Topic Review
Morita Therapy
Morita therapy is an ecological, purpose-centered, response-oriented therapy created through case-based research by Shoma Morita, M.D. (1874–1938). Morita developed his theory of consciousness and medically-grounded four-stage progressive therapeutic method with rigor. The goal of Morita therapy is to have the patient accept life as it is. This does not mean that the patient cannot set and achieve goals, but be able to be satisfied with their life in the moment. Morita therapy places an emphasis on letting nature take its course. This is not to say that patients should be resigned to their mental illness but to respect the laws of nature. Feeling emotions is a law of nature according to Morita therapy. Morita therapy helps its patients understand that experiencing emotions, positive or negative, is a facet of being a human being. Morita describes his own therapy as follows: Morita therapy was originally developed to address shinkeishitsu, an outdated term used in Japan to describe patients who have various types of anxiety. Morita therapy was designed not to completely rid the patient of shinkeishitsu but to lessen the damaging effects. While Morita therapy has been described as cognate to Albert Ellis's rational-emotive therapy, this description does not account for the ecological foundation of the therapy. Morita therapy also has commonalities with existential and cognitive behavioral therapy.
  • 800
  • 10 Nov 2022
Topic Review
mPR-Mediated Signaling with Other Steroid Signaling Pathways
Progesterone (PRG) is a key cyclical reproductive hormone that has a significant impact on female organs in vertebrates. It is mainly produced by the corpus luteum of the ovaries, but can also be generated from other sources such as the adrenal cortex, Leydig cells of the testes and neuronal and glial cells. PRG has wide-ranging physiological effects, including impacts on metabolic systems, central nervous systems and reproductive systems in both genders. It was first purified as an ovarian steroid with hormonal function for pregnancy, and is known to play a role in pro-gestational proliferation during pregnancy.
  • 298
  • 05 Jun 2023
Topic Review
Multidrug Resistance Mechanisms and Nano-Treatments
The cellular mechanisms of drug resistance prevent the correct efficacy of the therapies used in various types of cancer and nanotechnology has been postulated as a possible alternative to avoid them. This entry focuses on describing the different mechanisms of drug resistance and dis-covering which nanotechnology-based therapies have been used in recent years to evade them in colon (CRC) and pancreatic cancer (PAC). Here we summarize the use of different types of nanotechnology (mainly nanoparticles) that have shown efficacy in vitro and in vivo in preclinical phases, allowing future in-depth research in CRC and PAC and its translation to future clinical trials.
  • 494
  • 02 May 2021
Topic Review
Multifunctional Magnetic Nanowires
Traditional cancer therapeutics are limited by factors such as multi-drug resistance and a plethora of adverse effect. These limitations need to be overcome for the progression of cancer treatment. In order to overcome these limitations, multifunctional nanosystems have recently been introduced into the market. The employment of multifunctional nanosystems provide for the enhancement of treatment efficacy and therapeutic effect as well as a decrease in drug toxicity.
  • 514
  • 26 Sep 2021
Topic Review
Multispecific Biotherapeutics
Multispecific biotherapeutic drugs are protein-based therapeutic molecules that can engage multiple drug-target binding interfaces concurrently.
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  • 21 Apr 2021
Topic Review
Muslim Heritage in Medicine
Many Greco Arabic Muslim scientists have contributed to the medicine field.
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  • 17 Aug 2022
Topic Review
N-Acetyl-Beta-D-Glucosaminidase in Kidney Injury
Acute and chronic kidney diseases are an evolving continuum for which reliable biomarkers of early disease are lacking. The potential use of glycosidases, enzymes involved in carbohydrate metabolism, in kidney disease detection has been under investigation since the 1960s. N-acetyl-beta-D-glucosaminidase (NAG) is a glycosidase commonly found in proximal tubule epithelial cells (PTECs).
  • 315
  • 18 Apr 2023
Topic Review
Nanomaterials as Inhibitors in EMT
Epithelial-mesenchymal transition (EMT) has emerged as a key regulator of cell invasion and metastasis in cancers. However, although EMT represents a relevant therapeutic target for cancer treatment, its application in the clinic is still limited due to various reasons, including appropriate drug delivery. Different nanomaterials may be used to counteract EMT induction, providing novel therapeutic tools against many different cancers. We discuss the application of various nanomaterials for EMT-based therapies in cancer, the therapeutic relevance of some of the proposed EMT targets, and the potential benefits and weaknesses of each approach.
  • 543
  • 11 Aug 2021
Topic Review
Nanosystems in Treating Lung Cancer
Even though there are various types of cancer, this pathology as a whole is considered the principal cause of death worldwide. Lung cancer is known as a heterogeneous condition, and it is apparent that genome modification presents a significant role in the occurrence of this disorder. There are conventional procedures that can be utilized against diverse cancer types, such as chemotherapy or radiotherapy, but they are hampered by the numerous side effects. Owing to the many adverse events observed in these therapies, it is imperative to continuously develop new and improved strategies for managing individuals with cancer. Nanomedicine plays an important role in establishing new methods for detecting chromosomal rearrangements and mutations for targeted chemotherapeutics or the local delivery of drugs via different types of nano-particle carriers to the lungs or other organs or areas of interest.
  • 360
  • 01 Sep 2021
Topic Review
Narrative Therapy
Narrative therapy (or Narraive Practice) is a form of psychotherapy that seeks to help patients identify their values and the skills associated with them. It provides the patient with knowledge of their ability to live these values so they can effectively confront current and future problems. The therapist seeks to help the patient co-author a new narrative about themselves by investigating the history of those values. Narrative therapy claims to be a social justice approach to therapeutic conversations, seeking to challenge dominant discourses that it claims shape people's lives in destructive ways. While narrative work is typically located within the field of family therapy, many authors and practitioners report using these ideas and practices in community work, schools and higher education. Narrative therapy has come to be associated with collaborative as well as person-centered therapy.
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  • 31 Oct 2022
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