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Topic Review
Powdery Mildew Resistance in Cannabis
Powdery mildew (PM) is one of the most common Cannabis sativa diseases. In spite of this, very few documented studies have characterized the resistance genes involved in PM defense mechanisms, or sources of natural genetic resistance in cannabis.
  • 215
  • 04 Jan 2024
Topic Review
Small Molecules to Enhance Gene Therapy
In the rapidly evolving landscape of genetic engineering, the advent of CRISPR-Cas technologies has catalyzed a paradigm shift, empowering scientists to manipulate the genetic code with unprecedented accuracy and efficiency. Despite the remarkable capabilities inherent to CRISPR-Cas systems, recent advancements have witnessed the integration of small molecules to augment their functionality, introducing new dimensions to the precision and versatility of gene editing applications. 
  • 147
  • 03 Jan 2024
Topic Review
Nano-Agrochemicals
Nano-agrochemicals (NACs) are nanomaterials and formulations specifically designed and controlled at the nanoscale. They can be defined as agricultural formulations in the form of nanopesticides (NPCs) which have unique properties (high aspect ratio) due to elements ranging in nanometer size (up to 100 nm). They have the potential to revolutionize agriculture through the promotion of efficient and ecofriendly NPCs with properties such as target specificity, the ability to control usage, and high surface area which allow the targeted delivery of nutrients and protection of crop yields. NACs, or nanotechnology-based agrochemicals, have gained considerable attention in recent years due to extensive research and development efforts. These cutting-edge products harness the special qualities of NPs to improve the effectiveness, safety, and ecofriendliness of conventional agrochemicals. This technology has emerged as a valuable tool in the agricultural sector, offering novel and efficient solutions for conventional agricultural methods and practices. Some of these include NPCs, among other NACs, which have the capacity to revolutionize agriculture by enhancing sustainability and efficiency. These NPCs, ranging in size from 1 to 200 nm, serve as a vehicle to transport agrochemical ingredients (AcI). With unique properties, they outperform conventional pesticides by 31.5% in managing crop pathogens, weeds, and insects. These unique properties include enhanced water solubility, improved bioavailability, and increased protection of agrochemicals from environmental degradation. Thus, NPCs address the drawbacks of conventional pesticides such as limited availability, susceptibility to degradation from light, and the negative effects of organic solvent pollution.
  • 625
  • 03 Jan 2024
Topic Review
Combination Immunotherapiess for Renal cell carcinoma
Renal cell carcinoma (RCC) constitutes a considerable burden on public health, with an estimated 81,800 new diagnoses and 14,890 mortality cases predicted for 2023 in the United States alone. Over the recent years, the incidence of RCC has exhibited a consistent upward trend. Among the various subtypes, clear cell renal cell carcinoma (ccRCC) predominates, accounting for approximately 70–80% of RCC cases, with the majority originating from the proximal convoluted tubule. Conversely, the non-clear cell renal cell carcinomas (nccRCCs), encompassing entities such as papillary, chromophobe, translocation, and medullary RCC, as well as collecting duct carcinoma, comprise 20–30% of RCC and harbor distinct histopathological and molecular characteristics.
  • 133
  • 03 Jan 2024
Topic Review
Fermented Vegetables
Fermentation is a traditional method used to preserve vegetables. Many regions worldwide have a tradition of consuming fermented vegetables. Numerous fermented vegetables exist according to the raw materials, formula, and fermentation technologies used. Typical fermented vegetables include sauerkraut, paocai, zhacai, and kimchi. The primary constituents for producing fermented vegetables are cruciferous vegetables, such as cabbage, kale, mustard green, or radish. Other prevalent vegetables include chili pepper, lotus root, carrot, ginger, cucumber, eggplant, beetroot, garlic, olive, papaya, and chayote. There are variations in the production procedures used for different fermented vegetables. 
  • 331
  • 03 Jan 2024
Topic Review
A Challenging Story of Schizophrenia and Glutathione
Schizophrenia (SZ) is a devastating mental illness with a complex and heterogeneous clinical state. Oxidative stress, and in particular glutathione (GSH) dysregulation, has been demonstrated to play a crucial role in SZ pathophysiology. In fact, glutathione is a leading actor of oxidative-stress-mediated damage in SZ and appears to reflect the heterogeneity of the disease.
  • 219
  • 03 Jan 2024
Topic Review
State-of the-Art Constraint-Based Modeling of Microbial Metabolism
Methanotrophy is the ability of an organism to capture and utilize the greenhouse gas, methane, as a source of energy-rich carbon. Over the years, significant progress has been made in understanding of mechanisms for methane utilization, mostly in bacterial systems, including the key metabolic pathways, regulation and the impact of various factors (iron, copper, calcium, lanthanum, and tungsten) on cell growth and methane bioconversion. The implementation of -omics approaches provided vast amount of heterogeneous data that require the adaptation or development of computational tools for a system-wide interrogative analysis of methanotrophy. The genome-scale mathematical modeling of its metabolism has been envisioned as one of the most productive strategies for the integration of muti-scale data to better understand methane metabolism and enable its biotechnological implementation. 
  • 286
  • 03 Jan 2024
Topic Review
Yin and Yang of IκB Kinases in Cancer
IκB kinases (IKKs), specifically IKKα and IKKβ, have long been recognized for their pivotal role in the NF-κB pathway, orchestrating immune and inflammatory responses.
  • 236
  • 03 Jan 2024
Topic Review
E2F-RB-p53 Pathway in Tumor Suppression
The transcription factor E2F links the RB pathway to the p53 pathway upon loss of function of pRB, thereby playing a pivotal role in the suppression of tumorigenesis. E2F fulfills a major role in cell proliferation by controlling a variety of growth-associated genes. The activity of E2F is controlled by the tumor suppressor pRB, which binds to E2F and actively suppresses target gene expression, thereby restraining cell proliferation. Signaling pathways originating from growth stimulative and growth suppressive signals converge on pRB (the RB pathway) to regulate E2F activity. In most cancers, the function of pRB is compromised by oncogenic mutations, and E2F activity is enhanced, thereby facilitating cell proliferation to promote tumorigenesis. Upon such events, E2F activates the Arf tumor suppressor gene, leading to activation of the tumor suppressor p53 to protect cells from tumorigenesis. ARF inactivates MDM2, which facilitates degradation of p53 through proteasome by ubiquitination (the p53 pathway). P53 suppresses tumorigenesis by inducing cellular senescence or apoptosis. Hence, in almost all cancers, the p53 pathway is also disabled. 
  • 181
  • 03 Jan 2024
Topic Review
The Interactions between Microorganisms and Arsenic
While arsenic is a natural and inevitable part of the biogeochemical cycle, the rise in anthropogenic activities has led to its continued increase in arsenic concentrations in various environmental matrices. High arsenic concentration is considered a threat due to its recalcitrant nature as well as its capacity for highly toxic effects in plants, animals, and humans. Among all domains of life, microorganisms have been dealing with arsenic since life arose and are the most resilient to its lethal effects. Strides in elucidating the biochemical pathways of their ability to detoxify arsenic has allowed us to utilize their potential in bioremediation processes. 
  • 245
  • 03 Jan 2024
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