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Topic Review
Viral Infections and Thymus
The thymus gland is a primary lymphoid organ for T-cell development. T-cells are one of the white blood cells that play a critical role in adaptive immune response. Various viral infections can result in the disturbance of thymic functions.
  • 1.5K
  • 17 Jun 2021
Topic Review
Viral Infection-Mediated Pulmonary Epigenetics
Respiratory viral infections can trigger chronic lung diseases. Number of studies have shown that respiratory viral infection causes epigenetic changes, which refer to genetic alterations that affect gene expression without any mutational genetic changes.
  • 242
  • 12 Jul 2023
Topic Review
Viral Hepatitis and HCC Development
Hepatocellular carcinoma (HCC) is driven by chronic liver diseases that exhibit several rounds of liver inflammation, necrosis, and regeneration making, HCC a paradigm for inflammation-driven cancer. The role of viral and non-viral inflammation in genetic perturbation and chromosomal aberration predisposing HCC is well-characterized. Instead, the focus of the entry is to summarize the impact of viral hepatitis-mediated immune deregulation on the development and progression of HCC.
  • 436
  • 25 Mar 2022
Topic Review
Viral Equine Encephalitis
Neurological disorders represent an important sanitary and economic threat for the equine industry worldwide. Among nervous diseases, viral encephalitis is of growing concern, due to the emergence of arboviruses and to the high contagiosity of herpesvirus-infected horses. The nature, severity and duration of the clinical signs could be different depending on the etiological agent and its virulence. However, definite diagnosis generally requires the implementation of combinations of direct and/or indirect screening assays in specialized laboratories. The equine practitioner, involved in a mission of prevention and surveillance, plays an important role in the clinical diagnosis of viral encephalitis. The general management of the horse is essentially supportive, focused on controlling pain and inflammation within the central nervous system, preventing injuries and providing supportive care. Despite its high medical relevance and economic impact in the equine industry, vaccines are not always available and there is no specific antiviral therapy. In this review, the major virological, clinical and epidemiological features of the main neuropathogenic viruses inducing encephalitis in equids in Europe, including rabies virus (Rhabdoviridae), Equid herpesviruses (Herpesviridae), Borna disease virus (Bornaviridae) and West Nile virus (Flaviviridae), as well as exotic viruses, will be presented.
  • 1.2K
  • 29 Oct 2020
Topic Review
Viral Enteritis in Cattle
Livestock products supply about 13 percent of energy and 28 percent of protein in diets consumed worldwide. Diarrhea is a leading cause of sickness and death of beef and dairy calves in their first month of life and also affecting adult cattle, resulting in large economic losses and a negative impact on animal welfare. Despite the usual multifactorial origin, viruses are generally involved, being among the most important causes of diarrhea. There are several viruses that have been confirmed as etiological agents (i.e., rotavirus and coronavirus), and some viruses that are not yet confirmed as etiological agents. 
  • 670
  • 03 Sep 2021
Topic Review
Viral Ejection Proteins
Genes encoding ejection proteins are commonly found in Podoviridae phages that infect Gram-negative bacteria, including Enterobacteriaceae, Mycobacteria, Pseudomonadaceae, and Cyanobacteria.
  • 490
  • 11 Mar 2022
Topic Review
Viper Venom Phospholipase A2
Viper venom phospholipase A2 enzymes (vvPLA2s) and phospholipase A2-like (PLA2-like) proteins are two of the principal toxins in viper venom that are responsible for the severe myotoxic and neurotoxic effects caused by snakebite envenoming, among other pathologies. 
  • 161
  • 22 Feb 2024
Topic Review
Vine and Wine Sustainability in a Cooperative Ecosystem
The world is changing, and climate change has become a serious issue. Organizations, governments, companies, and consumers are becoming more conscious of this impact and are combining their forces to minimize it. Cooperatives have a business model that differs from those in the private or public sector. They operate according to their own principles of cooperation, which makes it difficult to obtain results that are in harmony with the objectives of the organization and the cooperative members.
  • 198
  • 03 Nov 2023
Topic Review
Vincristine-Induced Pediatric Peripheral Neuropathy
Vincristine-induced peripheral neurotoxicity (VIPN) is a very common side effect of vincristine chemotherapy among pediatric patients with cancer. 
  • 848
  • 21 May 2021
Topic Review
Vincent's Disease
Acute necrotizing ulcerative gingivitis (ANUG) is a common, non-contagious infection of the gums with sudden onset. The main features are painful, bleeding gums, and ulceration of inter-dental papillae (the sections of gum between adjacent teeth). This disease, along with necrotizing (ulcerative) periodontitis (NP or NUP) is classified as a necrotizing periodontal disease, one of the seven general types of gum disease caused by inflammation of the gums (periodontitis). The often severe gum pain that characterizes ANUG distinguishes it from the more common chronic periodontitis which is rarely painful. If ANUG is improperly treated or neglected, it may become chronic and/or recurrent. The causative organisms are mostly anaerobic bacteria, particularly Fusobacteriota and spirochete species. Predisposing factors include poor oral hygiene, smoking, poor nutrition, psychological stress, and a weakened immune system. When the attachments of the teeth to the bone are involved, the term NUP is used. Treatment of ANUG is by removal of dead gum tissue and antibiotics (usually metronidazole) in the acute phase, and improving oral hygiene to prevent recurrence. Although the condition has a rapid onset and is debilitating, it usually resolves quickly and does no serious harm. The informal name trench mouth arose during World War I as many soldiers developed the disease, probably because of the poor conditions and extreme psychological stress.
  • 655
  • 30 Nov 2022
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