Topic Review
Higher Blood Pressure & Neurodegeneration
High Blood Pressure (Hypertension) is a major risk factor for cerebral health. Midlife hypertension is associated with a two- to five-fold increased risk of stroke, and up to 50% greater risk of developing vascular dementia. Moreover, hypertension is also linked to the development of amyloid angiopathy, the progression of white matter lesions (WMLs), and neurodegeneration. This recent meta-analysis demonstrates that higher blood pressure, even within the normal range, is associated with a reduction in global and regional brain volumes.
  • 539
  • 06 Mar 2021
Topic Review
Shift Work Disorder
Shift work disorder (SWD), which is characterized by insomnia and excessive sleepiness related with shift work, is one of the most common health problems in shift workers. Shift work disorder causes insomnia, fatigue, worse work performance, an increased likelihood of accidents, and a poor quality of life. In addition, SWD is associated with decreased productivity and increased economic costs. The correct management of SWD is important to prevent sleep disturbances and maintain work performance in shift workers. To diagnose and evaluate SWD, it is necessary to take detailed medical histories, assess the severity of sleep disturbances, and evaluate shift workers’ sleep using a sleep diary and actigraphy. The work-fitness evaluation should include recommendations on how shift workers can reduce their sleep disturbances and increase work performance, as well as the assessment of work performance. This paper reviews previous research on the evaluation, diagnosis, and management of SWD and summarizes the work-fitness evaluation of SWD.
  • 646
  • 04 Mar 2021
Topic Review
How Paediatric Pain Treatments Work
Clinicians have an increasing number of evidence-based interventions to treat pain in youth. Mediation analysis offers a way of investigating how interventions work, by examining the extent to which an intermediate variable, or mediator, explains the effect of an intervention.
  • 337
  • 03 Mar 2021
Topic Review
Obstructive Sleep Apnea(OSA)
Obstructive sleep apnea (OSA) is a common sleep disorder that affects all age groups and is associated with many co-morbid diseases (especially cardiovascular diseases). Continuous positive airway pressure (CPAP) is the gold standard for treating OSA. However, and with increasing prevalence of CPAP non-adherence, other therapeutic interventions have emerged. Hypoglossal nerve stimulation is a novel modality of treating patients with moderate to severe OSA who are not adherent to CPAP.
  • 401
  • 02 Mar 2021
Topic Review
Transition Care in Rheumatology
The transition from pediatric to adult health care is a challenging yet important process in rheumatology as most childhood-onset rheumatic diseases persist into adulthood. Numerous reports on unmet needs as well as evidence of negative impact from poor transition have led to increased efforts to improve transition care, including international guidelines and recommendations. In line with these recommendations, transition programs along with transition readiness assessment tools have been established. This entry focuses on how transition care in rheumatology has developed in recent years and highlights the gaps in current practices.
  • 522
  • 02 Mar 2021
Topic Review
SARS-CoV-2 Genomics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a great threat to public health, being a causative pathogen of a deadly coronavirus disease (COVID-19). It has spread to more than 200 countries and infected millions of individuals globally. Although SARS-CoV-2 has structural/genomic similarities with the previously reported SARS-CoV and MERS-CoV, the specific mutations in its genome make it a novel virus. Available therapeutic strategies failed to control this virus. Despite strict standard operating procedures (SOPs), SARS-CoV-2 has spread globally and it is mutating gradually as well.
  • 756
  • 02 Mar 2021
Topic Review
Physical Therapy intervene Critically-Ill COVID-19
As part of COVID-19 consequences, it has been estimated that 5% of patients affected by this dis-ease will require admission to the intensive care unit (ICU), and physical therapy techniques have been implemented in patients with other conditions admitted to ICU.
  • 451
  • 02 Mar 2021
Topic Review
COVID-19 Vaccine Hesitancy Worldwide
Utility of vaccine campaigns to control coronavirus 2019 disease (COVID-19) is not merely de-pendent on vaccine efficacy and safety. Vaccine acceptance among the general public and healthcare workers appears to have a decisive role in the successful control of the pandemic.
  • 698
  • 01 Mar 2021
Topic Review
Propolis in Periodontal Disease
Propolis is a natural substance produced by bees which has proven useful for treating periodontal disease. 
  • 701
  • 25 Feb 2021
Topic Review
Pulse Oximetry
Finger pulse oximeters are widely used to monitor physiological responses to high-altitude exposure, the progress of acclimatization, and/or the potential development of high-altitude related diseases. 
  • 622
  • 24 Feb 2021
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