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Topic Review
Biofilm-Forming Ability of Phytopathogenic Bacteria
Phytopathogenic bacteria not only affect crop yield and quality but also the environment. Understanding the mechanisms involved in their survival is essential to develop new strategies to control plant disease. One such mechanism is the formation of biofilms; i.e., microbial communities within a three-dimensional structure that offers adaptive advantages, such as protection against unfavorable environmental conditions. Biofilm-producing phytopathogenic bacteria are difficult to manage. They colonize the intercellular spaces and the vascular system of the host plants and cause a wide range of symptoms such as necrosis, wilting, leaf spots, blight, soft rot, and hyperplasia.
  • 394
  • 08 Jun 2023
Topic Review
Potent Regulators of Cancer Stem Cell Signaling
Cancer stem cells were first identified in breast cancer; it was reported that breast tumors contained heterogeneous populations of cancer cells and that a small population with CD44-positive/high and CD24-negative/low surface expression was capable of generating tumors despite having no obvious morphologic features.
  • 233
  • 08 Jun 2023
Topic Review
Voltage-Gated Calcium Channels for the Treatment of Pain
The voltage-gated calcium channels (VGCCs) are classified in low- (T-type or Cav3) or high-voltage activation (L or Cav1, N, P/Q, and R-type or Cav2). They can be further subclassified by structural similarities (channel-forming α1-subunit) where L-(Cav1.1, Cav1.2, Cav1.3, and Cav1.4), P/Q-(Cav2.1), N-(Cav2.2), and R-(Cav2.3) channels form heteromultimers (along with auxiliary β-, α2δ, and γ-subunits) and T-type (Cav3.1, Cav3.2, and Cav3.3) channels, which are α1-subunit monomers. Pain perception is a sensory and emotionally unpleasant experience; moreover, it represents a huge personal, medical, and economic burden that pharmacotherapy targeting brain pathways is now being researched for and developed in the medical field. Obviously, acute pain does not carry the load of chronic pain that is conceived as a disease on its own and as secondary to an underlying disease (like a symptom). Chronic pain is related to neuronal adaptations and is high risk for psychological distress and sleep deprivation, among other consequences impairing the quality of life. 
  • 404
  • 08 Jun 2023
Topic Review
Fertility Preservation in Transgender Men Patients
Fertility preservation (FP) is becoming a critical issue in transgender men who desire biological offspring in the future. The prevalence of transgender individuals in the United States is increasing, and as a result, the demand for gender-affirming surgeries (GAS) and associated FP techniques is rising.
  • 299
  • 08 Jun 2023
Topic Review Peer Reviewed
Human Power Production and Energy Harvesting
This entry presents a holistic examination of the problem of harvesting energy from the human body. With the advent of the industrial revolution, in modern times, there is less and less need for physical human work; at the same time, motion is essential for health. Thus, sports and physical leisure activities have seen a dramatic increase in popularity. Until several decades ago, energy consumption was not an issue, at least in developed countries, but in recent years, it has become more and more evident that energy resources are finite and that there are limits to how much anthropic pressure the environment can sustain; one evident outcome is global warming. The repurposing of human energy also has psychological benefits, making people socially responsible and transforming otherwise wasted potential into a rewarding activity. Thus, on a small scale, over time, it has become evident that re-using and saving energy are vital. Humans can produce a large amount of energy through physical work, but over the past few decades, technologies have been developed to store and reuse energy that would otherwise be wasted. Some interesting applications and a critical review of the problem, which is linked to human metabolism and sport, are presented.
  • 689
  • 08 Jun 2023
Topic Review
Sustainable Functional Food Ingredients Impact on Gut Microbiota
Food ingredients have different roles and distinct health benefits to the consumer. Over the past years, the interest in functional foods, especially those targeting gut health, has grown significantly. The use of industrial byproducts as a source of new functional and sustainable ingredients as a response to such demands has raised interest. Understanding how newly developed ingredients from undervalued agro-industrial sources behave and modulate the gut microbiota, supports the development of new and more sustainable functional foods while scientifically backing up health-benefits claims.
  • 415
  • 08 Jun 2023
Topic Review
Adoption in Archaeological Human Remains
Adoption appears in different moments of past societies. When establishing a “family” nucleus burial place, it is must be considered certain social behaviors, such as burials under the houses, collective burials, or laying bodies in specific positions.
  • 413
  • 07 Jun 2023
Topic Review
Mass Spectrometry-Based Lipidomic Technologies
Lipids play important biological roles, such as providing essential fatty acids and signaling. The wide variety and structural diversity of lipids, and the limited technical means to study them, have seriously hampered the resolution of the mechanisms of action of lipids. With advances in mass spectrometry (MS) and bioinformatic technologies, large amounts of lipids have been detected and analyzed quickly using MS-based lipidomic techniques. Milk lipids, as complex structural metabolites, play a crucial role in human health. 
  • 247
  • 07 Jun 2023
Topic Review
Vegetable Beverages from Carob, Tiger Nut and Rice
Rice, tiger nut and carob are Mediterranean products suitable for developing new foods, such as fermented beverages, due to their nutritional properties. These crops have a high carbohydrate content, are gluten and lactose-free and have a low allergenicity index. The development of fermented beverages from these crops can contribute to the Sustainable Development Goals by promoting human health and sustainable production and consumption.
  • 608
  • 07 Jun 2023
Topic Review
Identification Methods of Entomological Origin of Honey
Honey is a sweet natural product that is produced by managed and wild bees, derived from the nectar of flowers. It is made up of various components such as sugar, protein, vitamins, minerals, aromatic substances, polyphenols, pigments, beeswax, and pollen that contribute to its color, smell, and flavor. However, honey adulteration is a growing concern, including the production of honey by feeding bees with commercial industrial sugar, the addition of foreign sugar, as well as mislabeling. Therefore, traceability of the entomological origin of honey should also be considered in honey quality control protocols. Although several methods exist, such as physicochemical characterization and bioactivity profiling of honey of different entomological origins, the most promising three methods for entomological authentication of honey include protein-based identification, chemical profiling, and a DNA-based method. ll of these methods can be applied for reliable identification of the entomological origin of honey. However, as the honey is a complex matrix, the inconsistency of the results obtained by these methods is a pragmatic challenge, and therefore, the use of each method in all the cases is questionable. Most of these methodologies can be used for authentication of newly harvested honey and it is worth understanding the possibility of using these methods for authentication of relatively old samples. Most probably, using DNA-based methods targeting small fragments of DNA can provide the best result in old samples, however, the species-specific primers targeting short fragments are limited and not available for all species. Therefore, using universal primers in combination with a DNA metabarcoding approach can be a good solution that requires further investigation.
  • 489
  • 07 Jun 2023
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