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Topic Review
Overcoming Antibody Escaped Mutations Based SARS-CoV-2 Waves
 ACE2 coupling, and the S protein cleavage site, as targets for the development of nano-enabled solutions that, for example, prevent viral attachment and fusion with the host cell by either blocking viral RBD/spike proteins or cellular ACE2 receptors.
  • 267
  • 06 Sep 2023
Topic Review
MAP Intercropping in the Mediterranean Basin
The Mediterranean basin (MB), a “climate hotspot”, is experiencing faster than average increases in global temperature and water deficit, as well as soil degradation, with detrimental impacts on food crop yield and pest/pathogen incidence. Hence, there is an urgent requisite for sustainable crop diversification strategies to promote crop resilience, soil quality conservation and pest/pathogen control. Intercropping is a strategy that has yet to be widely adopted. Presently, cereal–legume combinations represent the most common intercrops. Of relevance, a large number of medicinal and aromatic plants (MAPs), native to the MB, serve as potentially profitable indigenous resources for intercropping with food crops. Environmentally sustainable benefits of MB MAP intercropping with food crops have ironically been reported largely from research outside the MB.
  • 332
  • 06 Sep 2023
Topic Review
Fluorescent Probes in Heavy Metal Determinations for Food
Among the current detection methods, technology based on fluorescent probes, with the advantages of sensitivity, convenience, accuracy, cost, and reliability, has recently shown pluralistic applications in the food industry, which is significant to ensure food safety.
  • 335
  • 06 Sep 2023
Topic Review
Significance of Skin Microbiota for Wound Healing
Wounded skin can naturally be repaired by a mechanism called wound healing. Human skin is a habitat of various pathogenic and commensal bacteria. While these bacteria are in balance in healthy skin, they can lose the balance by wounding, which leads to delay in the wound-healing process. Moreover, commensal and pathogenic bacteria inhabit skin tissue and have constant communication with the immune system, which can increase and decrease the healing efficiency, respectively.
  • 183
  • 06 Sep 2023
Topic Review
Parkinson Disease
Parkinson disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.
  • 818
  • 06 Sep 2023
Topic Review
Dopamine Levels and Metabolism in the Heart
Dopamine has effects on the mammalian heart. These effects can include an increase in the force of contraction, and an elevation of the beating rate and the constriction of coronary arteries. Depending on the species studied, positive inotropic effects were strong, very modest, or absent, or even negative inotropic effects occurred.
  • 256
  • 06 Sep 2023
Topic Review
Retrotransposons in Cancer
Retrotransposons, which move from one genomic site to another by a copy-and-paste mechanism, are regulated by various molecular pathways that may be disrupted during tumorigenesis. Active retrotransposons can stimulate type I IFN responses. Although accumulated evidence suggests that retrotransposons can induce inflammation, the research investigating the exact mechanism of triggering these responses is ongoing.
  • 221
  • 06 Sep 2023
Topic Review
Action of lncRNAs Mediated by RBPs in NSCLC
LncRNAs can alter gene expression and/or its functions by acting as miRNA spongers, via a direct interaction of lncRNAs with mRNAs or binding to RNA-binding proteins (RBPs). RBPs were shown to regulate mRNA expression and stability at the post-transcriptional level. RBPs combine a flexible structure with a versatile RNA-binding domain. These properties allow RBPs to engage in highly dynamic interactions both with other proteins as well as with coding and non-coding RNAs, leading to ribonucleoprotein complexes (RNPs) being formed. RNPs regulate RNA splicing, polyadenylation, stability, localization, translation, and degradation. In non-small-cell lung cancer (NSCLC), lncRNAs can regulate the levels and stability of target mRNAs by binding RBPs to form RNP complexes, as was demonstrated in a number of examples.
  • 172
  • 06 Sep 2023
Topic Review
Glucagon and Its Receptors in the Mammalian Heart
Glucagon exerts effects on the mammalian heart. These effects include alterations in the force of contraction, beating rate, and changes in the cardiac conduction system axis. The cardiac effects of glucagon vary according to species, region, age, and concomitant disease. Depending on the species and region studied, the contractile effects of glucagon can be robust, modest, or even absent. Glucagon is detected in the mammalian heart and might act with an autocrine or paracrine effect on the cardiac glucagon receptors. The glucagon levels in the blood and glucagon receptor levels in the heart can change with disease or simultaneous drug application. 
  • 215
  • 06 Sep 2023
Topic Review
Animal Model of Endometriosis
Endometriosis, a common gynecological disorder affecting around 10% of reproductive-age women, involves the growth of uterine tissue outside the uterus. Despite its long recognition, its underlying causes remain poorly understood. To study this complex condition, researchers have turned to animal models, particularly laboratory mice. These models, while cost-effective and genetically controllable, have limitations due to differences between mouse and human physiology, necessitating artificial induction of endometriosis. Innovative approaches, such as "fluorescent murine models," aid lesion identification and response assessment. Additionally, heterologous murine models involving human tissue transplantation offer insights but have their own limitations. Despite challenges, these models contribute significantly to endometriosis research, paving the way for potential treatments.
  • 216
  • 05 Sep 2023
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