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Topic Review
Essential Oils for Food Packaging
Essential oils (EOs) are concentrated liquid mixtures of volatile compounds with antioxidant and antibacterial properties that can be used as natural, eco-friendly, renewable, and cost-effective additives. The use of combinations of different EOs and their components is a promising strategy to increase the synergistic and additive effects of EOs in foods.
  • 1.2K
  • 27 Sep 2021
Topic Review
Level of Consciousness (Esotericism)
Consciousness is a loosely defined concept that addresses the human awareness of both internal and external stimuli. This can refer to spiritual recognition, psychological understanding, medically altered states, or more modern-day concepts of life purpose, satisfaction, and self-actualization. Levels of Consciousness can be presented in a map. Some levels are more continuous or complex than others. Movement between levels or stages is often bidirectional depending on internal and external conditions, with each mental ascension precipitating a change in reactivity. In the most basic sense, this alteration might lead to a reduced responsiveness as seen in anesthesiology; more abstract facets of tiered consciousness describe characteristics of profoundness, insight, perception, or understanding. First appearing in the historical records of the ancient Mayan and Incan civilizations, proposals of multiple levels of consciousness have pervaded spiritual, psychological, medical, and moral speculations in both Eastern and Western cultures. Because of occasional and sometimes substantial overlap between hypotheses, there have recently been attempts to combine perspectives to form new models that integrate components of separate viewpoints. Any of these proposals, models or viewpoints can be verified or falsified, and are open to question.
  • 1.2K
  • 24 Nov 2022
Topic Review
SARS-CoV-2 Main Protease
The main protease (Mpro) of the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was subjected to hyphenated pharmacophoric-based and structural-based virtual screenings using a library of microbial natural products (>24,000 compounds). Subsequent filtering of the resulted hits according to Lipinski’s rules was applied to select only the drug-like molecules. Top-scoring hits were further filtered out depending on their ability to show constant good binding affinities towards the molecular dynamic simulation (MDS)-derived enzyme’s conformers. Final MDS experiments were performed on the ligand-protein complexes to verify their binding modes and calculate their binding free energy. Consequently, a final selection of six compounds of microbial origin was proposed to possess high potential as anti-SARS-CoV-2 drug candidates. Our study provides insight into the role of the Mpro structural flexibility during interactions with the possible inhibitors and sheds light on the structure-based design of anti-coronavirus disease 2019 (COVID-19) therapeutics targeting SARS-CoV-2
  • 1.2K
  • 26 Oct 2020
Topic Review
Salicylic Acid in Root Growth and Development
In plants, salicylic acid (SA) is a hormone that mediates a plant’s defense against pathogens. SA also takes an active role in a plant’s response to various abiotic stresses, including chilling, drought, salinity, and heavy metals. In addition, in recent years, numerous studies have confirmed the important role of SA in plant morphogenesis.
  • 1.2K
  • 10 Mar 2022
Topic Review
Drought Stress
Drought is one of the most important factors restricting agricultural production, which seriously affects crop yield.
  • 1.2K
  • 18 May 2021
Topic Review
Viral Equine Encephalitis
Neurological disorders represent an important sanitary and economic threat for the equine industry worldwide. Among nervous diseases, viral encephalitis is of growing concern, due to the emergence of arboviruses and to the high contagiosity of herpesvirus-infected horses. The nature, severity and duration of the clinical signs could be different depending on the etiological agent and its virulence. However, definite diagnosis generally requires the implementation of combinations of direct and/or indirect screening assays in specialized laboratories. The equine practitioner, involved in a mission of prevention and surveillance, plays an important role in the clinical diagnosis of viral encephalitis. The general management of the horse is essentially supportive, focused on controlling pain and inflammation within the central nervous system, preventing injuries and providing supportive care. Despite its high medical relevance and economic impact in the equine industry, vaccines are not always available and there is no specific antiviral therapy. In this review, the major virological, clinical and epidemiological features of the main neuropathogenic viruses inducing encephalitis in equids in Europe, including rabies virus (Rhabdoviridae), Equid herpesviruses (Herpesviridae), Borna disease virus (Bornaviridae) and West Nile virus (Flaviviridae), as well as exotic viruses, will be presented.
  • 1.2K
  • 29 Oct 2020
Topic Review
Type 2 Diabetes Mellitus
Uncontrolled Type 2 diabetes is associated with altered metabolism resulting in microvascular and macrovascular diseases and enhanced susceptibility to Mycobacterium tuberculosis infection.
  • 1.2K
  • 31 Jul 2020
Topic Review
Oil Palm and Machine Learning
Machine learning (ML) offers new technologies in the precision agriculture domain with its intelligent algorithms and strong computation. Oil palm is one of the rich crops that is also emerging with modern technologies to meet global sustainability standards. This entry presents a comprehensive review of research dedicated to the application of ML in the oil palm agricultural industry over the last decade (2011–2020).
  • 1.2K
  • 16 Sep 2021
Topic Review
Updated Understanding of Cancer
       Cancer is a tumorigenesis process that forms a mass of cells that we call a tumor. During tumorigenesis, the cells that compose the tumor can be benign or malignant. When the cells in the tumor are normal but old, the tumor is termed benign. When the cells in the tumor are abnormal and can grow uncontrollably, the tumor is malignant. Sometimes a benign tumor can transform into a malign one if the normal old cells begin to develop abnormalities, such as DNA mutations, and grow rapidly. - by Cristian Muresanu
  • 1.2K
  • 30 Oct 2020
Topic Review
Uremic Toxins
Some uremic toxins such as indol acetic acid, indoxyl sulfate, p-cresyl sulfate hippuric acid, phenyl sulfate, trimethylamine N-oxide, and hydrogen sulfide in the blood of CKD patients come from the metabolism of bacteria in the gut. As a result of the conducted research, the list of potential uremic toxins is constantly being modified. For example, it is suggested that the current list of cytokines that are considered potential uremic toxins is incomplete and excessive.
  • 1.2K
  • 28 Jun 2021
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