredients.
  • 458
  • 06 Apr 2023
Topic Review
Talar Fractures
Talar fractures are associated with relatively poor postoperative outcomes, high rates of AVN, and posttraumatic osteoarthritis. Poor outcomes revealed a positive association with fracture severity. Prospective studies investigating predictors for treatment success and/or failure are urgently needed to improve the overall quality of life and function of patients undergoing surgical treatment due to talar fractures.
  • 484
  • 11 Aug 2021
Topic Review
Tackling Infectious Diseases
Infectious diseases (IDs) are a leading cause of death. The diversity and adaptability of microbes represent a continuing risk to health.
  • 140
  • 13 Mar 2024
Topic Review
T Cells in Metabolic Diseases
Metabolic disease is a kind of multi-system abnormal disease which is manifested by diseases or disorders that disrupt normal metabolism, including hyperglycemia, dyslipidemia, hypertension, obesity, and insulin resistance, and leads to a dramatic increase in the occurrence of cardiovascular diseases such as acute myocardial infarction and stroke. T cells are involved in the inflammatory response, which can also regulate the development of metabolic diseases, CD4+ T cells and CD8+ T cells are mainly responsible for the role.
  • 531
  • 22 Nov 2022
Topic Review
Systematic Approach in Digital Health Transformation in Healthcare
The COVID-19 pandemic has sped up digital health transformation across the health sectors to enable innovative health service delivery. Such transformation relies on competent managers with the capacity to lead and manage. Sustainable, quality, and safe healthcare services require a management workforce equipped with contemporary leadership and management capabilities. With the ever-changing landscape of digital health, health service managers are required to lead and manage in times of system transformation. Digital competencies are required for the health service management (HSM) profession as well as the general healthcare workforce, which needs collaborative efforts across healthcare organizations, government, educational, and professional institutions. Management workforce capacity-building needs to adopt a holistic approach to developing the requisite HSM capabilities and system-wide capacity, which may include appropriate policy, supportive organizational systems and structure, and aligned education and training offerings. HSM workforce development is not a one-off effort. It requires system-level investment, support, and recognition, and collective efforts in removing the barriers and hurdles to the ongoing development of required digital health competencies and capabilities.
  • 388
  • 16 Mar 2023
Topic Review
System Structure of Appointment Scheduling
In the face of an increasingly high-demand environment for outpatients, achieving a balance between allocation of limited medical resources and patient satisfaction has considerable social and economic benefits. Therefore, appointment scheduling (AS) system operation is used in clinics and hospitals, and its operation optimization research is of great significance.
  • 294
  • 23 Feb 2024
Topic Review
Syphilis and COVID-19
The syphilis and COVID-19 pandemics have marked a turning point in the history of mankind. The aim of this review is to analyze what two pandemics caused by different diseases have in common.
  • 551
  • 25 Apr 2023
Topic Review
Synthetic mRNAs
The structure of synthetic mRNAs as used in vaccination against cancer and infectious diseases contain specifically designed caps followed by sequences of the 5′ untranslated repeats of β-globin gene. The strategy for successful design of synthetic mRNAs by chemically modifying their caps aims to increase resistance to the enzymatic deccapping complex, offer a higher affinity for binding to the eukaryotic translation initiation factor 4E (elF4E) protein and enforce increased translation of their encoded proteins. However, the cellular homeostasis is finely balanced and obeys to specific laws of thermodynamics conferring balance between complexity and growth rate in evolution. An overwhelming and forced translation even under alarming conditions of the cell during a concurrent viral infection, or when molecular pathways are trying to circumvent precursor events that lead to autoimmunity and cancer, may cause the recipient cells to ignore their differential sensitivities which are essential for keeping normal conditions. The elF4E which is a powerful RNA regulon and a potent oncogene governing cell cycle progression and proliferation at a post-transcriptional level, may then be a great contributor to disease development. This Fact Sheet underscores the basic elements from within the official text of publication to highlight the hallmarks of disease progression due to synthetic mRNAs stability structures (analogue caps, 5’ untranlslated repeats of β-globin gene and poly A tails) fundamentally used in design of all synthetic mRNAs to promote the efficiency of translation of their encoded sequences by the human cell and therefore the organism. Specific bullet points in bold mean for urgency of further toxicity evaluation studies that need to be overtaken in order to ensure for safety of mRNAs in vaccines at current stages of development.
  • 433
  • 01 Sep 2021
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