Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
Heat Shock Proteins Immunostimulatory Properties-based Cancer Immunotherapy
The development of multidrug resistance (MDR) against chemotherapeutic agents has become a major impediment in cancer therapy. Understanding the underlying mechanism behind MDR can guide future treatment for cancer with better therapeutic outcomes. Recent studies evidenced that crossroads interaction between the heat shock proteins (HSP) and inflammatory responses under the tumor microenvironment plays a pivotal role in modulating drug responsiveness and drug resistance through a complex cytological process.
  • 550
  • 26 Oct 2023
Topic Review
Smart Irrigation for Improving Water Productivity in Drylands
By using several factors, including soil and climate variation, soil properties, plant responses to water deficits, and changes in weather factors, smart irrigation can drive better irrigation decisions that can help save water and increase yields. Various smart irrigation approaches, such as artificial intelligence and deep learning (artificial neural network, fuzzy logic, expert system, hybrid intelligent system, and deep learning), model predictive irrigation systems, variable rate irrigation (VRI) technology, and unmanned aerial vehicles (UAVs) could ensure high water use efficiency in water-scarce regions. These smart irrigation technologies can improve water management and accelerate the progress in achieving multiple Sustainable Development Goals (SDGs), where no one gets left behind.
  • 371
  • 26 Oct 2023
Topic Review
SLC9B2 (NHA2/NHEDC2) in Male Fertility
The SLC9B2 gene encodes the NHA2 protein (also known as NHEDC2). While NHA2 has been shown to be important for regulating various aspects of physiology such as blood pressure, this protein has also been implicated as being important for male fertility in mice. What is known about NHA2 and its potentially important role in male fertility is emphasized.
  • 314
  • 26 Oct 2023
Topic Review
Retrovirus-Derived RTL/SIRH Genes in Eutherian Developmental System
Eutherians have 11 retrotransposon Gag-like (RTL)/sushi-ichi retrotransposon homolog (SIRH) genes presumably derived from a certain retrovirus. Accumulating evidence indicates that the RTL/SIRH genes play a variety of roles in the mammalian developmental system, such as in the placenta, brain, and innate immune system, in a eutherian-specific manner. It has been shown that the functional role of Paternally Expressed 10 (PEG10) in placental formation is unique to the therian mammals, as are the eutherian-specific roles of PEG10 and PEG11/RTL1 in maintaining the fetal capillary network and the endocrine regulation of RTL7/SIRH7 (aka Leucine Zipper Down-Regulated in Cancer 1 (LDOCK1)) in the placenta. In the brain, PEG11/RTL1 is expressed in the corticospinal tract and hippocampal commissure, mammalian-specific structures, and in the corpus callosum, a eutherian-specific structure. Unexpectedly, at least three RTL/SIRH genes, RTL5/SIRH8, RTL6/SIRH3, and RTL9/SIRH10, play important roles in combating a variety of pathogens, namely viruses, bacteria, and fungi, respectively, suggesting that the innate immunity system of the brain in eutherians has been enhanced by the emergence of these new components. 
  • 294
  • 25 Oct 2023
Topic Review
Primary Neurological Disease Absence in Hutchinson–Gilford Progeria Syndrome
Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder caused by the mutant protein progerin, which is expressed by the abnormal splicing of the LMNA gene. HGPS affects systemic levels, with the exception of cognition or brain development, in children, showing that cellular aging can occur in the short term.
  • 232
  • 25 Oct 2023
Topic Review
Metabolism of Acetic Acid Bacteria
Vinegar is one of the most appreciated fermented foods in European and Asian countries. In industry, its elaboration depends on numerous factors, including the nature of starter culture and raw material, as well as the production system and operational conditions. Furthermore, vinegar is obtained by the action of acetic acid bacteria (AAB) on an alcoholic medium in which ethanol is transformed into acetic acid. Besides the highlighted oxidative metabolism of AAB, their versatility and metabolic adaptability make them a taxonomic group with several biotechnological uses.
  • 458
  • 25 Oct 2023
Topic Review
The Mediterranean Diet
A cornerstone of any healthy lifestyle program is the inclusion of a balanced diet that can prevent various diseases, including cardiovascular conditions. The Mediterranean diet (MD) has become one of the most studied and widely reported diets and has received a lot of attention. The MD is a dietary plan based on Crete’s traditional eating habits. 
  • 335
  • 25 Oct 2023
Topic Review
Candidate Proteome-Based Biomarkers for Alzheimer’s Disease
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline and memory loss. Early and accurate diagnosis of AD is crucial for implementing timely interventions and developing effective therapeutic strategies. Proteome-based biomarkers have emerged as promising tools for AD diagnosis and prognosis due to their ability to reflect disease-specific molecular alterations. 
  • 327
  • 25 Oct 2023
Topic Review
Probiotics and Probiotic-like Agents against Chemotherapy-Induced Intestinal Mucositis
Cancer chemotherapy has allowed many patients to survive, but not without risks derived from its adverse effects. Drugs, such as 5-fluorouracil, irinotecan, oxaliplatin, methotrexate, and others, as well as different drug combinations trigger intestinal mucositis that may cause or contribute to anorexia, pain, diarrhea, weight loss, systemic infections, and even death. Dysbiosis is a hallmark of chemotherapy-induced intestinal mucositis and diarrhea, and, therefore, strategies aimed at modulating intestinal microbiota may be useful to counteract and prevent those dreadful effects.
  • 504
  • 25 Oct 2023
Topic Review
Navigating the ERK1/2 MAPK Cascade
The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological processes including proliferation, cell cycle control, growth, and survival; common across all cell types. Notably, ERK1/2 are implicated in specific processes in a context-dependent manner as in stem cells and pancreatic β-cells. Alterations in the different components of this cascade result in dysregulation of the effector kinases ERK1/2 which communicate with hundreds of substrates. Aberrant activation of the pathway contributes to a range of disorders, including cancer.
  • 770
  • 25 Oct 2023
  • Page
  • of
  • 1815
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
ScholarVision Creations
Feedback