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Topic Review
Oxidative Stress in NAFLD
Oxidative stress is defined as an imbalance between the cellular levels of antioxidants and that of pro-oxidants, including ROS and reactive nitrogen species, which causes cellular damage and, in most cases, cell death. Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic syndrome and its comorbidities that comprise, among others, obesity and insulin-resistance. At the molecular level, several models have been proposed for the pathogenesis of NAFLD. Most importantly, oxidative stress and mitochondrialdamage have been reported to be causative in NAFLD initiation and progression.
  • 1.0K
  • 02 Aug 2021
Biography
Edip Yüksel
Edip Yüksel (born December 20, 1957 in Güroymak, Turkey) is a Kurdish American author and philosophy professor of Sunni Muslim background. He is an exponent of the modern Islamic reform and Quranism (Quraniyoon) movements and is known for his criticism and rejection of both Sunni and Shiite versions of Islam. Author of several books on the Qur'an and Islam, he gained attention through his work
  • 1.0K
  • 01 Dec 2022
Topic Review
Redox Homeostasis in Muscular Dystrophies
Reactive oxygen species are (ROS) are signaling molecules moderately and continuously produced by skeletal muscles as a consequence of their contractile activity and high mitochondrial oxygen consumption. The main source of ROS production is located in the cytosol through the activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX enzymes), xanthine oxidase (XO), and nitric oxide synthase (NOS), and by the mitochondrial electron transport chain. When ROS exceed the antioxidant buffering capacity of tissues, oxidative stress occurs.
  • 1.0K
  • 15 Jun 2021
Topic Review
Fungal Enzymes Involved in Plastics Biodegradation
Plastic pollution is a growing environmental problem, in part due to the extremely stable and durable nature of this polymer. As recycling does not provide a complete solution, research has been focusing on alternative ways of degrading plastic. Fungi provide a wide array of enzymes specialized in the degradation of recalcitrant substances and are very promising candidates in the field of plastic degradation.
  • 1.0K
  • 08 Jul 2022
Topic Review
Organic winemaking and its subsets
The wine industry has evolved over time, and more so recently, to encompass many different subsets, one of which is the organic wine market. The organic wine industry has grown in recent years, especially in California. This rapid gain in interest has resulted in the evolution of several subsets, including biodynamic, natural, and clean wine. While biody-namic and natural wine, function more as a fulfillment of niche markets, clean wine may provide benefits for consumers that otherwise suffer from side effects of wine consumption. Low sulfite levels and lack of histamines in clean wine plausibly decrease headaches and adverse effects some consumers experience when drinking wine.
  • 1.0K
  • 21 Jan 2021
Topic Review
Pancreatic Cancer Organ-Chip Models
Pancreatic Ductal Adenocarcinoma (PDAC) is an expeditiously fatal malignancy with a five-year survival rate of 6–8%. Conventional chemotherapeutics fail in many cases due to inadequate primary response and rapidly developing resistance. This treatment failure is particularly challenging in pancreatic cancer because of the high molecular heterogeneity across tumors. Additionally, a rich fibro-inflammatory component within the tumor microenvironment (TME) limits the delivery and effectiveness of anticancer drugs, further contributing to the lack of response or developing resistance to conventional approaches in this cancer. Patient-derived three-dimensional (3D) organoid technology has provided a unique opportunity to study patient-specific cancerous epithelium. Patient-derived organoids cultured with the TME components can more accurately reflect the in vivo tumor environment. A number of in vitro models have been developed to address the limitation of the lack of tumor extracellular matrix (ECM) in the conventional models of cancer and drug screening platforms. In this regard, microfluidic chips are cutting-edge devices that process fluids in micro-sized channels and allow the culture of multiple cell types within a matrix—so-called ‘organ-on-a-chip (OOC)’ technology. OOC allows us to recapitulate 3D multicellular architecture and microengineering of TME with the potential to bridge the gaps between bench and bedside by providing screening platforms for testing anticancer agents before reaching human clinical trials.
  • 1.0K
  • 19 Oct 2021
Topic Review
Sphingolipids and DNA Damage Response
Sphingolipids are essential structural components of biological membranes that mediate a wide array of physiological functions such as inflammation, cell proliferation, survival, senescence, and death. An emerging body of evidence suggests that bioactive sphingolipids modulate the DNA damage response (DDR) induced by genotoxic stress and therein determine cell fate.
  • 1.0K
  • 16 Jul 2020
Topic Review
Fibroblasts
Fibroblasts, the most abundant cells in the connective tissue, are key modulators of the extracellular matrix (ECM) composition.
  • 1.0K
  • 18 Jan 2021
Topic Review
Vitamin D-dependent Rickets
Vitamin D-dependent rickets is a disorder of bone development that leads to softening and weakening of the bones (rickets).
  • 1.0K
  • 23 Dec 2020
Topic Review
Actinobacteria and Environmental Adaptations
Actinobacteria are among the secondary metabolites producers and hold high pharmacological and commercial interest. It has great capability to produce secondary metabolites such as immunomodulators, antibiotics, anti-cancer drugs, growth factors, anthelminthic enzymes and herbicides.describes the historical isolation of bioactive compounds from Actinobacteria from the first isolation by Selman Waksman.
  • 1.0K
  • 05 Aug 2021
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