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Topic Review
Biography
Topic Review
Alcohol-Induced Liver Injury in Brief
Alcoholic liver disease (ALD) is a global health concern, representing a spectrum of liver disorders resulting from chronic alcohol consumption. To decipher the intricate mechanisms underlying ALD and develop effective therapies, researchers have turned to experimental models. Among these, the alcohol-induced liver injury model, accomplished through chronic alcohol administration to animals, has been pivotal in elucidating key pathophysiological aspects of ALD. This research navigates through the methodologies employed to induce liver injury, highlights the diverse pathological features observed, explores the underlying mechanisms, and discusses the model's relevance in advancing our understanding of ALD. Additionally, it delves into the multifaceted applications of this model in the quest for novel therapeutic strategies to combat ALD.
261
08 Oct 2023
Topic Review
Alcohol-Poisoning Symptoms
Lactic Acid Bacteria (LAB) are recognized as “probiotics.” The word “probiotics” is defined as “the live microorganisms conferring a health benefit on the host when administered in adequate amounts”, and probiotic LAB strains traditionally have been used to manufacture fermented foods. It has been reported that some LAB cells and fermented foods containing the bacteria have potent health benefits, such as promoting intestinal homeostasis, possessing anti-allergic properties, and preventing and improving obesity.
757
01 Nov 2020
Topic Review
Alcoholic Fermentation in Fruit Spirits
Fermentation is a metabolic process of conversion of an organic substrate by the action of enzymes. It is a completely natural process that occurs unhindered in nature.
792
16 May 2023
Topic Review
ALDH in Gynecologic Malignancies
Gynecologic cancers cause over 600,000 deaths annually in women worldwide. The development of chemoresistance after initial rounds of chemotherapy contributes to tumor relapse and death due to gynecologic malignancies. In this regard, cancer stem cells (CSCs), a subpopulation of stem cells with the ability to undergo self-renewal and clonal evolution, play a key role in tumor progression and drug resistance. Aldehyde dehydrogenases (ALDH) are a group of enzymes shown to be robust CSC markers in gynecologic and other malignancies. These enzymes also play functional roles in CSCs, including detoxification of aldehydes, scavenging of reactive oxygen species (ROS), and retinoic acid (RA) signaling, making ALDH an attractive therapeutic target in various clinical scenarios. In this review, we discuss the critical roles of the ALDH in driving stemness in different gynecologic malignancies. We review inhibitors of ALDH, both general and isoform-specific, which have been used to target CSCs in gynecologic cancers. Many of these inhibitors have been shown to be effective in preclinical models of gynecologic malignancies, supporting further development in the clinic. Furthermore, ALDH inhibitors, including 673A and CM037, synergize with chemotherapy to reduce tumor growth. Thus, ALDH-targeted therapies hold promise for improving patient outcomes in gynecologic malignancies.
620
20 Feb 2021
Topic Review
Aldose Reductase
Aldose reductase (AR) is a member of the reduced nicotinamide adenosine dinucleotide phosphate (NADPH)-dependent aldo-keto reductase superfamily. It is also the rate-limiting enzyme of the polyol pathway, catalyzing the conversion of glucose to sorbitol, which is subsequently converted to fructose by sorbitol dehydrogenase. AR is highly expressed by Schwann cells in the peripheral nervous system (PNS). The excess glucose flux through AR of the polyol pathway under hyperglycemic conditions has been suggested to play a critical role in the development and progression of diabetic peripheral neuropathy (DPN).
1.1K
09 Feb 2021
Topic Review
Aldosterone
Aldosterone is a steroid hormone that is produced in the adrenal cortex. Its major renal effect is to regulate electrolyte and water homeostasis in the distal tubule, thus maintaining blood pressure and extracellular fluid homeostasis through the activation of mineralocorticoid receptors (MR) in epithelial cells [2]. Aldosterone enters an epithelial cell and binds to the MR. The complex of aldosterone and MR translocates into the nucleus and regulates gene transcription of, among others, the epithelial sodium channel (ENaC) and the signaling proteins and kinases that impact channel and transporter activity, such as serum/glucocorticoid kinases (SGKs).
1.9K
30 Oct 2020
Biography
Alec (Alirza) Rasizade
Alec (Alirza) Rasizade (Azerbaijani: Əli Rasizadə) is a retired Azeri-American professor of history and political science, who specialized in Sovietology, primarily known for the typological model (or "algorithm" in his own words), which describes the impact of a drop in oil revenues on the process of decline in rentier states by stages and cycles of their general socio-economic degradation up
537
17 Nov 2022
Topic Review
Aleeta
Aleeta curvicosta (commonly known as the floury baker or floury miller, known until 2003 as Abricta curvicosta) is a species of cicada, one of Australia's most familiar insects. Native to the continent's eastern coastline, it was described in 1834 by Ernst Friedrich Germar. The floury baker is the only described species in the genus Aleeta. The floury baker's distinctive appearance and loud call make it popular with children. Both the common and genus name are derived from the white, flour-like filaments covering the adult body. Its body and eyes are generally brown with pale patterns including a light-coloured line along the midline of the pronotum. Its forewings have distinctive dark brown patches at the base of two of their apical cells. The female is larger than the male, although species size overall varies geographically, with larger animals associated with regions of higher rainfall. The male has distinctive genitalia and a loud and complex call generated by the frequent buckling of ribbed tymbals and amplified by abdominal air sacs. The floury baker is solitary and occurs in low densities. Individuals typically emerge from the soil through a three-month period from late November to late February, and can be encountered until May. The floury baker is found on a wide variety of trees, with some preference for species of paperbark (Melaleuca). It is a relatively poor flier, preyed upon by cicada killer wasps and a wide variety of birds, and can succumb to a cicada-specific fungal disease.
981
03 Nov 2022
Biography
Aleister Crowley
Aleister Crowley (/ˈæleɪstər ˈkroʊli/; born Edward Alexander Crowley; 12 October 1875 – 1 December 1947) was an English occultist, ceremonial magician, poet, painter, novelist, and mountaineer. He founded the religion of Thelema, identifying himself as the prophet entrusted with guiding humanity into the Æon of Horus in the early 20th century. A prolific writer, he published widely over
2.0K
22 Nov 2022
Biography
Aleksandr Markevich
Oleksandr Prokopovych Markevych (Ukrainian: Олександр Прокопович Маркевич), in English more often Aleksandr Prokofyevich Markevich (Russian: Александр Прокофьевич Маркевич) (19 March 1905 – 23 April 1999) was a Ukrainian zoologist, and a prolific helminthologist and copepodologist. He was professor and an Academician of the National Academ
369
21 Nov 2022
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