Topic Review
Theranostic Radiopharmaceuticals
Theranostic Radiopharmaceuticals (Radiotheranostics) is a term in the medical field to define the combination of therapeutic and diagnostic techniques by a suitable radiopharmaceutical agent. Radionuclides are isotopes that emit radiation or have excess nuclear energy, making them chemically unstable and tend to change into another atom. Various types of radiation can be emitted by radionuclides e.g. alpha particles, beta particles, and gamma energy. In radiotheranostics, a pharmaceutical agent (drug) is needed to be a carrier molecule that introduces the radionuclide to its target. Radionuclides are then used as a source of radiation in radiotheranostics that are responsible for diagnosing or treating various diseases.
  • 1.3K
  • 24 May 2022
Topic Review
Posteromedial Lesions of the Chest Wall
A heterogeneous group of tumors can affect the posteromedial chest wall. They form diverse groups of benign and malignant (primary or secondary) pathologies that can arise from different chest wall structures, i.e., fat, muscular, vascular, osseous, or neurogenic tissues. Chest radiography is very nonspecific for the characterization of chest wall lesions. The modality of choice for the initial assessment of the chest wall lesions is computed tomography (CT). More advanced cross-sectional modalities such as magnetic resonance imaging (MRI) and positron emission tomography (PET) with fluorodeoxyglucose are usually used for further characterization, staging, treatment response, and assessment of recurrence. A systematic approach based on age, clinical history, and radiologic findings is required for correct diagnosis. It is essential for radiologists to be familiar with the spectrum of lesions that might affect the posteromedial chest wall and their characteristic imaging features. Although the imaging findings of these tumors can be nonspecific, cross-sectional imaging helps to limit the differential diagnosis and determine the further diagnostic investigation (e.g., image-guided biopsy). Specific imaging findings, e.g., location, mineralization, enhancement pattern, and local invasion, occasionally allow a particular diagnosis.
  • 989
  • 16 Feb 2022
Topic Review
MRS in Hepatic Fat
Magnetic resonance spectroscopy (MRS) is a powerful tool that allows direct quantification of metabolites in tissue or areas of interest. MRS has been applied in both research and clinical studies to assess liver fat noninvasively in vivo. MRS has also demonstrated excellent performance in liver fat assessment with high sensitivity and specificity compared to biopsy and other imaging modalities. Because of these qualities, MRS has been generally accepted as the reference standard for the noninvasive measurement of liver steatosis. MRS is an evolving technique with high potential as a diagnostic tool in the clinical setting. 
  • 905
  • 12 Oct 2021
Topic Review
Renal Artery Ultrasound
Renal artery stenosis (RAS) is one of the major causes of secondary hypertension and renal impairment. Ultrasound (US) is a noninvasive, real-time examination method for detecting RAS. The available US scanners enable the depiction of small vessels or organs. Gray-scale US can assess the morphology of the renal artery and kidney. Hemodynamic changes in the renal artery and kidney are evaluated with color and spectral Doppler US. Contrast-enhanced US may directly show the diameter change in the renal artery with intravascular contrast material that is not harmful to patients with poor renal function. Therefore, US is a useful examination method for detecting RAS, regardless of patient renal function. 
  • 878
  • 14 Oct 2022
Topic Review
Imaging Findings of Lung Nodule or Mass
Systemic endemic mycoses are a group of dimorphic fungi prevalent in specific geographical locations. Histoplasma capsulatum, Coccidioides spp., Blastomyces dermatitidis, Cryptococcosis gattii, and Paracoccidioides brasiliensis are the primary pulmonary fungal pathogens of otherwise healthy people. Acute or chronic fungal infections may manifest as solitary or multiple lung nodules or masses. The most frequent pathogens are histoplasmosis, coccidioidomycosis, cryptococcosis, and blastomycosis. The nodules have a nonspecific appearance, may be ill or well-defined, have regular or spiculated borders, and may also demonstrate cavitation or ground glass halo.
  • 879
  • 04 Nov 2022
Topic Review
HRCT of Drug-Induced ILD
Interstitial Lung Diseases (ILDs) represent a heterogeneous group of pathologies, which may be related to different causes. A low percentage of these lung diseases may be secondary to the administration of drugs or substances. Several different high resolution computed tomography (HRCT) patterns related to pulmonary drug toxicity have been reported in literature, and the most frequent ILDs patterns reported include Nonspecific Interstitial Pneumonia (NSIP), Usual Interstitial Pneumonia (UIP), Hypersensitivity Pneumonitis (HP), Organizing Pneumonia (OP), Acute Respiratory Distress Syndrome (ARDS), and Diffuse Alveolar Damage (DAD). 
  • 830
  • 14 Jul 2021
Topic Review
Magnetic Resonance Imaging for Sjögren’s Syndrome
Primary Sjögren’s Syndrome (pSS) is a chronic autoimmune exocrinopathy affecting 0.3–3.0% of the population. Its main clinical hallmarks are the sicca symptoms (mucosal dryness manifesting mainly ocularly and orally) and extra-glandular symptoms, among which joint pain and chronic fatigue are the most important. Besides these symptoms, pSS may also manifest in the central nervous system (CNS), as noted in the original description of the disease by Sjögren himself in 1933. The most common radiological lesions in pSS are white matter hyperintensities (WMH), scattered alterations hyperlucent on T2 and FLAIR sequences, typically located periventricularly and subcortically. Cortical atrophy and ventricular dilatation can also occur in pSS. Whilst these conditions are thought to be more common in pSS than healthy controls, diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI) alterations demonstrate evident microstructural changes in pSS. As pSS is often accompanied by cognitive symptoms, these magnetic resonance imaging (MRI) alterations are expectedly related to them. 
  • 808
  • 31 Jan 2023
Topic Review
COVID-19 Pneumonia and Lung Cancer
Oncological patients are more prone to present severe forms of COVID-19 pneumonia and are subject to worse complications. Radiologists have the challenging role of suggesting a differential diagnosis with lung cancer and treatment-induced lung diseases or suggesting an overlap between these pathologies. Despite similarities or overlapping findings, the combination of clinics and some specific radiological findings, which are also identified by comparison with previous and follow-up CT scans, may guide differential diagnosis.
  • 807
  • 01 Apr 2022
Topic Review
Advantages and Applications of Total-Body PET Scanning
Total-body positron emission tomography (PET)  scanning can not only image faster than traditional techniques with less administered radioactivity but also perform total-body dynamic acquisition at a longer delayed time point based on its ultrahigh detection sensitivity, enhanced temporal resolution, and long scan range (194 cm). These unique characteristics create several opportunities to improve image quality and can provide a deeper understanding regarding disease detection, diagnosis, staging/restaging, response to treatment, and prognostication. 
  • 799
  • 21 Feb 2022
Topic Review
Pulsed Laser Ablation in Liquid for Gold Nanoparticle
The unique physiochemical properties and biocompatibility of gold nanoparticles have developed a breakthrough in molecular imaging, which allows exploration of gold nanoparticles in drug delivery for diagnostic purpose.  The pulsed laser ablation in liquid (PLAL) technique is a versatile synthetic and convincing technique due to its high efficiency, eco-friendly and facile method to produce gold nanoparticle.
  • 763
  • 16 May 2022
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