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Topic Review
Symbiotic Bacillota (Firmicutes) of Marine Macroalgae
The shift from the terrestrial to the marine environment to discover natural products has given rise to novel bioactive compounds, some of which have been approved for human medicine. However, the ocean, which makes up nearly three-quarters of the Earth’s surface, contains macro- and microorganisms whose natural products are yet to be explored. Among these underexplored marine organisms are macroalgae and their symbiotic microbes, such as Bacillota, a phylum of mostly Gram-positive bacteria previously known as Firmicutes. Macroalgae-associated Bacillota often produce chemical compounds that protect them and their hosts from competitive and harmful rivals.
  • 327
  • 13 Nov 2023
Topic Review
Properties of the DNA Damage Response Mre11/Rad50 Complex
DNA double-strand breaks (DSBs) are a significant threat to cell viability due to the induction of genome instability and the potential loss of genetic information. One of the key players for early DNA damage response is the conserved Mre11/Rad50 Nbs1/Xrs2 (MRN/X) complex, which is quickly recruited to the DNA ruptured ends and is required for their tethering and their subsequent repair via different pathways. The MRN/X complex associates with several other proteins to exert its functions, but it also exploits sophisticated internal dynamic properties to orchestrate the several steps required to address the damage. 
  • 188
  • 13 Nov 2023
Topic Review
Nepetoideae
Nepetoideae is the most diverse subfamily of Lamiaceae, and some species are well known for their culinary and medicinal uses. In recent years, there has been growing interest in the therapeutic properties of the species of this group regarding inflammatory illnesses.
  • 351
  • 13 Nov 2023
Topic Review
Models of Protective Immunity against Schistosomes
A schistosome vaccine still looks to be a distant prospect. These helminths can live in the human bloodstream for years, even decades, surrounded by and feeding on the components of the immune response they provoke. The original idea of a vaccine based on the killing of invading cercariae in the skin has proven to be illusory. There has also been a realisation that even if humans develop some protection against infection over a protracted period, it very likely involves IgE-mediated responses that cannot provide the basis for a vaccine. However, it has also become clear that both invasive migrating larvae and adult worms must expose proteins and release secretions into the host environment as part of their normal biological activities. These antigens are now the focus of current vaccine developments.
  • 253
  • 13 Nov 2023
Topic Review
Innovative Phospholipid Carriers versus Antimicrobial Resistance
The overuse and misuse of antibiotics have led to the emergence and spread of multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria strains, usually associated with poorer patient outcomes and higher costs. In order to preserve the usefulness of these life-saving drugs, it is crucial to use them appropriately, as also recommended by the WHO. Moreover, innovative, safe, and more effective approaches are being investigated, aiming to revise drug treatments to improve their pharmacokinetics and distribution and to reduce the onset of drug resistance. Globally, to reduce the burden of antimicrobial resistance (AMR), guidelines and indications have been developed over time, aimed at narrowing the use and diminishing the environmental spread of these life-saving molecules by optimizing prescriptions, dosage, and times of use, as well as investing resources into obtaining innovative formulations with better pharmacokinetics, pharmacodynamics, and therapeutic results. This has led to the development of new nano-formulations as drug delivery vehicles, characterized by unique structural properties, biocompatible natures, and targeted activities such as state-of-the-art phospholipid particles generally grouped as liposomes, virosomes, and functionalized exosomes, which represent an attractive and innovative delivery approach.
  • 226
  • 13 Nov 2023
Topic Review
REST/NRSF in Health and Disease
Chromatin modifications play a crucial role in the regulation of gene expression. The repressor element-1 (RE1) silencing transcription factor (REST), also known as neuron-restrictive silencer factor (NRSF) and X2 box repressor (XBR), was found to regulate gene transcription by binding to chromatin and recruiting chromatin-modifying enzymes. Earlier studies revealed that REST plays an important role in the development and disease of the nervous system, mainly by repressing the transcription of neuron-specific genes. Subsequently, REST was found to be critical in other tissues, such as the heart, pancreas, skin, eye, and vascular. Dysregulation of REST was also found in nervous and non-nervous system cancers. In parallel, multiple strategies to target REST have been developed. 
  • 353
  • 13 Nov 2023
Topic Review
Postharvest Diseases Management of Fruits and Vegetables
Sustainable agriculture requires factors to directly stimulate plant growth and induce the plant’s innate immune system to protect against stresses. Protection of plants is one of the main approaches to the supply of food resource. Furthermore, improved techniques for plant disease management must be environmentally sustainable, reliable, acceptable by society, and chemical-free to ensure sustainable food security. Although it is not possible to accurately determine postharvest losses due to diseases and physiological disorders, the use of proper harvesting and transportation methods that minimize damage to the product, along with optimal storage conditions that prevent the development of diseases, will be effective in reducing these postharvest losses. Since handling and storage conditions are potential threats for postharvest spoilage, it is necessary to identify environmentally friendly approaches and their precision mechanisms for postharvest disease management. Biological control, non-chemical, and eco-friendly techniques have been investigated for this purpose.
  • 237
  • 13 Nov 2023
Topic Review
Glutamate Receptor in Alzheimer’s and Parkinson’s Diseases
Glutamate excitotoxicity is a complex biological process that initiates when glutamate receptors are activated, leading to damage in dendrites and eventually causing cell death.
  • 348
  • 13 Nov 2023
Topic Review
Challenge of Global Warming in Water Buffalo Farming
Global warming (GW) is a current challenge for livestock systems, including water buffalo farms. Buffaloes have anatomical traits such as thick skin and a high density of capillaries and arterioles to improve sensitive heat losses. However, they are exposed to high temperatures and tropical and humid climates that make them susceptible to heat stress.
  • 436
  • 12 Nov 2023
Topic Review
Non-Peptide Neurokinin-1 Receptor Antagonists as Antitumor Drugs
The substance P (SP)/neurokinin-1 receptor (NK-1R) system is involved in cancer progression. NK-1R, activated by SP, promotes tumor cell proliferation and migration, angiogenesis, the Warburg effect, and the prevention of apoptosis. Tumor cells overexpress NK-1R, which influences their viability. A typical specific anticancer strategy using NK-1R antagonists, irrespective of the tumor type, is possible because these antagonists block all the effects mentioned above mediated by SP on cancer cells.
  • 417
  • 10 Nov 2023
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