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Topic Review
Multi-Micronutrients Deficiency in Agricultural Soils
The deficiencies of nutrient elements and inappropriate nutrient management practices in agricultural soils of the world is one of the reasons for low crop productivity, reduced nutritional quality of agricultural produce, and animal/human malnutrition.
  • 1.1K
  • 06 Sep 2021
Topic Review
Diabetic Complications: Oxidative Stress/Inflammation
Oxidative stress and inflammation are considered major drivers in the pathogenesis of diabetic complications, including renal and cardiovascular disease. A symbiotic relationship also appears to exist between oxidative stress and inflammation. Several emerging therapies target these crucial pathways, to alleviate the burden of the aforementioned diseases. Oxidative stress refers to an imbalance between reactive oxygen species (ROS) and antioxidant defenses, a pathological state which not only leads to direct cellular damage but also an inflammatory cascade that further perpetuates tissue injury. Emerging therapeutic strategies tackle these pathways in a variety of ways, from increasing antioxidant defenses (antioxidants and Nrf2 activators) to reducing ROS production (NADPH oxidase inhibitors and XO inhibitors) or inhibiting the associated inflamma-tory pathways (NLRP3 inflammasome inhibitors, lipoxins, GLP-1 receptor agonists, and AT-1 re-ceptor antagonists).
  • 1.1K
  • 14 Jan 2021
Topic Review
Exosome Treatment for Hearing Loss
There are reported types of hearing loss includes noise-induced, genetic, sudden, ototoxicity, and age-related hearing loss. The application of exosomes for prevention or treatment can be classified according to the type of hearing loss, suggesting that they may help restore abnormalities in chemical and biological mechanism. The fundamental recovery of inner hair cells by exosome is difficult, because both noise-induced and sudden hearing loss occur due to physical stimulation of hair cell death.
  • 1.1K
  • 11 Oct 2021
Topic Review
Quiescent Cancer Cells
Quiescent cancer cells (QCCs) are cancer cells that are reversibly suspended in G0 phase with the ability to re-enter the cell cycle and initiate tumor growth, and, ultimately, cancer recurrence and metastasis.
  • 1.1K
  • 23 Mar 2021
Topic Review Peer Reviewed
β-Glucans
β-glucans are complex polysaccharides that are found in several plants and foods, including mushrooms. β-glucans display an array of potentially therapeutic properties.
  • 1.1K
  • 13 Apr 2022
Topic Review
Biological Activity of Cinnamomum Camphora Essential Oils
Camphor tree (Cinnamomum camphora) is an ornamental plant that has been cultivated for a long time to obtain wood or camphor. Furthermore, its essential oil can be used as an alternative medicine and is an important source of perfume. Camphor obtained from camphor trees has long been used as a treatment for various symptoms such as inflammation, infection, congestion, muscle pain, and irritation in various regions. Despite many studies focused on the essential oil of the camphor tree, there is a lack of systematic studies of its extraction or separation. Besides, various components of camphor are not fully understood, and further research is needed on the medicinal effects of individual components of C. camphor. The genus Cinnamomum has crucial economic value and theoretical significance.
  • 1.1K
  • 28 Jun 2022
Topic Review
Nucleosides and Nucleotides
Nucleotides fulfill many essential functions in plants. Compared to non-plant systems, these hydrophilic metabolites have not been adequately investigated in plants, especially the less abundant nucleotide species such as deoxyribonucleotides and modified or damaged nucleotides. Until recently, this was mainly due to a lack of adequate methods for in-depth analysis of nucleotides and nucleosides in plants.
  • 1.1K
  • 16 Apr 2021
Topic Review
Sanfilippo Syndrome
Sanfilippo syndrome is caused by mutations in the enzymes responsible for the degradation of heparan sulfate (HS), a specific GAG, and patients are characterized by severe neurological pathology leading to childhood dementia.
  • 1.1K
  • 17 Nov 2020
Topic Review
The Role of Polyploidy in the Human Body
Somatic polyploidy was found in the tissues of all multicellular organisms (including algae, mosses, lichens, vascular plants, invertebrates, and vertebrates), which points to its adaptive value. In human and warm-blooded animals, polyploidy can be a part of normal postnatal morphogenetic programs and can be a manifestation of response to pathological stimuli and diseases.
  • 1.1K
  • 11 Apr 2022
Topic Review
MitoQ
Mitoquinone (MitoQ) is a mitochondrial reactive oxygen species scavenger that is characterized by high bioavailability. Prior studies have demonstrated its neuroprotective potential. Indeed, the release of reactive oxygen species due to damage to mitochondrial components plays a pivotal role in the pathogenesis of several neurodegenerative diseases.
  • 1.1K
  • 11 May 2021
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