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Topic Review
Melatonin in Viral, Bacterial and Parasitic Infections
The current view of the origin of melatonin (MLT), chemically defined as N-acetyl-5-methoxytriptamine, suggests that MLT appeared on earth about 2.5 billion years ago. Indeed, it is proposed that at that time, anaerobic bacteria developed the ability to synthesize MLT as an adaptative response to increasing concentrations of oxygen in the atmosphere.
  • 156
  • 21 Mar 2024
Topic Review
SARS-CoV-2 ORF3a Protein as Therapeutic Target against COVID-19
The ORF3a (open reading frame 3a) protein found in SARS-CoV-2, represents a promising target for antiviral treatment due to its multifaceted role in viral pathogenesis, cytokine storms, disease severity, and mortality. ORF3a contributes significantly to viral pathogenesis by facilitating viral assembly and release, essential processes in the viral life cycle, while also suppressing the body’s antiviral responses, thus aiding viral replication. ORF3a also has been implicated in triggering excessive inflammation, characterized by NF-κB-mediated cytokine production, ultimately leading to apoptotic cell death and tissue damage in the lungs, kidneys, and the central nervous system. 
  • 64
  • 19 Mar 2024
Topic Review
HPV Behavior in Oral and Vaginal Cavity
Human genital papilloma virus infection is the most prevalent sexually transmitted infection in the world. It is estimated that more than 75% of sexually active women contract this infection in their lifetime. In 80% of young women, there is the clearance of the virus within 18–24 months.
  • 43
  • 18 Mar 2024
Topic Review
Microscopy Diagnosis of Trichomoniasis
More than one million curable sexually transmitted infections occur every day. Trichomonas vaginalis is one of the main infections responsible for these epidemiological data. The diagnosis of this protozoan is mainly based on microscopic and culture identification. 
  • 43
  • 15 Mar 2024
Topic Review
Genetic Variations and Antibiotic-Related Adverse Events
Antibiotic-related adverse events are common in both adults and children, and knowledge of the factors that favor the development of antibiotic-related adverse events is essential to limit their occurrence and severity. Genetics can condition the development of antibiotic-related adverse events, and the screening of patients with supposed or demonstrated specific genetic mutations may reduce drug-related adverse events.
  • 266
  • 14 Mar 2024
Topic Review
Sodium Toxicity and Immune Response in COVID-19
High dietary sodium intake leading to sodium toxicity is associated with comorbid conditions of COVID-19 such as hypertension, kidney disease, stroke, pneumonia, obesity, diabetes, hepatic disease, cardiac arrhythmias, thrombosis, migraine, tinnitus, Bell’s palsy, multiple sclerosis, systemic sclerosis, and polycystic ovary syndrome.
  • 39
  • 13 Mar 2024
Topic Review
Technologies for Plasmon-Based Fluorescence Enhancement
Fluorescence is a widely used phenomenon in various scientific and technological fields, including biology, chemistry, medicine, and materials science. The fluorescence signal provides valuable information about molecular interactions, concentrations, and structural changes. Fluorescence exhibits numerous valuable applications, encompassing the detection of single molecules, fluorescence nanoscopy, biological labeling, and optoelectronic device functionality, among many others. Fluorescence enhancement is imperative for enhancing the sensitivity and precision of a wide range of scientific and technological applications that heavily rely on fluorescence detection. It is a crucial requirement to elevate the performance and reliability of these applications.
  • 86
  • 11 Mar 2024
Topic Review
Role of Biofilm in Urinary Tract Infections
Urinary tract infections (UTIs) are prevalent bacterial infections in both community and healthcare settings. They account for approximately 40% of all bacterial infections and require around 15% of all antibiotic prescriptions. Although antibiotics have traditionally been used to treat UTIs for several decades, the significant increase in antibiotic resistance in recent years has made many previously effective treatments ineffective. Biofilm on medical equipment in healthcare settings creates a reservoir of pathogens that can easily be transmitted to patients. Urinary catheter infections are frequently observed in hospitals and are caused by microbes that form a biofilm after a catheter is inserted into the bladder. Managing infections caused by biofilms is challenging due to the emergence of antibiotic resistance. 
  • 64
  • 11 Mar 2024
Topic Review
Human Cytomegalovirus (HCMV) Genetic Diversity and Drug Resistance
Human cytomegalovirus (HCMV) is a pathogen with high prevalence in the general population that is responsible for high morbidity and mortality in immunocompromised individuals and newborns, while remaining mainly asymptomatic in healthy individuals. The HCMV genome is 236,000 nucleotides long and encodes approximately 200 genes in more than 170 open reading frames, with the highest rate of genetic polymorphisms occurring in the envelope glycoproteins. HCMV infection is treated with antiviral drugs such as ganciclovir, valganciclovir, cidofovir, foscarnet, letermovir and maribavir targeting viral enzymes, DNA polymerase, kinase and the terminase complex. One of the obstacles to successful therapy is the emergence of drug resistance, which can be tested phenotypically or by genotyping using Sanger sequencing, which is a widely available but less sensitive method, or next-generation sequencing performed in samples with a lower viral load to detect minority variants, those representing approximately 1% of the population. The prevalence of drug resistance depends on the population tested, as well as the drug, and ranges from no mutations detected to up to almost 50%. A high prevalence of resistance emphasizes the importance of testing the patient whenever resistance is suspected, which requires the development of more sensitive and rapid tests while also highlighting the need for alternative therapeutic targets, strategies and the development of an effective vaccine.
  • 49
  • 07 Mar 2024
Topic Review
Mycobacterium avium ssp. paratuberculosis and Crohn’s Disease
Mycobacterium avium ssp. paratuberculosis (MAP) is the cause of Johne’s disease (JD), which is a chronic infectious gastrointestinal disease of ruminants and is often fatal. In humans, MAP has been associated with Crohn’s disease (CD) for over a century, without conclusive evidence of pathogenicity. Numerous researchers have contributed to the subject, but there is still a need for evidence of the causation of CD by MAP.
  • 112
  • 07 Mar 2024
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