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Topic Review
High Energy Nuclear Physics
High-energy nuclear physics studies the behaviour of nuclear matter in energy regimes typical of high energy physics. The primary focus of this field is the study of heavy-ion collisions, as compared to lower atomic mass atoms in other particle accelerators. At sufficient collision energies, these types of collisions are theorized to produce the quark–gluon plasma. In peripheral nuclear collisions at high energies one expects to obtain information on the electromagnetic production of leptons and mesons which are not accessible in electron-positron colliders due to their much smaller luminosities. Previous high-energy nuclear accelerator experiments have studied heavy-ion collisions using projectile energies of 1 GeV/nucleon up to 158 GeV/nucleon. Experiments of this type, called "fixed target" experiments, primarily accelerate a "bunch" of ions (typically around [math]\displaystyle{ 10^6 }[/math] to [math]\displaystyle{ 10^8 }[/math] ions per bunch) to speeds approaching the speed of light (0.999c) and smash them into a target of similar heavy ions. While all collision systems are interesting, great focus was applied in the late 1990s to symmetric collision systems of gold beams on gold targets at Brookhaven National Laboratory's Alternating Gradient Synchrotron (AGS) and uranium beams on uranium targets at CERN's Super Proton Synchrotron. Currently, high-energy nuclear physics experiments are being conducted at Brookhaven National Laboratory's Relativistic Heavy Ion Collider (RHIC) and in CERN's new Large Hadron Collider. The four primary experiments at RHIC (PHENIX, STAR, PHOBOS, and BRAHMS) study collisions of highly relativistic nuclei. Unlike fixed target experiments, collider experiments steer two accelerated beams of ions toward each other at (in the case of RHIC) six interaction regions. At RHIC, ions can be accelerated (depending on the ion size) from 100 GeV/nucleon to 250GeV/nucleon. Since each colliding ion possesses this energy moving in opposite directions, the maximum energy of the collisions can achieve a center of mass collision energy of 200GeV/nucleon for gold and 500GeV/nucleon for protons. The ALICE (A Large Ion Collider Experiment) detector at the LHC at CERN is specialized in studying Pb-Pb nuclei collisions at a centre of mass energy of 2.76 TeV per nucleon pair. Other LHC detectors like CMS, ATLAS, and LHCb also have heavy ion programs.
  • 286
  • 20 Oct 2022
Topic Review
High Entropy Alloys
High-entropy alloys (HEAs) are alloys that are formed by mixing equal or relatively large proportions of (usually) five or more elements. Prior to the synthesis of these substances, typical metal alloys comprised one or two major components with smaller amounts of other elements. For example, additional elements can be added to iron to improve its properties, thereby creating an iron based alloy, but typically in fairly low proportions, such as the proportions of carbon, manganese, and the like in various steels. Hence, high entropy alloys are a novel class of materials. The term “high-entropy alloys” was coined because the entropy increase of mixing is substantially higher when there is a larger number of elements in the mix, and their proportions are more nearly equal. These alloys are currently the focus of significant attention in materials science and engineering because they have potentially desirable properties. Furthermore, research indicates that some HEAs have considerably better strength-to-weight ratios, with a higher degree of fracture resistance, tensile strength, as well as corrosion and oxidation resistance than conventional alloys. Although HEAs have been studied since the 1980s, research substantially accelerated in the 2010s.
  • 2.5K
  • 01 Dec 2022
Topic Review
High-Gradient Ion Linacs for FLASH-RT
Synchrotrons are used for ion beam therapy, while cyclotrons are mainly used for proton therapy. Linacs were not seriously considered for ion beam therapy due to the required accelerator length and extended footprint. With the developments of high-frequency high-gradient accelerating copper structures, more compact linacs are being proposed for protons and ions. These structures should be capable of delivering FLASH beam intensities.
  • 313
  • 24 May 2023
Topic Review
High-Performance Silicon Optoelectronic Devices Based on Graphene
Graphene—a two-dimensional allotrope of carbon in a single-layer honeycomb lattice nanostructure—has several distinctive optoelectronic properties that are highly desirable in advanced optical communication systems. Meanwhile, silicon photonics is a promising solution for the next-generation integrated photonics, owing to its low cost, low propagation loss and compatibility with CMOS fabrication processes.
  • 477
  • 19 Jan 2022
Topic Review
High-Precision Quantum Tests of the Weak Equivalence Principle
General relativity has been the best theory to describe gravity and space–time and has successfully explained many physical phenomena. At the same time, quantum mechanics provides the most accurate description of the microscopic world, and quantum science technology has evoked a wide range of developments today. Merging these two very successful theories to form a grand unified theory is one of the most elusive challenges in physics. All the candidate theories that wish to unify gravity and quantum mechanics predict the breaking of the weak equivalence principle, which lies at the heart of general relativity. It is therefore imperative to experimentally verify the equivalence principle in the presence of significant quantum effects of matter. Cold atoms provide well-defined properties and potentially nonlocal correlations as the test masses and will also improve the limits reached by classical tests with macroscopic bodies. The results of rigorous tests using cold atoms may tell us whether and how the equivalence principle can be reformulated into a quantum version. 
  • 273
  • 26 Sep 2023
Topic Review
High-Precision Trace Hydrogen Sensing
Despite its growing importance in the energy generation and storage industry, the detection of hydrogen in trace concentrations remains challenging, as established optical absorption methods are ineffective in probing homonuclear diatomics. Besides indirect detection approaches using, e.g., chemically sensitized microdevices, Raman scattering has shown promise as an alternative direct method of unambiguous hydrogen chemical fingerprinting. 
  • 492
  • 13 Jun 2023
Topic Review
High-Resolution Transmission Electron Microscopy
High-resolution transmission electron microscopy is an imaging mode of specialized transmission electron microscopes that allows for direct imaging of the atomic structure of samples. It is a powerful tool to study properties of materials on the atomic scale, such as semiconductors, metals, nanoparticles and sp2-bonded carbon (e.g., graphene, C nanotubes). While this term is often also used to refer to high resolution scanning transmission electron microscopy, mostly in high angle annular dark field mode, this article describes mainly the imaging of an object by recording the two-dimensional spatial wave amplitude distribution in the image plane, in analogy to a "classic" light microscope. For disambiguation, the technique is also often referred to as phase contrast transmission electron microscopy. At present, the highest point resolution realised in phase contrast transmission electron microscopy is around 0.5 ångströms (0.050 nm). At these small scales, individual atoms of a crystal and its defects can be resolved. For 3-dimensional crystals, it may be necessary to combine several views, taken from different angles, into a 3D map. This technique is called electron crystallography. One of the difficulties with high resolution transmission electron microscopy is that image formation relies on phase contrast. In phase-contrast imaging, contrast is not intuitively interpretable, as the image is influenced by aberrations of the imaging lenses in the microscope. The largest contributions for uncorrected instruments typically come from defocus and astigmatism. The latter can be estimated from the so-called Thon ring pattern appearing in the Fourier transform modulus of an image of a thin amorphous film.
  • 937
  • 15 Nov 2022
Topic Review
High-Spectral-Resolution Lidar
High-spectral-resolution lidar (HSRL) is a powerful tool for atmospheric aerosol remote sensing. A ground-based high-spectral-resolution lidar (HSRL), operated at 532 nm wavelength, has been developed at Zhejiang University (ZJU) for aerosols and clouds studies. This lidar provides vertical profiles of aerosol scattering ratio together with lidar ratio and particle depolarization ratio at 532 nm. Determination of overlap function is a key step in the calibration of a high-spectral-resolution lidar (HSRL) and important guarantee of data retrieval, an iterative-based general determination (IGD) method for overlap function in HSRL is proposed. The standard method to retrieve the extinction coefficient from HSRL signals depends heavily on the signal-to-noise ratio (SNR). An iterative image reconstruction (IIR) method is proposed for the retrieval of the aerosol extinction coefficient based on HSRL data under low SNR condition. With the optical properties, a state-of-the-art method for feature detection and classification is proposed to automatically identify the features attributed to dust/polluted dust, urban/smoke, maritime aerosols, as well as ice and liquid water cloud during day and night.
  • 1.6K
  • 22 Feb 2021
Topic Review
High-Throughput Screening
HTS involves in vitro, cell- or whole organism- based assays. The most common readouts for biochemical assays in HTS are optical, including absorbance, fluorescence, luminescence, and scintillation.
  • 949
  • 21 Jul 2021
Topic Review
High-Throughput Screening Methods for Radiosensitivity and Resistance
The biological impact of ionizing radiation (IR) on humans depends not only on the physical properties and absorbed dose of radiation but also on the unique susceptibility of the exposed individual. A critical target of IR is DNA, and the DNA damage response is a safeguard mechanism for maintaining genomic integrity in response to the induced cellular stress. Unrepaired DNA lesions lead to various mutations, contributing to adverse health effects.
  • 455
  • 19 Aug 2022
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