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Topic Review
Triple-Alpha Process
The triple-alpha process is a set of nuclear fusion reactions by which three helium-4 nuclei (alpha particles) are transformed into carbon.
  • 1.8K
  • 22 Nov 2022
Topic Review
Ionizing Radiation
The development of protective agents against harmful radiations has been a subject of investigation for decades. However, effective (ideal) radioprotectors and radiomitigators remain an unsolved problem. Because ionizing radiation-induced cellular damage is primarily attributed to free radicals, radical scavengers are promising as potential radioprotectors. Early development of such agents focused on thiol synthetic compounds, e.g., amifostine (2-(3-aminopropylamino) ethylsulfanylphosphonic acid), approved as a radioprotector by the Food and Drug Administration (FDA, USA) but for limited clinical indications and not for nonclinical uses. To date, no new chemical entity has been approved by the FDA as a radiation countermeasure for acute radiation syndrome (ARS). All FDA-approved radiation countermeasures (filgrastim, a recombinant DNA form of the naturally occurring granulocyte colony-stimulating factor, G-CSF; pegfilgrastim, a PEGylated form of the recombinant human G-CSF; sargramostim, a recombinant granulocyte macrophage colony-stimulating factor, GM-CSF) are classified as radiomitigators. No radioprotector that can be administered prior to exposure has been approved for ARS. This differentiates radioprotectors (reduce direct damage caused by radiation) and radiomitigators (minimize toxicity even after radiation has been delivered). Molecules under development with the aim of reaching clinical practice and other nonclinical applications are discussed. Assays to evaluate the biological effects of ionizing radiations are also analyzed. Ionizing radiation is the energy released by atoms in the form of electromagnetic waves (e.g., X or gamma rays) or particle radiation (alpha, beta, electrons, protons, neutrons, mesons, prions, and heavy ions) with sufficient energy to ionize atoms or molecules.
  • 1.7K
  • 23 Feb 2022
Topic Review
Position and Momentum Space
In physics and geometry, there are two closely related vector spaces, usually three-dimensional but in general could be any finite number of dimensions. Position space (also real space or coordinate space) is the set of all position vectors r in space, and has dimensions of length. A position vector defines a point in space. If the position vector of a point particle varies with time it will trace out a path, the trajectory of a particle. Momentum space is the set of all momentum vectors p a physical system can have. The momentum vector of a particle corresponds to its motion, with units of [mass][length][time]−1. Mathematically, the duality between position and momentum is an example of Pontryagin duality. In particular, if a function is given in position space, f(r), then its Fourier transform obtains the function in momentum space, φ(p). Conversely, the inverse Fourier transform of a momentum space function is a position space function. These quantities and ideas transcend all of classical and quantum physics, and a physical system can be described using either the positions of the constituent particles, or their momenta, both formulations equivalently provide the same information about the system in consideration. Another quantity is useful to define in the context of waves. The wave vector k (or simply "k-vector") has dimensions of reciprocal length, making it an analogue of angular frequency ω which has dimensions of reciprocal time. The set of all wave vectors is k-space. Usually r is more intuitive and simpler than k, though the converse can also be true, such as in solid-state physics. Quantum mechanics provides two fundamental examples of the duality between position and momentum, the Heisenberg uncertainty principle ΔxΔp ≥ ħ/2 stating that position and momentum cannot be simultaneously known to arbitrary precision, and the de Broglie relation p = ħk which states the momentum and wavevector of a free particle are proportional to each other. In this context, when it is unambiguous, the terms "momentum" and "wavevector" are used interchangeably. However, the de Broglie relation is not true in a crystal.
  • 1.7K
  • 24 Nov 2022
Topic Review
Photon
A photon (from grc φῶς, φωτός  'light') is an elementary particle that is a quantum of the electromagnetic field, including electromagnetic radiation such as light and radio waves, and the force carrier for the electromagnetic force. Photons are massless,[lower-alpha 1] so they always move at the speed of light in vacuum, 299792458 m/s (or about 186,282 mi/s). The photon belongs to the class of bosons. Like all elementary particles, photons are currently best explained by quantum mechanics, and exhibit wave–particle duality, their behavior featuring properties of both waves and particles. The modern photon concept originated during the first two decades of the 20th century with the work of Albert Einstein, who built upon the research of Max Planck. While trying to explain how matter and electromagnetic radiation could be in thermal equilibrium with one another, Planck proposed that the energy stored within a material object should be regarded as composed of an integer number of discrete, equal-sized parts. To explain the photoelectric effect, Einstein introduced the idea that light itself is made of discrete units of energy. In 1926, Gilbert N. Lewis popularized the term photon for these energy units. Subsequently, many other experiments validated Einstein's approach. In the Standard Model of particle physics, photons and other elementary particles are described as a necessary consequence of physical laws having a certain symmetry at every point in spacetime. The intrinsic properties of particles, such as charge, mass, and spin, are determined by gauge symmetry. The photon concept has led to momentous advances in experimental and theoretical physics, including lasers, Bose–Einstein condensation, quantum field theory, and the probabilistic interpretation of quantum mechanics. It has been applied to photochemistry, high-resolution microscopy, and measurements of molecular distances. Moreover, photons have been studied as elements of quantum computers, and for applications in optical imaging and optical communication such as quantum cryptography.
  • 1.7K
  • 23 Oct 2022
Topic Review
Kikuchi Lines
Kikuchi lines are patterns of electrons formed by scattering. They pair up to form bands in electron diffraction from single crystal specimens, there to serve as "roads in orientation-space" for microscopists uncertain of what they are looking at. In transmission electron microscopes, they are easily seen in diffraction from regions of the specimen thick enough for multiple scattering. Unlike diffraction spots, which blink on and off as one tilts the crystal, Kikuchi bands mark orientation space with well-defined intersections (called zones or poles) as well as paths connecting one intersection to the next. Experimental and theoretical maps of Kikuchi band geometry, as well as their direct-space analogs e.g. bend contours, electron channeling patterns, and fringe visibility maps are increasingly useful tools in electron microscopy of crystalline and nanocrystalline materials. Because each Kikuchi line is associated with Bragg diffraction from one side of a single set of lattice planes, these lines can be labeled with the same Miller or reciprocal-lattice indices that are used to identify individual diffraction spots. Kikuchi band intersections, or zones, on the other hand are indexed with direct-lattice indices i.e. indices which represent integer multiples of the lattice basis vectors a, b and c. Kikuchi lines are formed in diffraction patterns by diffusely scattered electrons, e.g. as a result of thermal atom vibrations. The main features of their geometry can be deduced from a simple elastic mechanism proposed in 1928 by Seishi Kikuchi, although the dynamical theory of diffuse inelastic scattering is needed to understand them quantitatively. In x-ray scattering, these lines are referred to as Kossel lines (named after Walther Kossel).
  • 1.6K
  • 09 Nov 2022
Topic Review
CNO Cycle
The CNO cycle (for carbon–nitrogen–oxygen; sometimes called Bethe–Weizsäcker cycle after Hans Albrecht Bethe and Carl Friedrich von Weizsäcker) is one of the two known sets of fusion reactions by which stars convert hydrogen to helium, the other being the proton–proton chain reaction (p-p cycle), which is more efficient at the Sun's core temperature. The CNO cycle is hypothesized to be dominant in stars that are more than 1.3 times as massive as the Sun. Unlike the proton-proton reaction, which consumes all its constituents, the CNO cycle is a catalytic cycle. In the CNO cycle, four protons fuse, using carbon, nitrogen, and oxygen isotopes as catalysts, each of which is consumed at one step of the CNO cycle, but re-generated in a later step. The end product is one alpha particle (a stable helium nucleus), two positrons, and two electron neutrinos. There are various alternative paths and catalysts involved in the CNO cycles, all these cycles have the same net result: The positrons will almost instantly annihilate with electrons, releasing energy in the form of gamma rays. The neutrinos escape from the star carrying away some energy. One nucleus goes on to become carbon, nitrogen, and oxygen isotopes through a number of transformations in an endless loop. The proton–proton chain is more prominent in stars the mass of the Sun or less. This difference stems from temperature dependency differences between the two reactions; pp-chain reaction starts at temperatures around 4×106 K (4 megakelvin), making it the dominant energy source in smaller stars. A self-maintaining CNO chain starts at approximately 15×106 K, but its energy output rises much more rapidly with increasing temperatures so that it becomes the dominant source of energy at approximately 17×106 K. The Sun has a core temperature of around 15.7×106 K, and only 1.7% of 4He nuclei produced in the Sun are born in the CNO cycle. The CNO-I process was independently proposed by Carl von Weizsäcker and Hans Bethe in the late 1930s. The first reports of the experimental detection of the neutrinos produced by the CNO cycle in the Sun were published in 2020. This was also the first experimental confirmation that the Sun had a CNO cycle, that the proposed magnitude of the cycle was accurate, and that von Weizsäcker and Bethe were correct.
  • 1.6K
  • 03 Nov 2022
Topic Review
FFAG Accelerator
A Fixed-Field Alternating Gradient accelerator (FFAG) is a circular particle accelerator concept on which development was started in the early 50s, and that can be characterized by its time-independent magnetic fields (fixed-field, like in a cyclotron) and the use of strong focusing (alternating gradient, like in a synchrotron). Thus, FFAG accelerators combine the cyclotron's advantage of continuous, unpulsed operation, with the synchrotron's relatively inexpensive small magnet ring, of narrow bore. Although the development of FFAGs had not been pursued for over a decade starting from 1967, it has regained interest since the mid-1980s for usage in neutron spallation sources, as a driver for muon colliders and to accelerate muons in a neutrino factory since the mid-1990s. The revival in FFAG research has been particularly strong in Japan with the construction of several rings. This resurgence has been prompted in part by advances in RF cavities and in magnet design.
  • 1.3K
  • 01 Nov 2022
Topic Review
Radiative Transfer Equation and Diffusion Theory for Photon Transport in Biological Tissue
The RTE can mathematically model the transfer of energy as photons move inside a tissue. The flow of radiation energy through a small area element in the radiation field can be characterized by radiance [math]\displaystyle{ L(\vec{r},\hat{s},t) (\frac{W}{m^2 sr}) }[/math]. Radiance is defined as energy flow per unit normal area per unit solid angle per unit time. Here, [math]\displaystyle{ \vec{r} }[/math] denotes position, [math]\displaystyle{ \hat{s} }[/math] denotes unit direction vector and [math]\displaystyle{ t }[/math] denotes time. 
  • 1.2K
  • 16 Nov 2022
Topic Review
J/Psi Meson
The J/ψ (J/psi) meson /ˈdʒeɪ ˈsaɪ ˈmiːzɒn/ or psion is a subatomic particle, a flavor-neutral meson consisting of a charm quark and a charm antiquark. Mesons formed by a bound state of a charm quark and a charm anti-quark are generally known as "charmonium". The J/ψ is the most common form of charmonium, due to its spin of 1 and its low rest mass. The J/ψ has a rest mass of 3.0969 GeV/c2, just above that of the ηc (2.9836 GeV/c2), and a mean lifetime of 7.2×10−21 s. This lifetime was about a thousand times longer than expected. Its discovery was made independently by two research groups, one at the Stanford Linear Accelerator Center, headed by Burton Richter, and one at the Brookhaven National Laboratory, headed by Samuel Ting of MIT. They discovered they had actually found the same particle, and both announced their discoveries on 11 November 1974. The importance of this discovery is highlighted by the fact that the subsequent, rapid changes in high-energy physics at the time have become collectively known as the "November Revolution". Richter and Ting were awarded the 1976 Nobel Prize in Physics.
  • 1.0K
  • 09 Nov 2022
Topic Review
4D Scanning Transmission Electron Microscopy
4D scanning transmission electron microscopy (4D STEM) is a subset of scanning transmission electron microscopy (STEM) which utilizes a pixelated electron detector to capture a convergent beam electron diffraction (CBED) pattern at each scan location. This technique captures a 2 dimensional reciprocal space image associated with each scan point as the beam rasters across a 2 dimensional region in real space, hence the name 4D STEM. Its development was enabled by evolution in STEM detectors and improvements computational power. The technique has applications in visual diffraction imaging, phase orientation and strain mapping, phase contrast analysis, among others. The name 4D STEM is common in literature, however it is known by other names: 4D STEM EELS, ND STEM (N- since the number of dimensions could be higher than 4), position resolved diffraction (PRD), spatial resolved diffractometry, momentum-resolved STEM, "nanobeam precision electron diffraction", scanning electron nano diffraction, nanobeam electron diffraction, or pixelated STEM.
  • 995
  • 11 Oct 2022
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