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Topic Review
Stem Cell Therapy for Infertility
Stem cells are a subtype of cells that remain in undifferentiated form in embryos and in adult tissues and can self-renew and differentiate as and when required. Stem cells in differentiated organs contribute to the restoration of function through organ damage repair. According to their origin, stem cells are classified as embryonic stem cells (ESC), adult stem cells (includes mesenchymal stem cells MSC), induced pluripotent stem cells (iPSC), spermatogonial stem cells (SSCs), and ovarian stem cells. Stem Cells can be applicable for several disorders including infertility both in male and female.
  • 883
  • 22 Jul 2021
Topic Review
Rumex dentatus L.
Herbicide resistance in weeds is a global threat to sustaining food security. In India, herbicide-resistant Phalaris minor was the major problem in wheat for more than two decades, but the continuous use of metsulfuron-methyl (an ALS inhibitor) to control broadleaf weeds has resulted in the evolution of ALS inhibitor-resistant Rumex dentatus L. This review summarizes the current scenario of herbicide resistance in R. dentatus, along with its ecology and management perspectives. Studies have provided valuable insights on the emergence pattern of R. dentatus under different environments in relation to tillage, cropping systems, nutrients, and irrigation. Moreover, R. dentatus has exhibited higher emergence under zero tillage, with high infestation levels in rice-wheat compared to other wheat-based cropping systems (sorghum-wheat). Alternative herbicides for the management of resistant R. dentatus include pendimethalin, 2,4-D, carfentrazone, isoproturon, and metribuzin. Although the pre-emergence application of pendimethalin is highly successful in suppressing R. dentatus, but its efficiency is questionable under lower field soil moisture and heavy residue load conditions. Nevertheless, the biological data may be utilized to control R. dentatus. Therefore, herbicide rotation with suitable spray techniques, collecting weed seeds at differential heights from wheat, crop rotation, alternate tillage practices, and straw retention are recommended for addressing the resistance issue in R. dentatus in North India conditions. Overall, we discuss the current state of herbicide resistance in R. dentatus, the agronomic factors affecting its population, its proliferation in specific cropping systems (rice-wheat), and management strategies for containing an infestation of a resistant population. 
  • 883
  • 29 Jun 2021
Topic Review
Calcium Dysregulation in Alzheimer’s Disease
Intracellular calcium (Ca2+) is an important second messenger that regulates multiple cellular functions, such as synaptic plasticity, action potentials, and learning and memory. Ca2+ dyshomeostasis, on the other hand, contributes to detrimental mechanisms such as necrosis, apoptosis, autophagy deficits, and neurodegeneration. Perturbations in intracellular Ca2+ are involved in many neurodegenerative diseases including Alzheimer's disease (AD), Parkinson’s disease, and Huntington’s disease.  Ca2+ dyshomeostasis is an early event in the AD timeline. Ca2+ dysregulation in AD comes as a result of hyperactivity of Ca2+ channels in the plasma membrane and intracellular compartments. It does not seem to be restricted to neurons, but rather is a global phenomenon that affects many cell types in the brain.
  • 883
  • 25 Dec 2020
Topic Review
Factors Affecting the Structural Quality of Tissue Protein
Tissue proteins or textured vegetable proteins (with a lean fiber-like structure and chewiness) form the main skeletal structure of plant-based meat alternative products. These can be obtained through techniques such as extrusion, shearing, spinning, freezing structuring and three-dimensional (3D) printing. The main constituents of tissue proteins are proteins, lipids, water, carbohydrates, flavoring agents and coloring agents. The choice of plant protein raw materials, with their various processing characteristics, prior to processing is a decisive factor in structural quality differentiation.
  • 882
  • 09 Aug 2022
Topic Review
Osteoclasts
There are sexually dimorphic differences in osteoclast formation and function that may have significant importance for understanding why females are prone to have a lower bone mass than males at any given age and are at increased risk for osteoporosis. Osteoclasts are the principal mediators of bone resorption. They form through the fusion of mononuclear precursor cells under the principal influence of the cytokines macrophage colony stimulating factor (M-CSF, aka CSF-1) and receptor activator of NF-κB ligand (RANKL, aka TNFSF11).
  • 882
  • 04 Nov 2020
Topic Review
Seed Geometry in the Vitaceae
The Vitaceae Juss., in the basal lineages of Rosids, contains sixteen genera and 950 species, mainly of tropical lianas. The family has been divided in five tribes: Ampelopsideae, Cisseae, Cayratieae, Parthenocisseae and Viteae. Seed shape is variable in this family and is described based on the comparison of bi-dimensional seed images with geometric models. Ten morphological types are described in the Vitaceae. Seven of them are general and three specific. Among the general types, three are shared with the Arecaceae and correspond to geometric figures well described (lenses, superellipses and elongated waterdrops). Four additional groups include waterdrops, normal or rounded, heart curves, normal or rounded, elongated heart curves and other elongated curves, respectively. Finally, the three specific types correspond to heart curves of the Cayratia and Pseudocayratia types, heart curves of the Squared Heart Curve (SqHC) type of Ampelocissus and Ampelopsis, and Elongated Superellipse-Heart Curves (ESHCs), frequent in Tetrastigma species and observed also in Cissus species and R. rhomboidea. All these groups are defined by geometric models obtained by the representation of algebraic equations. Modifications in the equations result in models adjusting to the shape of seeds for each species.
  • 882
  • 13 Sep 2021
Topic Review
Rheumatic Manifestations for ICIs
Immune checkpoint inhibitors (ICI) are monoclonal antibodies that activate the immune system aiming at enhancing antitumor immunity.  Their clinical efficacy is well documented but the side effects associated with their use are still under investigation.  These drugs cause several immune related adverse events (ir-AE) some of which stand within the field of Rheumatology.  Herein, we performed a literature review in an effort to evaluate all publicly available clinical data regarding rheumatic manifestations associated with ICI.  The most common musculoskeletal ir-AEs are inflammatory arthritis, polymyalgia rheumatica and myositis.  Non musculoskeletal rheumatic manifestations are less frequent with the most prominent being sicca, vasculitides and sarcoidosis.  Cases of systemic lupus erythematosus or scleroderma are extremely rare.  The majority of musculoskeletal ir-AE are of mild/moderate severity and can be managed with steroids with no need for ICI discontinuation.  In severe cases, more intense immunosuppressive therapy and permanent ICI discontinuation may be employed.  Oncologists should periodically screen patients receiving ICI for new onset inflammatory musculoskeletal complaints and seek a rheumatology consultation in cases of persisting symptoms.
  • 882
  • 28 Oct 2020
Topic Review
Animal Resilience
Resilience is conceived as a dynamic developmental process involving the achievement of positive adaptation within the context of significant adversity. Resilience is not a unique ability but rather a set of capacities of a system put in place to absorb a disturbance and to reorganize while trying to retain the same function, structure, and identity. This study describes the characteristics and the molecular mechanisms of resilience to understand the core elements of resilience and its indicators.
  • 882
  • 08 Jan 2021
Topic Review
Wine
Dietary habits are a determining factor of the higher incidence and prevalence of chronic non-communicable diseases (NCDs). In the aim to find a possible preventive and intervention strategy, the Mediterranean diet (MedDiet) has been proposed as an effective approach. Within the MedDiet, moderate wine consumption with meals is a positive item in the MedDiet score; however, recent studies have reported a dose-response association between alcohol consumption and higher risk of a large number of NCDs. This review aimed to evaluate the association between NCDs and wine consumption in the framework of the MedDiet, with a simple review of 22 studies of the highest-level literature published over the last five years. We found that the information regarding the effects of wine in different health outcomes has not varied widely over the past five years, finding inconclusive results among the studies evaluated. Most of the literature agrees that light to moderate wine intake seems to have beneficial effects to some extent in NCDs, such as hypertension, cancer, dyslipidemia and dementia, but no definitive recommendations can be made on a specific dose intake that can benefit most diseases.
  • 882
  • 11 Feb 2021
Topic Review
Serum lipidomics in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a highly debilitating chronic inflammatory autoimmune disease most prevalent in women. The true etiology of this disease is complex, multifactorial, and is yet to be completely elucidated. Changes in the lipid profile at a molecular level in RA are still poorly understood. Studies on the variation of lipid profile in RA using lipidomics showed that fatty acid and phospholipid profile, especially in phosphatidylcholine and phosphatidylethanolamine, are affected in this disease. These promising results could lead to the discovery of new diagnostic lipid biomarkers for early diagnosis of RA and targets for personalized medicine.
  • 882
  • 15 Jan 2021
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