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Topic Review
The Tryptophan-Kynurenine Metabolic Pathway
Tryptophan (TRP) is one of the essential amino acids, which participates in protein synthesis. The tryptophan’s main metabolic route is the kynurenine pathway (KP) through which approximately 90-95% of TRP degrades into nicotinamide adenine dinucleotide (NAD+) and other bioactive metabolites. The appropriate amount of NAD+ is essential to maintain the operation and the viability of cells. The other molecules are neurotoxic, neuroprotective, oxidant, antioxidant, and/or immune modifiers. They play an important role in the function of the brain and the peripheral tissues. The change in the levels of the bioactive molecules is considered to contribute to the development of a wide range of illnesses from cancer to immunologic, neurodegenerative, and psychiatric diseases.
  • 10.8K
  • 10 Aug 2021
Topic Review
Death Anxiety
Death anxiety is an unavoidable common phenomenon in our lives across cultures and religions. It is multidimensional and explained by different theoretical frameworks. Death anxiety can have negative impacts on wellbeing. Death is an inevitable experience that generates a reduced sense of safety and stronger fear (Alkozei et al. 2019). 
  • 6.2K
  • 06 Feb 2021
Topic Review
CBT-E for Eating Disorders
Enhanced cognitive behaviour therapy, also known as CBT-E, is a “transdiagnostic” psychological treatment for all forms of eating disorder including anorexia nervosa, bulimia nervosa, binge eating disorder and other similar states. CBT-E is the only treatment recommended by the National Institute for Health and Care Excellence (NICE) for all the forms of eating disorders both for adults and adolescents
  • 2.0K
  • 27 Oct 2020
Topic Review Peer Reviewed
Homeopathy and Psychological Therapies
Homeopathy is a popular, although highly debated, medicinal practice based on the administration of remedies in which active substances are so diluted that no detectable trace of them remains in the final product. This hypothesis paper aims to outline a possible reinterpretation of homeopathy in the light of psychological therapies in order to improve its clinical safety and sustainability. 
  • 1.6K
  • 13 Apr 2022
Topic Review
Internet Addiction Disorder
Internet addiction disorder (IAD), sometimes also called pathologic/problematic internet use (PIU), is widely defined in terms of an impulse control disorder characterized by uncontrolled Internet use. The disorder is associated with significant functional impairment and/or clinically measurable distress, anxiety, depression, and other psychopathological symptom.
  • 1.6K
  • 30 Oct 2020
Topic Review
Effects of Stress Exposure
Stress could be defined as an organism's entire response to environmental demands or strains. Exposure to highly stressful or traumatic events, depending on the stage of life in which stress exposure occurs, could severely affect limbic structures, including the amygdala, and lead to alterations in social and affective behaviors.
  • 1.6K
  • 30 Jan 2021
Topic Review
European Policy Preventing Internet Addiction
Internet use-related addiction problems are increasingly being recognized on a European scale due to international health organizations considering gaming addiction. In April 2013, the American Psychiatric Association recognized Internet Gaming Disorder in the fifth Diagnostic and Statistical Manual of Mental Disorders, and in April 2018, the World Health Organization included Gaming Disorder in the eleventh International Classification of Diseases. However, findings on these problems within this period are lacking in Europe, and a preventive approach is missing globally. A detailed critical literature review was conducted using PsycINFO and Web of Science in this five-year period. A total of 19 studies were reviewed and problems identified were: generalized Internet addiction and online gaming and gambling addictions across seven European countries (i.e., Spain, Germany, France, Italy, Greece, The Netherlands, and Denmark). The individuals with problematic use were found to be educated adolescents, usually young males with comorbid disorders, and gaming and gambling disorders were implicated in the most severe cases. Cognitive behavioral therapy was the main treatment, sometimes combined with a systemic approach for adolescents. Prevalence, high-risk populations, and factors contributing to these addiction problems are discussed, and a set of policy options are developed for this region. The implications for early detection, diagnosis, treatment, and prevention in Europe are considered.
  • 1.5K
  • 06 Nov 2020
Topic Review
Voyeurism
Voyeurism is the sexual interest in or practice of watching other people engaged in intimate behaviors, such as undressing, sexual activity, or other actions usually considered to be of a private nature. The term comes from the French voir which means "to see". A male voyeur is commonly labelled as "Peeping Tom" or a "Jags", a term which originates from the Lady Godiva legend. However, that term is usually applied to a male who observes somebody secretly and, generally, not in a public space. The American Psychiatric Association has classified certain voyeuristic fantasies, urges and behaviour patterns as a paraphilia in the Diagnostic and Statistical Manual (DSM-IV) if the person has acted on these urges, or the sexual urges or fantasies cause marked distress or interpersonal difficulty. It is described as a disorder of sexual preference in the ICD-10. The DSM-IV defines voyeurism as the act of looking at "unsuspecting individuals, usually strangers, who are naked, in the process of disrobing, or engaging in sexual activity". The diagnosis would not be given to people who experience typical sexual arousal simply by seeing nudity or sexual activity. In order to be diagnosed with voyeuristic disorder the symptoms must persist for over six months and the person in question must be over the age of 18.
  • 1.3K
  • 11 Nov 2022
Topic Review
Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder characterized by the impairment of the cognitive function of a child. Studies suggested that the intestinal microbiota has a critical role in the function and regulation of the central nervous system, neuroimmune system, and neuroendocrine system. Any adverse changes in the gut-brain axis may cause serious diseases. Food preferences and dietary patterns are considered as key influencing factors of ASD development. Several recent reviews narrated the importance of dietary composition on controlling or reducing the ASD symptoms. It has been known that consumption of probiotics confers several health benefits by positive amendment of gut microbiota. Influence of probiotic intervention in children with ASD have also been reported and it has been considered as an alternative and complementary therapeutic supplement for ASD. The present manuscript discussed the role of microbiota in the development of ASD. 
  • 1.3K
  • 28 Oct 2020
Topic Review
Paraphilia
Paraphilia (previously known as sexual perversion and sexual deviation) is the experience of intense sexual arousal to atypical objects, situations, fantasies, behaviors, or individuals. There is no scientific consensus for any precise border between unusual sexual interests and paraphilic ones. There is debate over which, if any, of the paraphilias should be listed in diagnostic manuals, such as the Diagnostic and Statistical Manual of Mental Disorders (DSM) or the International Classification of Diseases (ICD). The number and taxonomy of paraphilia is under debate; one source lists as many as 549 types of paraphilia. The DSM-5 has specific listings for eight paraphilic disorders. Several sub-classifications of the paraphilias have been proposed, and some argue that a fully dimensional, spectrum or complaint-oriented approach would better reflect the evidence.
  • 1.3K
  • 29 Nov 2022
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