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Topic Review
TP53 Pathway in Embryonic/Somatic Cells
The P53 pathway is the most important cellular pathway to maintain genomic and cellular integrity, both in embryonic and non-embryonic cells. Stress signals induce its activation, initiating autophagy or cell cycle arrest to enable DNA repair.
  • 665
  • 03 Jun 2021
Topic Review
TP53 in Germ Cell Tumours
The cure rate of germ cell tumours (GCTs) has significantly increased from the late 1970s since the introduction of cisplatin-based therapy. The exquisite cisplatin sensitivity has been mainly explained by the over-expression in GCTs of wild-type TP53 protein and the lack of TP53 somatic mutations; however, several other mechanisms seem to be involved, many of which remain still elusive. The findings about the role of TP53 in platinum-sensitivity and resistance, as well as the reported evidence of second cancers (SCs) in GCT patients treated only with surgery, suggesting a spectrum of cancer predisposing syndromes, highlight the need for a deepened understanding of the role of TP53 in GCTs. 
  • 524
  • 27 Jul 2021
Topic Review
TP53 Gene
Tumor protein p53: The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53).
  • 694
  • 25 Dec 2020
Topic Review
TP53 and Testicular Germ Cell Tumors
Germ cell tumors (GCTs) are the most common solid malignancies in young men. Despite the high frequency of these cancers within this defined age group, the discovery of the exceptional sensitivity of these tumors to the platinum DNA crosslinking compound cisplatin has led to the survival of most patients, with the current five-year survival rate exceeding 95%.
  • 461
  • 05 Nov 2021
Topic Review
TP53
TP53 tumor suppressor gene is a key player for cellular homeostasis.
  • 515
  • 02 Feb 2021
Topic Review
Toxungen
A toxungen comprises a secretion or other body fluid of one or more biological toxins that is transferred by one animal to the external surface of another animal via a physical delivery mechanism. Toxungens can be delivered through spitting, spraying, or smearing. As one of three categories of biological toxins, toxungens can be distinguished from poisons, which are passively transferred via ingestion, inhalation, or absorption across the skin, and venoms, which are delivered through a wound generated by a bite, sting, or other such action. Toxungen use offers the evolutionary advantage of delivering toxins into the target's tissues without the need for physical contact.
  • 385
  • 28 Aug 2023
Topic Review
Toxoplasma gondii-Induced and Associated Diseases
Toxoplasma gondii (T. gondii) is a prevalent protozoan parasite of medical and veterinary significance. It is the etiologic agent of toxoplasmosis, a neglected disease in which incidence and symptoms differ between patients and regions. In immunocompetent patients, toxoplasmosis manifests as acute and chronic forms. Acute toxoplasmosis presents as mild or asymptomatic disease that evolves, under the host immune response, into a persistent chronic disease in healthy individuals. Chronic toxoplasmosis establishes as latent tissue cysts in the brain and skeletal muscles. In immunocompromised patients, chronic toxoplasmosis may reactivate, leading to a potentially life-threatening condition. 
  • 1.1K
  • 05 Nov 2021
Topic Review
Toxoplasma gondii Oocysts
Toxoplasmosis is a zoonotic parasitic disease caused by the protozoan Toxoplasma gondii (T. gondii;).
  • 367
  • 09 Mar 2021
Topic Review
Toxoplasma gondii Infections in Southern Africa
Toxoplasma gondii is an apicomplexan parasite with zoonotic importance worldwide especially in pregnant women and immunocompromised people. There is limited information on the distribution of T. gondii in animals and humans in southern African countries. The overall pooled prevalence is estimated as 17%.
  • 494
  • 17 Mar 2022
Topic Review
Toxoplasma gondii in Marine Life of Italian Coasts
Coastal areas of Italy experience high anthropogenic pressure, with a population density estimated to be 360 people per km2. This is correlated with the production of sewage or surface runoff of water contaminated with Toxoplasma gondii oocysts and other pathogens that can in turn enter the food chain and become a public health concern.
  • 287
  • 25 Dec 2023
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