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Topic Review
Function of platelet lipid rafts
Lipid rafts are dynamic assemblies of glycosphingolipids, sphingomyelin, cholesterol, and specific proteins which are stabilized into platforms involved in the regulation of vital cellular processes. Recent reports have demonstrated that lipid rafts are spatially and compositionally heterogeneous in the single-cell membrane. Sphingomyelin-rich rafts that are spatially and functionally distinct from the cholesterol-rich rafts are found at spreading platelets. Fibrin is translocated to sphingomyelin-rich rafts and platelet sphingomyelin-rich rafts act as platforms where extracellular fibrin and intracellular actomyosin join to promote clot retraction.
  • 921
  • 07 Aug 2020
Topic Review
Sialic Acids
This article gives a very short overview on sialic acids and is an excerpt of the introduction from the publication ‘Control of Innate Immunity by Sialic Acids in the Nervous Tissue’ by Liao H, Klaus C, Neumann H. in the Int J Mol Sci. 2020 Jul 31;21(15):E5494. doi: 10.3390/ijms21155494
  • 921
  • 13 Aug 2020
Topic Review
Structure of the North American Beef Industry
North America is a large producer of beef and contains approximately 12% of the world’s cattle inventory. Feedlots are an integral part of modern cattle production in North America, producing a high-quality, wholesome protein food for humans. 
  • 922
  • 09 Mar 2023
Topic Review
Gelidium in Circular Economy Framework
Gelidium corneum (Giant Gelidium or Atlantic agar) is a well-known red seaweed harvested for its high-quality agar content. Agar is a mixture of the polysaccharides used in the food industry as a gelling, thickener, clarifying, and stabilizer agent. The best agar quality is also used in the laboratory as bacteriological agar.
  • 922
  • 06 Jul 2022
Topic Review
Antioxidant
The primary objectives of modern agriculture includes the environmental sustainability, low production costs, improved plants’ resilience to various biotic and abiotic stresses, and high sowing seed value. Delayed and inconsistent field emergence poses a significant threat in the production of agri-crop, especially during drought and adverse weather conditions. To open new routes of nutrients’ acquisition and revolutionizing the adapted solutions, stewardship planswill be needed to address these questions.One approach is the identification of plant based bioactive molecules capable of altering plant metabolism pathways which may enhance plant performance in a brief period of time and in a cost-effective manner.A biostimulant is a plant material, microorganism, or any other organic compound that not only improves the nutritional aspects, vitality, general health but also enhances the seed qualityperformance.
  • 921
  • 07 May 2021
Topic Review
Biomedical Effects of Oregano
The term oregano refers to a group of several plant genera, including Thymbra, Thymus, Coridothymus, Satureja, and Origanum, containing a high amount of the phytochemicals carvacrol and thymol in their essential oils.
  • 921
  • 03 Nov 2021
Topic Review
UFM1
Post-translational modification with Ubiquitin-like proteins represents a complex signaling language regulating virtually every cellular process. Among these post-translational modifiers is Ubiquitin-fold modifier (UFM1), which is covalently attached to its substrates through the orchestrated action of a dedicated enzymatic cascade. Originally identified to be involved embryonic development, its biological function remains enigmatic. Recent research reveals that UFM1 regulates a variety of cellular events ranging from DNA repair to autophagy and ER stress response implicating its involvement in a variety of diseases. Given the contribution of UFM1 to numerous pathologies, the enzymes of the UFM1 cascade represent attractive targets for pharmacological inhibition.
  • 920
  • 26 Feb 2021
Topic Review
Sarcoglycanopathies
Sarcoglycanopathies are autosomal recessive disorders and are considered rare diseases as the worldwide reported frequency is around 1/200,000–1/350,000.
  • 920
  • 03 Jun 2021
Topic Review
Angiotensin II
Cardiovascular disease is the leading cause of morbidity and mortality in the western and developing world, and the incidence of cardiovascular disease is increasing with the longer lifespan afforded by our modern lifestyle.  Vascular diseases including coronary heart disease, high blood pressure, and stroke comprise the majority of cardiovascular disease and therefore represent a significant medical and socioeconomic burden on our society.  It is not be surprising that these conditions overlap and potentiate each other when we consider the many cellular and molecular similarities between them. At the molecular level, the vascular smooth muscle cell (VSMC) is the target, integrator, and effector cell of both atherogenic and the major effector protein of the hypertensive signal, Angiotensin II (Ang II).  Together, these signals can potentiate each other and prime the artery and exacerbate hypertension and atherosclerosis. Therefore, VSMC are the fulcrum in progression of these diseases and therefore, understanding the effects of atherogenic stimuli and Ang II on VSMC is  key to understanding and treating  atherosclerosis and hypertension.  In this review, we will examine studies in which hypertension and atherosclerosis intersect on the VSMC, and illustrate common pathways between these two diseases and vascular aging.
  • 920
  • 07 Jul 2020
Topic Review
Mitochondrial Heteroplasmy and Disease
Given the relevance of mitochondria in numerous physiological and pathological mechanisms, such as adenosine triphosphate (ATP) synthesis, apoptosis, metabolism, cancer progression, and drug resistance, mitochondrial genome (mtDNA) analysis has become of great interest in the study of human diseases, including cancer. A high number of variants and mutations have been identified in different types of tumors, which coexist with normal alleles, a phenomenon named heteroplasmy. This mechanism is considered an intermediate state between the fixation or elimination of the acquired mutations. It is suggested that mutations, which confer adaptive advantages to tumor growth and invasion, are enriched in malignant cells.
  • 921
  • 09 Sep 2022
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