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All Topic Review Biography
Topic Review
Conditions Determining Male Infertility
The lack of knowledge of the causes of impaired reproductive potential results in an inability to implement specific treatment, which is associated with the lack of positive outcomes (pregnancy). This review will make relevant environmental comparisons. It will allow an understanding of the importance of environmental factors in shaping the body's defense and capabilities in the field of reproductive condition. The results can be used in enhancing diagnosis and deciding on appropriate infertility treatment.
  • 712
  • 23 Mar 2021
Topic Review
Critical Limb Ischemia
Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease (PAD), a prevalent manifestation of atherosclerosis which involves the blockade of major systemic arteries other than those of the cerebral and coronary circulation, more common in legs than in arms. Overall, CLI patients suffer from chronic ischemic rest pain, ulcers, or gangrene, as well as an increased risk of cardiovascular events. CLI has a huge impact on the patients’ quality of life, being associated with an increased risk of amputations (fingers, toes, or extremities) and, moreover, an increase in mortality rates. Currently, revascularization strategies (bypass grafting, angioplasty) remain the first option for CLI patients, although less than 45% of them are eligible for surgical intervention mainly due to associated comorbidities. Moreover, patients usually require amputation in the short-term. As an alternative to conventional treatments, therapeutic angiogenesis has arisen as a promising treatment for CLI patients, mainly those considered as “no-option”, due to the potential of this strategy to promote revascularization of ischemic tissues. Different approaches including angiogenic gene or cell-based therapies are currently under investigation.
  • 712
  • 22 Sep 2021
Topic Review
Organizational Health Literacy
The term organizational health literacy (OHL) is a new concept that emerged to address the challenge of predominantly in patients with limited health literacy (HL). 
  • 709
  • 09 Feb 2021
Topic Review
Aging of BM-MSCs
Aging of bone marrow is a complex process that is involved in the development of many diseases, including hematologic cancers. The results obtained in this field of research, year after year, underline the important role of cross-talk between hematopoietic stem cells and their close environment. In bone marrow, mesenchymal stromal cells (MSCs) are a major player in cell-to-cell communication, presenting a wide range of functionalities, sometimes opposite, depending on the environmental conditions. Although these cells are actively studied for their therapeutic properties, their role in tumor progression remains unclear. One of the reasons for this is that the aging of MSCs has a direct impact on their behavior and on hematopoiesis. In addition, tumor progression is accompanied by dynamic remodeling of the bone marrow niche that may interfere with MSC functions.
  • 699
  • 06 May 2021
Topic Review
Last Four Decades' Viral Pandemics
The last four decades have witnessed some of the deadliest viral pandemics with far-reaching consequences. These include the Human Immunodeficiency Virus (HIV) (1981), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) (2002), Influenza A virus subtype H1N1 (A/H1N1) (2009), Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (2012), Ebola virus (2013) and the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) (2019-present). Age- and gender-based characterizations suggest that SARS-CoV-2 resembles SARS-CoV and MERS-CoV with regard to higher fatality rates in males, and in the older population with comorbidities. The invasion-mechanism of SARS-CoV-2 and SARS-CoV, involves binding of its spike protein with angiotensin-converting enzyme 2 (ACE2) receptors; MERS-CoV utilizes dipeptidyl peptidase 4 (DPP4), whereas H1N1 influenza is equipped with hemagglutinin protein.
  • 701
  • 08 Jan 2021
Topic Review
Mindfulness-Based Interventions for Undergraduate Nursing Students
Undergraduate (UG) nursing students are vulnerable to stress throughout their education, known to result in burnout, with high attrition rates of up to 33%. There is a growing body of evidence to suggest that mindfulness-based interventions are effective for the management of anxiety, depression and wellbeing, thereby reducing stress in healthcare provider populations. 
  • 664
  • 18 Nov 2021
Topic Review
Adults with Metabolic Syndrome
Metabolic syndrome (MetS), a cluster of abdominal obesity, hyperglycemia, hypertriglyceridemia, low HDL (high density lipoprotein)-cholesterol, and hypertension, is known to be a strong risk factor for type 2 diabetes and is considered one of the most important preventable risk factors for cardiovascular diseases, whose prevalence is increasing.
  • 664
  • 14 Apr 2021
Topic Review
CBD treatment during Covid-19 Pandemic
At the end of 2019, a new disease —COVID-19—was identified, and a few months later, the World Health Organization announced a pandemic. It is now known that SARS-CoV-2 is highly contagious and most confirmed infections are mild to moderate. The situation is particularly difficult for dentists due to the high risk of virus transmission in the dental surgery. Complications including, but not limited to, problems with the respiratory and cardiovascular systems have been reported in patients with SARS-CoV-2. Several changes in the coagulation system, such as lower platelet numbers or increased prothrombin time, as well as increased D-dimer and fibrinogen, were observed. This review is intended to systematize the knowledge on the treatment of patients with congenital bleeding disorders (CBD) during the SARS-CoV-2 pandemic. Extensive literature research was conducted into COVID-19 and the general medical and dental treatment of patients with CBD. Case studies, research results and recommendations of international societies were used in the study. The results of this research are presented in the form of recommendations for the treatment of patients with coagulopathies. It should be remembered that the impact of COVID-19 on the health condition of patients with CBD is unknown to date.
  • 656
  • 14 Oct 2020
Topic Review
First Ray Mobility
Several methods have been described to quantify the first ray mobility. They have certain disadvantages (great size, sophistication, or lack of validation). The objective of this work was to study the validity and reliability of a new instrument for the measurement of first ray mobility. This new device has characteristics that make it possible to be used in daily clinical practice, such as simplicity, lightness, small size and ease of use. The results obtained suggest that the new instrument is valid and reliable.
  • 647
  • 23 Apr 2021
Topic Review
Sexuality and Mental Health in Heterosexual Adolescents
During puberty and emerging sexuality, adolescents experience important physical, mental, and social transformations. In the process of dealing with these changes, adolescents can become potentially vulnerable to mental health problems. 
  • 646
  • 22 Apr 2022
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