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Topic Review
Avocado-Derived Biomass
The avocado (Persea americana Mill.) is a tree native to Mexico and Guatemala, and currently it is cultivated in more than 70 countries. Avocado consumption, fresh or in the form of processed products, is growing everywhere and it has caused a large number of countries to invest heavily in avocado production. The industrialization of avocado gives as a result a huge amount of waste: peel, stone, tree pruning, and oil extraction wastes. Although the industrial application of these biomasses is still limited, numerous studies suggest that they can serve as raw materials to obtain bioenergy and different types of bioproducts. To take full advantage of them, it would particularly interesting to develop biorefinery models.
  • 1.6K
  • 27 Dec 2020
Topic Review
Immune Checkpoint Inhibitor
Immunological checkpoint inhibitors (ICPI) are monoclonal antibodies that target the signaling pathways of the immune system that involve the programmed cell death protein 1 (PD-1), programmed cell death ligand 1 (PD-L1), and cytotoxic T-lymphocyte antigen 4 (CTLA-4) molecules, contributing to restore the immune responses against neoplastic cells.
  • 1.6K
  • 26 Oct 2020
Topic Review
HEK293 Cell Line
The HEK293 cell line has earned its place as a producer of biotherapeutics. In addition to its ease of growth in serum-free suspension culture and its amenability to transfection, this cell line’s most important attribute is its human origin, which makes it suitable to produce biologics intended for human use. At the present time, the growth and production properties of the HEK293 cell line are inferior to those of non-human cell lines, such as the Chinese hamster ovary (CHO) and the murine myeloma NSO cell lines. However, the modification of genes involved in cellular processes, such as cell proliferation, apoptosis, metabolism, glycosylation, secretion, and protein folding, in addition to bioprocess, media, and vector optimization, have greatly improved the performance of this cell line.
  • 1.6K
  • 07 Jul 2021
Topic Review
Extrusion Bioprinting for Skin Applications
Skin is a large and complex organ that serves protective and regulatory functions and is responsible for communication between the external environment and the inner organism. To fulfill these functions, skin has evolved as an organ with a complex anatomy derived from both the ectoderm (epidermis) and mesoderm (dermis). The skin includes not only these two major compartments but also important appendages, including hair follicles, sweat and sebaceous glands, nerve endings, and blood vessels, all of which have intricate spatial arrangements that render fabrication of the full skin organ challenging.
  • 1.6K
  • 26 Oct 2020
Topic Review
Bone ECM Signaling
Bone mineral density, a bone matrix parameter frequently used to predict fracture risk, is not the only one to affect bone fragility. Other factors, including the extracellular matrix (ECM) composition and microarchitecture, are of paramount relevance in this process. The bone ECM is a noncellular three-dimensional structure secreted by cells into the extracellular space, which comprises inorganic and organic compounds. The main inorganic components of the ECM are calcium-deficient apatite and trace elements, while the organic ECM consists of collagen type I and noncollagenous proteins. Bone ECM dynamically interacts with osteoblasts and osteoclasts to regulate the formation of new bone during regeneration. Thus, the composition and structure of inorganic and organic bone matrix may directly affect bone quality. Moreover, proteins that compose ECM, beyond their structural role have other crucial biological functions, thanks to their ability to bind multiple interacting partners like other ECM proteins, growth factors, signal receptors and adhesion molecules. Thus, ECM proteins provide a complex network of biochemical and physiological signals.
  • 1.6K
  • 17 Dec 2020
Topic Review
List of Fictional Crocodiles and Alligators
This is a list of fictional crocodiles and alligators from literature, folklore and myth, mascots and emblems of teams and organizations, comics, films, animations and video games. This list is subsidiary to the list of fictional animals. It is restricted to notable crocodilian characters from notable works of fiction. Characters that appear in multiple media may have separate listings for each appearance, while in instances where a character has appeared in several separate works in a single medium, only the earliest will be recorded here.
  • 1.6K
  • 21 Oct 2022
Topic Review
Ring-Tailed Cat
The ringtail (Bassariscus astutus) is a mammal of the raccoon family native to arid regions of North America. It is widely distributed and well adapted to disturbed areas. It has been legally trapped for its fur. It is listed as Least Concern on the IUCN Red List. It is also known as the ringtail cat, ring-tailed cat, miner's cat or bassarisk, and is sometimes called a cacomistle, though this term seems to be more often used to refer to Bassariscus sumichrasti.
  • 1.6K
  • 14 Oct 2022
Topic Review
List of R1a Frequency by Population
Haplogroup R1a is one of the major classifications (called clades) of Y-chromosome types found in human male lines. It is widespread all across Eurasia. Many sample studies therefore carry information on the incidence of R1a and/or its subclassifications, in particular the dominant branching line represented by the haplogroups R1a1 and R1a1a. The table below collates information from a number of such sample studies, with incidence frequencies in sample data reported as percentages, along with the associated sample sizes.
  • 1.6K
  • 09 Nov 2022
Topic Review
Green Seaweeds and Ulvan
This entry analyzed the recent trend towards, progresses towards the preparation of chemicals of, and value-added biomaterials from marine macroalgae resources, especially green seaweeds and their derived ulvan polysaccharides for various applications. In recent years, ulvan both in pristine and modified forms has gained a large amount of attention for its effective utilization in various areas due to its unique physiochemical properties, lack of exploration, and higher green seaweed production. The pristine form of ulvan (sulfated polysaccharides) is used as a bio-component; food ingredient; or a raw material for the production of numerous chemicals such as fuels, cosmetics, and pharmaceuticals, whereas its modified form is used in the sector of composites, membranes, and scaffolds, among others, because of its physicochemical properties.
  • 1.6K
  • 15 Jun 2021
Topic Review
Wheat Blast and Food Security
Wheat blast is a fearsome fungal disease caused by a filamentous fungus, Magnaporthe oryzae Triticum pathotype. It was first detected in Brazil in 1985, then it spread to some neighboring South American countries such as Bolivia, Argentina and Paraguay. The outbreak of wheat blast was spotted in Bangladesh for the first time in 2016, which devastated 15,000 hectares of wheat with yield losses up to 100%. Recently, it was detected in Zambia (an African country). The disease spreads through seeds and airborne conidia. There is no resistant variety against wheat blast disease. Once the disease symptoms are expressed as the bleached or partially bleached spikes, fungicide application is ineffective to control it. A convenient and rapid molecular diagnostic tool is developed for surveillance and monitoring of the wheat blast. However, our understanding the biology of wheat blast fungus and its interactions with the host plant is limited. A globally concerted effort is needed to develop durable blast-resistant varieties to combat this killer of wheat before the spread to major wheat growing countries in the world.
  • 1.6K
  • 23 Oct 2020
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