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Biography
Bahá'u'lláh
Bahá'u'lláh (Arabic: بهاء الله; 12 November 1817 – 29 May 1892), was a Persian religious leader and the founder of the Bahá'í Faith, which advocates universal peace and unity among all races, nations, and religions. At the age of 27, Bahá'u'lláh became a follower of the Báb, a Persian merchant who began preaching that God would soon send a new prophet similar to Jesus or Muham
  • 2.2K
  • 06 Dec 2022
Topic Review
Bifidobacteria
Bifidobacteria are high G+C Gram positive bacteria belonging to the Actinobacteria phylum isolated from the gastrointestinal tract of different mammals, birds and social insects.
  • 2.2K
  • 11 Jan 2021
Topic Review
Cutibacterium acnes
Cutibacterium acnes is a member of the skin microbiota found predominantly in regions rich in sebaceous glands. It is involved in maintaining healthy skin and has long been considered a commensal bacterium. Its involvement in various infections has led to its emergence as an opportunist pathogen. Interactions between C. acnes and the human host, including the human skin microbiota, promote the selection of C. acnes strains capable of producing several virulence factors that increase inflammatory capability. This pathogenic property may be related to many infectious mechanisms, such as an ability to form biofilms and the expression of putative virulence factors capable of triggering host immune responses or enabling C. acnes to adapt to its environment. During the past decade, many studies have identified and characterized several putative virulence factors potentially involved in the pathogenicity of this bacterium. These virulence factors are involved in bacterial attachment to target cells, polysaccharide-based biofilm synthesis, molecular structures mediating inflammation, and the enzymatic degradation of host tissues. C. acnes, like other skin-associated bacteria, can colonize various ecological niches other than skin. It produces several proteins or glycoproteins that could be considered to be active virulence factors, enabling the bacterium to adapt to the lipophilic environment of the pilosebaceous unit of the skin, but also to the various organs it colonizes. 
  • 2.2K
  • 22 Sep 2021
Topic Review
Intracellular Organelles
Viruses have evolved different strategies to hijack subcellular organelles during their life cycle to produce robust infectious progeny. Successful viral reproduction requires the precise assembly of progeny virions from viral genomes, structural proteins, and membrane components. Such spatial and temporal separation of assembly reactions depends on accurate coordination among intracellular compartmentalization in multiple organelles. Virus trigger the rearrangement and morphology remodeling of intracellular organelles, including the quality control of intracellular organelles, the hijacking of the modified organelle membranes, morphology remodeling for viral replication, and degradation of intracellular organelles by virus-triggered selective autophagy.
  • 2.2K
  • 27 Oct 2020
Topic Review
Anti-Aging Potentials of Methylene Blue
Methylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. Apart from its well-known applications in surgical staining, malaria, and methemoglobinemia, the anti-oxidative properties of MB recently brought new attention to this century-old drug. Mitochondrial dysfunction has been observed in systematic aging that affects many different tissues, including the brain and skin. This leads to increased oxidative stress and results in downstream phenotypes under age-related conditions. MB can bypass Complex I/III activity in mitochondria and diminish oxidative stress to some degree. MB also shows broad spectrum UV absorption capability.
  • 2.2K
  • 13 Dec 2021
Topic Review
Role of ABA in Plant Growth
Abscisic acid (ABA) regulates various aspects of plant physiology, including promoting seed dormancy and adaptive responses to abiotic and biotic stresses. Growth regulation by ABA is both promotive and inhibitive, depending on the context, such as concentrations, tissues, and environmental conditions. 
  • 2.2K
  • 09 Feb 2022
Topic Review
N-Acetylcysteine
Exercise frequently alters the metabolic processes of oxidative metabolism in athletes, including exposure to extreme reactive oxygen species impairing exercise performance. Therefore, both researchers and athletes have been consistently investigating the possible strategies to improve metabolic adaptations to exercise-induced oxidative stress. N-acetylcysteine (NAC) has been applied as a therapeutic agent in treating many diseases in humans due to its precursory role in the production of hepatic glutathione, a natural antioxidant.
  • 2.2K
  • 03 Feb 2021
Topic Review
CRISPR Therapeutics
The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) genome editing system has been the focus of intense research in the last decade due to its superior ability to desirably target and edit DNA sequences. The applicability of the CRISPR-Cas system to in vivo genome editing has acquired substantial credit for a future in vivo gene-based therapeutic. Challenges such as targeting the wrong tissue, undesirable genetic mutations, or immunogenic responses, need to be tackled before CRISPR-Cas systems can be translated for clinical use. Hence, there is an evident gap in the field for a strategy to enhance the specificity of delivery of CRISPR-Cas gene editing systems for in vivo applications. Current approaches using viral vectors do not address these main challenges and, therefore, strategies to develop non-viral delivery systems are being explored. Peptide-based systems represent an attractive approach to developing gene-based therapeutics due to their specificity of targeting, scale-up potential, lack of an immunogenic response and resistance to proteolysis. In this review, we discuss the most recent efforts towards novel non-viral delivery systems, focusing on strategies and mechanisms of peptide-based delivery systems, that can specifically deliver CRISPR components to different cell types for therapeutic and research purposes.
  • 2.2K
  • 12 Oct 2020
Topic Review
Black Tiger (Animal)
A black tiger is a rare colour variant of the tiger and is not a distinct species or geographic subspecies.
  • 2.2K
  • 18 Oct 2022
Topic Review
Mapping Paddy Rice with Remote-Sensing
Paddy rice is a staple food of three billion people in the world. Timely and accurate estimation of the paddy rice planting area and paddy rice yield can provide valuable information for the gov-ernment, planners and decision makers to formulate policies.
  • 2.2K
  • 14 Jan 2022
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