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Topic Review
The Process of Plaque Rupture
A warning sign for impending cardiovascular events is not fully established. In the process of plaque rupture, the formation of vulnerable plaque is important, and oxidized cholesterols play an important role in its progression. Furthermore, the significance of vasa vasorum penetrating the medial smooth muscle layer and being rich in atheromatous lesions should be noted. The cardio-ankle vascular index (CAVI) is a new arterial stiffness index of the arterial tree from the origin of the aorta to the ankle. The CAVI reflects functional stiffness, in addition to structural stiffness. The rapid rise in the CAVI means medial smooth muscle cell contraction and strangling vasa vasorum. A rapid rise in the CAVI in people after a big earthquake, following a high frequency of cardiovascular events has been reported. 
  • 128
  • 12 Jan 2024
Topic Review
Performance Factors in Sport Climbing
Key determinants in climbing performance, and thus those present in elite athletes, include improved climbing efficiency, greater ability to apply maximum force or finger and palm pressure resistance, and increased arm locking strength. Additionally, it has been observed that those who can apply higher and more consistent loads experience better muscle oxygenation and have greater flexibility and lateral foot reach. Climbing performance is the result of factors that can be enhanced through training.
  • 221
  • 12 Jan 2024
Topic Review
Teaching Strategies for Nursing Students' Clinical Reasoning Skills
Clinical reasoning (CR) is a holistic cognitive process. It allows nursing students to accurately perceive patients’ situations and choose the best course of action among the available alternatives. This process is consistent, dynamic, and flexible, and it helps nursing students gain awareness and put their learning into perspective.
  • 212
  • 11 Jan 2024
Topic Review
Pediatric Surgery Simulation-Based Training
Pediatric surgery is the diagnostic, operative, and postoperative surgical care of children with congenital and acquired anomalies and diseases. The early history of the specialty followed the classic “see one, do one, teach one” philosophy of training but has since evolved to modern methods including simulation-based training (SBT). Current trainees in pediatric surgery face numerous challenges, such as the decreasing incidence of congenital disease and reduced work hours. 
  • 140
  • 11 Jan 2024
Topic Review
Spectrum of Bisphenols and Phthalates as Endocrine Disruptors
Excess body weight constitutes one of the major health challenges for societies and healthcare systems worldwide. Besides the type of diet, calorie intake and the lack of physical exercise, data have highlighted a possible association between endocrine-disrupting chemicals (EDCs), such as bisphenol A, phthalates and their analogs, and obesity. EDCs represent a heterogeneous group of chemicals that may influence the hormonal regulation of body mass and adipose tissue morphology.
  • 200
  • 10 Jan 2024
Topic Review
Life of Palliative Care Professionals during the COVID-19
The display of compassionate care by palliative care professionals is of the utmost importance to the patients, their families, and even to their own professional well-being. Lately and, especially due to the emergence of the COVID-19 pandemic, palliative care professionals have been subjected to greater pressures stemming from their work environment, organizational standpoint, and emotional sense of view. Not only have these factors made it harder for professionals to deliver compassionate care to their patients, but they have also decreased their overall well-being.
  • 151
  • 09 Jan 2024
Topic Review
Objectivizing Measures of Post-Stroke Hand Rehabilitation through Multi-Disciplinary Scales
There is a wide variety of tools and measures for rehabilitation outcomes in post-stroke patients with impairments in the upper limb and hand, such as paralysis, paresis, flaccidity, and spasticity. However, there is a lack of general recommendations for selecting the most appropriate scales, tests, and instruments to objectively evaluate therapy outcomes. Reviews on upper limb and hand measurements reveal that clinicians’ choices of tools and methods are highly varied. Some clinicians and medical teams continue to employ non-standard and unverified metrics in their research and measurements.
  • 232
  • 09 Jan 2024
Topic Review
Personalization of Therapy in High-Grade Serous Tubo-Ovarian Cancer
High-grade serous tubo-ovarian cancer (HGSTOC) is the most lethal tumor of the female genital tract. The foregoing therapy consists of cytoreduction followed by standard platinum/taxane chemotherapy; alternatively, for primary unresectable tumors, neo-adjuvant platinum/taxane chemotherapy followed by delayed interval cytoreduction. In patients with suboptimal surgery or advanced disease, different forms of targeted therapy have been accepted or tested in clinical trials. Studies on HGSTOC discovered its genetic and proteomic heterogeneity, epigenetic regulation, and the role of the tumor microenvironment. These findings turned attention to the fact that there are several distinct primary tumor subtypes of HGSTOC and the unique biology of primary, metastatic, and recurrent tumors may result in a differential drug response. This results in both chemo-refractoriness of some primary tumors and, what is significantly more frequent and destructive, secondary chemo-resistance of metastatic and recurrent HGSTOC tumors. Treatment possibilities for platinum-resistant disease include several chemotherapeutics with moderate activity and different targeted drugs with difficult tolerable effects. Therefore, the question appears as to why different subtypes of ovarian cancer are predominantly treated based on the same therapeutic schemes and not in an individualized way, adjusted to the biology of a specific tumor subtype and temporal moment of the disease.
  • 130
  • 05 Jan 2024
Topic Review
Unethical Role of Artificial Intelligence in Scholarly Writing
The emergence of artificial intelligence (AI) has greatly propelled progress across various sectors including the field of nephrology academia. However, this advancement has also given rise to ethical challenges, notably in scholarly writing. AI’s capacity to automate labor-intensive tasks like literature reviews and data analysis has created opportunities for unethical practices, with scholars incorporating AI-generated text into their manuscripts, potentially undermining academic integrity. 
  • 356
  • 05 Jan 2024
Topic Review
Sustainable Approaches to Medical Tourism in Greece
Medical tourism involves individuals traveling for health services outside their local environment. Sustainability factors refer to elements or aspects that contribute to the long-term viability and resilience of a system, process, or industry.
  • 327
  • 05 Jan 2024
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