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Topic Review
Intradural Pediatric Spinal Tumors
Pediatric spinal tumors are rare and account for 10% of all central nervous system tumors in children. Onset usually occurs with chronic nonspecific symptoms and may depend on the intra- or extradural neoplastic location. Meningiomas, schwannomas, and neurofibromas are the most common intradural-extramedullary lesions, while astrocytomas and ependymomas represent the majority of intramedullary tumors.
  • 388
  • 08 Oct 2021
Topic Review
Sex and COVID-19 Mortality
Spain is one of the countries most affected by the COVID-19 pandemic. Although risk factors for severe disease are published, sex differences have been widely neglected. In this multicentre study, we aimed to identify predictors of in-hospital mortality in men and women hospitalised with COVID-19. An observational longitudinal study was conducted in the cohort of patients admitted to four hospitals in Andalusia, Spain, from 1 March 2020 to 15 April 2020. Sociodemographic and clinical data were collected from hospital records. The Kaplan-Meier method was used to estimate 30-day survival and multiple Cox regression models were applied. All analyses were stratified by sex. A total of 968 patients were included (54.8% men, median age 67.0 years). In-hospital mortality reached 19.1% in men and 16.0% in women. Factors independently associated with an increased hazard of death were advanced age, higher CURB-65 score and not receiving azithromycin treatment, in both sexes; active cancer and autoimmune disease, in men; cardiovascular disease and chronic lung disease, in women. Disease outcomes and predictors of death differed between sexes. In-hospital mortality was higher in men, but the long-term effects of COVID-19 merit further research. The sex-differential impact of the pandemic should be addressed in public health policies.
  • 542
  • 08 Oct 2021
Topic Review
Remote Assessment in Multiple Sclerosis
The provision and adoption of technological solutions and the sharing of information globally has the potential to drive knowledge acquisition and positively affect healthcare worldwide. Digital solutions offer great promise in delivering increasingly individualised, easily accessible, and effective healthcare, with the capacity to evolve with time and adapt to the changing needs of people living with MS (PLwMS) and health care providers (HCPs). The impact of the COVID-19 pandemic has given additional proof of such versatility and usefulness, highlighting how barriers can be overcome through the adoption of digital tools, where capturing digital data remotely may mean that symptom tracking can be maintained even when clinic visits are not possible.
  • 832
  • 07 Oct 2021
Topic Review
Driver's age and road crash
It has been widely reported that younger and older drivers have an excess risk of causing a road crash. Two casual hypotheses may coexist: the riskier driving behaviors and age-related mechanisms in extreme age groups (direct path) and the different environmental and vehicle circumstances (indirect path). Our aim was to quantify, through a mediation analysis, the percentage contribution of both paths. A case-control study was designed from the Spanish Register of Road Crashes with victims from 2014 to 2017. Assuming a quasi-induced exposure approach, controls were non-responsible drivers involved in clean collisions between two or more vehicles (n = 52,131). Responsible drivers for these collisions plus drivers involved in single crashes constituted the case group (n = 82,071). A logit model in which the outcome was the log (odds) of causing a road crash and the exposure was age groups was adjusted for driver, vehicle and environmental factors. The highest crash risk was observed in extreme age groups, compared to the 35-44 year old age group: the youngest (18-24 years old, odds ratio = 2.14, 95% confidence interval: 2.06-2.24) and the oldest drivers (>74 years old, odds ratio = 3.30, 95% confidence interval: 3.04-2.58). The mediation analysis identified the direct path as the main explanatory mechanism for these increases: 89% in the youngest and 93% in the oldest drivers. These data support the hypothesis that the excess crash risk observed for younger and older drivers is mainly related to their higher frequency of risky driving behaviors and age-related loss of capabilities. Preventive strategies in extreme-aged drivers should focus on decreasing these behaviors.
  • 670
  • 05 Oct 2021
Topic Review
Mediterranean Dietary Patterns During Pregnancy
Pregnancy outcomes for both mother and child are affected by many environmental factors. The importance of pregnancy for ‘early life programming’ in the first 1,000 days of life is well established and maternal nutrition is an important factor contributing to a favourable environment for developing offspring. Results show that being on a Mediterranean Diet during pregnancy is associated with favourable outcomes for both maternal and offspring health, particularly for gestational diabetes in mothers and congenital defects in offspring.
  • 567
  • 30 Sep 2021
Topic Review
Sleep Quantity and Sleep Quality
Sleep is one of the basic physiological processes for human survival. Both sleep quantity and sleep quality are fundamental components of sleep. We should pay more attention to obtaining sleep of good quality (restfulness, no sleepiness, no need for more sleep, sufficient objective sleep depth, etc.), although there have not been enough studies on the associations between sleep quality and health or disorders in children and adolescents.
  • 928
  • 30 Sep 2021
Topic Review
Asynchronous Environment Assessment
The emergence and global spread of COVID-19 has disrupted the traditional mechanisms of education throughout the world. Institutions of learning were caught unprepared and this jeopardised the face-to-face method of curriculum delivery and assessment. Teaching institutions have shifted to an asynchronous mode whilst attempting to preserve the principles of integrity, equity, inclusiveness, fairness, ethics, and safety. A framework of assessment that enables educators to utilise appropriate methods in measuring a student’s progress is crucial for the success of teaching and learning, especially in health education that demands high standards and comprises consistent scientific content. 
  • 1.9K
  • 30 Sep 2021
Topic Review
Artemisia- Antiviral and Immunomodulation Effects
Artemisia is one of the most widely distributed genera of the family Astraceae with more than 500 diverse species growing mainly in the temperate zones of Europe, Asia and North America. The plant is used in Chinese and Ayurvedic systems of medicine for its antiviral, antifungal, antimicrobial, insecticidal, hepatoprotective and neuroprotective properties. Research based studies point to Artemisia’s role in addressing an entire gamut of physiological imbalances through a unique combination of pharmacological actions. Terpenoids, flavonoids, coumarins, caffeoylquinic acids, sterols and acetylenes are some of the major phytochemicals of the genus. Notable among the phytochemicals is artemisinin and its derivatives (ARTs) that represent a new class of recommended drugs due to the emergence of quinoline drug-resistant pathogens.
  • 2.5K
  • 30 Sep 2021
Topic Review
Wearable Devices for Stroke Prediction
Stroke ranks as one of the top first leading causes of death and disability worldwide, particularly for the most populous countries in Asia, Europe, and North America. The emerging wearable devices intended to monitor the physiological parameters, and the growth of machine learning applied to predict diseases, are promising solutions to prevent stroke and eventually predict stroke risk.
  • 8.0K
  • 30 Sep 2021
Topic Review
Vitamin D on Skin Aging
The normal vitamin D3 status is important for a general prevention of premature aging maintaining a healthful skin aging. Vitamin D3metabolites including its classical (1,25(OH)2D3) and novel (CYP11A1-intitated) D3hydroxyderivatives exert many beneficial protective effects on the skin, which could influence the process of premature aging via many different mechanisms, leading to a delay or attenuation of both chronological skin aging and photoaging. Skin-resident cells (keratinocytes, fibroblasts, and sebocytes) are capable of locally activating vitamin D3and exhibiting a diverse biological effect such as photoprotection and immunosuppression, similar to the UVR-induced one.
  • 715
  • 29 Sep 2021
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