Topic Review
Full Value of Vaccine Assessment
A framework to guide the assessment and communication of the value of a vaccine—the Full Value of Vaccine Assessment (FVVA)—has been developed by the WHO. The FVVA framework offers a holistic assessment of the value of vaccines, providing a synthesis of evidence to inform the public health need of a vaccine, describing the supply and demand aspects, its market and its impact from a health, financial and economic perspective. 
  • 42
  • 08 Mar 2024
Topic Review
Just and Fair ICU Triage Process
Triage is a dynamic and complex decision-making process to determine fair access to medical care in mass casualty situations. Triage takes place through healthcare settings including Intensive Care Units (ICUs). Triage governing principles have been subject to ethical debates for a long time specifically with the recent global pandemic of COVID-19. 
  • 80
  • 01 Mar 2024
Topic Review
Lung Cancer Incidence and Socioeconomic Status
Lung cancer treatment and patient care continue to advance, yet concerns persist about whether these improvements are equally accessible to all socioeconomic groups. Socioeconomic disparities exist in lung cancer incidence, screening, effective treatment, overall survival, and prognosis. One of the key contributing factors to low socioeconomic status that is amenable to change is low education. Lower educational attainment is oftentimes linked to various factors, including smoking habits, unhealthy lifestyle behaviors, lower paid and unhealthier occupations, exposure to environmental pollutants, and genetic-familial risks, all contributing to an elevated incidence of lung cancer.
  • 140
  • 29 Feb 2024
Topic Review
System Structure of Appointment Scheduling
In the face of an increasingly high-demand environment for outpatients, achieving a balance between allocation of limited medical resources and patient satisfaction has considerable social and economic benefits. Therefore, appointment scheduling (AS) system operation is used in clinics and hospitals, and its operation optimization research is of great significance.
  • 141
  • 23 Feb 2024
Topic Review
Revolutionizing HIV-1 Viral Load Monitoring in India
India continues to grapple with a significant burden of HIV infections. Despite notable progress in prevention and treatment efforts, multiple challenges, such as high-risk populations, inadequate testing facilities, and limited access to healthcare in remote areas, persist. Though the Government of India offers HIV-1 plasma viral load testing at various medical centers, aiding treatment decisions and monitoring antiretroviral therapy effectiveness, enhancing care for individuals living with HIV under the National AIDS Control Program (NACP), the nation’s large population and diverse demographics further complicate its outreach and response. Hence, strategic interventions and alternative methods of testing remain crucial to curbing HIV transmission and improving the quality of life for those affected. Dried blood spot (DBS) sampling has emerged as a convenient and cost-effective alternative for HIV-1 viral load testing, revolutionizing the landscape of diagnostic and monitoring strategies for HIV infection. Though the plasma-based viral load remains the gold standard for monitoring HIV-1, DBS-based HIV-1 viral load testing holds immense promise for improving access to care, particularly in resource-limited settings where traditional plasma-based methods may be logistically challenging. DBS entails the collection of a small volume of blood onto filter paper, followed by drying and storage. This approach offers numerous advantages, including simplified sample collection, transportation, and storage, reducing the need for cold-chain logistics. 
  • 57
  • 18 Feb 2024
Topic Review
Promoting Better Mental Health in People with Autism
The rising prevalence of autism internationally has been accompanied by an increased appreciation of the poorer mental health experienced by people with this condition and also of their family care-givers. In particular, higher incidences of anxiety and depression are reported in high-income nations and these conditions are likely to be under-recognised and under-reported in lower-resourced regions or countries. Mainstream mental health services seem to be ill-equipped to respond adequately to the needs of autistic persons and their care-givers.
  • 69
  • 07 Feb 2024
Topic Review
Caring for Migrant Populations in Italy
The foreign population living in Italy, on 1 January 2021, was about 5.2 million, plus about 500,000 irregular foreigners, according to the ISMU Foundation. It is a “young” population, with a high rate of unaccompanied foreign minors, and the male: female ratio is about 1:1, with wide differences depending on the citizenship of origin.
  • 84
  • 06 Feb 2024
Topic Review
Potential Harmful Effects of Genetically Engineered Microorganisms
Gut luminal dysbiosis and pathobiosis result in compositional and biodiversified alterations in the microbial and host co-metabolites. The primary mechanism of bacterial evolution is horizontal gene transfer (HGT), and the acquisition of new traits can be achieved through the exchange of mobile genetic elements (MGEs). Introducing genetically engineered microbes (GEMs) might break the harmonized balance in the intestinal compartment.
  • 49
  • 31 Jan 2024
Topic Review
Clinical Management of Multidrug-Resistant Sepsis
Sepsis is a critical medical condition associated with significant biological and chemical abnormalities that pose a high death rate. Unlike superficial and confined infections, sepsis is a complex disturbance of the delicate immunologic equilibrium between inflammatory and anti-inflammatory responses. This interaction demonstrates the fragile connection between the immune system and the clinical signs of sepsis. Sepsis globally accounts for an alarming annual toll of 48.9 million cases, resulting in 11 million deaths, and inflicts an economic burden of approximately USD 38 billion on the United States healthcare system. The rise of multidrug-resistant organisms (MDROs) has elevated the urgency surrounding the management of multidrug-resistant (MDR) sepsis, evolving into a critical global health concern.
  • 108
  • 18 Jan 2024
Topic Review
Disparities in Breast Cancer Diagnostics
Access to medical imaging is pivotal in healthcare, playing a crucial role in the prevention, diagnosis, and management of diseases. However, disparities persist in this scenario, disproportionately affecting marginalized communities, racial and ethnic minorities, and individuals facing linguistic or cultural barriers.
  • 117
  • 03 Jan 2024
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