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Topic Review
COVID-19 Limitations on Doodling in Measuring Burnout
Burnout is a negative, job-related psychological state exhibited through physical fatigue, emotional exhaustion, and loss of motivation. Pre-COVID-19, doodling was identified as a measure of burnout in researchers attending a weekly, in-person health narratives research group manifesting team mindfulness. Doodling was not retained as a possible measure of burnout during COVID-19 once the weekly health narratives research group moved online and aware attention to present perceptions—one aspect of team mindfulness—was no longer evident.
  • 603
  • 17 Dec 2021
Topic Review
COVID-19, Respiratory Diseases & Drug-Drug Interactions
The absence of COVID-19-targeted treatments has led scientist to exploit available scientific evidence for potential efficient drugs that may block biological pathways of SARS-CoV-2 and several molecules have been emerged as promising pharmacological agents. Then again, due to the criticality of the disease, it is important for healthcare providers in COVID-19 clinics to recognize potential drug-drug interactions (DDIs) that may lead to adverse drug reactions (ADRs) and additional burdens in patients' health status from the administration of these agents.
  • 466
  • 17 Dec 2021
Topic Review
Fluoride Neurotoxicity and Mitochondrial Dysfunction
Current animal and human research suggest that prenatal and perinatal fluoride exposure might have neurotoxic effects. Physical changes associated with fluoride exposure include fur loss and delayed reflex development in animals, intelligence loss, increased hyperactivity, and irregular moods.
  • 754
  • 16 Dec 2021
Topic Review
Colorectal Cancer Screening During the COVID-19 Pandemic
Colonoscopy procedure has been the key screening method to detect colorectal cancer (CRC). As a fatal disease, CRC needs early detection. The COVID-19 (coronavirus disease 2019) pandemic caused screening tests (mainly colonoscopy) to be halted and delayed. At the same time, the use of other screening tests like fecal immunochemical testing (FIT) increased.  
  • 596
  • 15 Dec 2021
Topic Review
Hotspots and Frontiers of Urban Floods
Current research shows that the number of papers published in the field of urban flooding is generally increasing year by year, and the research focus has shifted from exploring hydrological processes to adopting advanced management measures to solve urban flooding problems. 
  • 552
  • 15 Dec 2021
Topic Review
Sleep Dysfunction in COVID-19 Patients
Sleep is an important factor for human well being in order to maintain daily functions, while lack of sleep may lead to an increase in accidents, mood changes, impaired psychological functioning and concentration, and decreased immune response.Sleep problems appear to be rather common in COVID-19 patients and are related to higher levels of psychological distress such as traumatic stress, depression and anxiety and worse coronavirus related outcomes including severity and mortality.Effective programs for the treatment of sleep problems, may lead to the reduction of psychological distress and vice versa and improving the sleep quality of infected patients may improve their outcomes. There is a need for appropriate and tailored management strategies and interventions across different populations including the general public and high risk groups such as Healthcare providers and COVID-19 patients including improved sleep hygiene, identification of various risk factors at individual, interpersonal, institutional and community levels and early and accurate recognition of sleep dysfunction and psychological distress.
  • 494
  • 15 Dec 2021
Topic Review
People Feel about Robot-Assisted Surgery
The goal of the entry was to establish the factors that influence how people feel about having a medical operation performed on them by a robot. 
  • 452
  • 14 Dec 2021
Topic Review
COVID-19 and Migrant/Refugee Health
Against a background where the world has witnessed the largest numbers of migrants in history, the advent of the COVID-19 pandemic has stretched the capacities of countries and of aid, health and relief organizations, from global to local levels, to meet the human rights and pressing needs of migrants and refugees for access to health care and to public health measures needed to protect them from the pandemic. 
  • 396
  • 14 Dec 2021
Topic Review
Therapeutic Response-Related Ferroptosis Regulators in Bladder Cancer
Ferroptosis, an iron-dependent form of regulated cell death characterized by the accumulation of lipid peroxidation, has been reported to regulate tumorigenesis, metastasis, drug resistance and the immune response. However, the potential roles of ferroptosis regulators in the progression of bladder cancer (BLCA) remain unknown. We systematically evaluated the multidimensional alteration landscape of ferroptosis regulators in BLCA and checked if their expression correlated with the ferroptosis index. Using least absolute shrinkage and selection operator (LASSO) regression and multivariate Cox regression, a seven ferroptosis regulator signature was constructed. We validated the prognostic and predictive accuracy of this signature in five independent datasets and established a nomogram to predict the overall survival (OS) and risk of death of BLCA patients. Moreover, the risk score was associated with tumor progression and antitumor immunity-related pathways. Furthermore, the relative antitumor immune cell infiltration level was negatively correlated with the risk score, and the tumor mutation burden was higher in the low-risk group, which might be useful for predicting immunotherapy efficacy. The Tumor Immune Dysfunction and Exclusion (TIDE) database and IMvigor210 cohort with immunotherapy efficacy results were used to confirm the prediction function of the risk score. Furthermore, the ferroptosis regulator signature could also reflect the chemotherapy sensitivity of BLCA. Ferroptosis might play a role in precision individualized chemotherapy and immunotherapy. This entry highlights the crucial clinical implications of ferroptosis and will help with developing personalized therapeutic strategies for BLCA patients
  • 418
  • 13 Dec 2021
Topic Review
SERVQUAL Method as an “Old New” Tool
The SERVQUAL model, which is a research tool, determines the relative impact of five dimensions, namely, tangibility, reliability, responsibility, confidence, and empathy, on customer perception. In the medical field, an efficient identification of errors in the process of creating and providing services is conducive to high quality. The SQ method basically refers to gap 5, the last one in the above list, combining service quality design from the customer’s point of view, where the customer is also the service provider. Service evaluation is carried out by means of a questionnaire/survey, dedicated to this method and regarded as a measurement tool. The Servqual method enables to learn the patient's expectations, while the service provider can identify irregularities and implement corrections. It allows the executive staff of medical facilities to change elements of medical procedures, which improves the quality of the service provided and thus increases satisfaction and compliance of patients.
  • 490
  • 13 Dec 2021
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