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Topic Review
Pathophysiology of Pulmonary Fibrosis
Pulmonary fibrosis (PF) is a feared outcome of many pulmonary diseases which results in a reduction in lung compliance and capacity. The development of PF is relatively rare, but it can occur secondary to viral pneumonia, especially COVID-19 infection. While COVID-19 infection and its complications are still under investigation, researchers can look at a similar outbreak in the past to gain better insight as to the expected long-term outcomes of COVID-19 patient lung function.
  • 1.4K
  • 24 Aug 2022
Topic Review
Functional Mechanisms of Coding and Non-Coding Region SNPs
Cancer ranks as the second leading cause of death worldwide, and, being a genetic disease, it is highly heritable. Over the past few decades, genome-wide association studies (GWAS) have identified many risk-associated loci harboring hundreds of single nucleotide polymorphisms (SNPs). Some of these cancer-associated SNPs have been revealed as causal, and the functional characterization of the mechanisms underlying the cancer risk association has been illuminated in some instances.
  • 1.4K
  • 12 Dec 2022
Topic Review
Plant Stress Detection by Thermography
Leaf and canopy temperature is a valuable indicator of the physiological status of plants, responding to both biotic and abiotic stressors. Thermography, often combined with other imaging sensors and data-mining techniques, is crucial in the implementation of a more automatized, precise and sustainable agriculture.
  • 1.4K
  • 25 Jan 2021
Topic Review
Zeaxanthin and Photoprotection in Plants
Conversion of sunlight into photochemistry by plants depends on photoprotective processes that allow safe use of sunlight over a broad range of environmental conditions. This entry focuses on the universal use by plants of the photoprotector zeaxanthin that is part of a group of three interconvertible leaf carotenoids collectively known as the xanthophyll cycle. We survey the striking plasticity of this photoprotective process in nature that can be fine-tuned to produce a fit for different environments with various combinations of light, temperature, and other factors.
  • 1.4K
  • 25 Dec 2020
Topic Review
CD44 Receptor
CD44 is a receptor described as a single span transmembrane glycoprotein without kinase activity whose ubiquitous and constitutive expression has been observed on many different cells.
  • 1.4K
  • 18 Mar 2021
Topic Review
Baddeley's Model of Working Memory
Baddeley's model of working memory is a model of human memory proposed by Alan Baddeley and Graham Hitch in 1974, in an attempt to present a more accurate model of primary memory (often referred to as short-term memory). Working memory splits primary memory into multiple components, rather than considering it to be a single, unified construct. Baddeley & Hitch proposed their three-part working memory model as an alternative to the short-term store in Atkinson & Shiffrin's 'multi-store' memory model (1968). This model is later expanded upon by Baddeley and other co-workers to add a fourth component, and has become the dominant view in the field of working memory. However, alternative models are developing, providing a different perspective on the working memory system. The original model of Baddeley & Hitch was composed of three main components: the central executive which acts as a supervisory system and controls the flow of information from and to its slave systems: the phonological loop and the visuo-spatial sketchpad. The phonological loop stores verbal content, whereas the visuo-spatial sketchpad caters to visuo-spatial data. Both the slave systems only function as short-term storage centers. In 2000, Baddeley added a third slave system to his model, the episodic buffer. Baddeley & Hitch's argument for the distinction of two domain-specific slave systems in the older model was derived from experimental findings with dual-task paradigms. Performance of two simultaneous tasks requiring the use of two separate perceptual domains (i.e. a visual and a verbal task) is nearly as efficient as performance of the tasks individually. In contrast, when a person tries to carry out two tasks simultaneously that use the same perceptual domain, performance is less efficient than when performing the tasks individually. A fourth component of Baddeley's model was added 25 years later to complement the central executive system. The third slave system was designated as episodic buffer. It is considered a limited-capacity system that provides temporary storage of information by conjoining information from the subsidiary systems, and long-term memory, into a single episodic representation.
  • 1.4K
  • 04 Nov 2022
Topic Review
Entompathogen Wasps
Parasitoid wasps inject eggs into the host insect along with several factors that modulate the immune response, in addition these molecular structures and compounds, present at the surface of the gamete, contribute to the evasive and depressive strategies of the parasitoid by facilitating the development of eggs and larvae within the host body.
  • 1.4K
  • 09 Nov 2020
Topic Review
Chitosan Biopolymer on Plant Growth
The chitosan (CHT) biopolymer is a de-acetylated chitin derivative derived from the outer shell of shrimp, shellfish, lobster, or crabs, as well as the cell wall of fungi. Because of its biodegradability, environmental non-toxicity, and biocompatibility, it is an ideal resource for sustainable agriculture. The CHT emerged as a promising agent used as a plant growth promoter. It induces plant growth by influencing plant physiological processes like nutrient uptake, cell division, cell elongation, enzymatic activation, and synthesis of protein that can eventually lead to increased yield. It also alters plant defense responses by triggering multiple useful metabolic pathways. Depending on the structures, chitosan is useful for industrial and agricultural applications.
  • 1.4K
  • 21 Dec 2020
Topic Review
3D-LC
Three-dimensional liquid chromatography (3D-LC) is the consecutive combination of 3 independent LC techniques to decrease the complexity of proteome digest samples. 3D-LC systems can be performed in an online or offline manner. Ideally, each dimension in a 3D-LC system is completely orthogonal to the others.
  • 1.4K
  • 27 Oct 2020
Topic Review
Fabrication of Organ-on-Chip
Organ-on-chips (OOCs) are microfluidic devices used for creating physiological organ biomimetic systems. OOC technology brings numerous advantages in the current landscape of preclinical models, capable of recapitulating the multicellular assemblage, tissue–tissue interaction, and replicating numerous human pathologies.
  • 1.4K
  • 26 Apr 2022
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