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Topic Review
Airway Structural Changes in Asthma
Increased airway wall thickness and remodeling of bronchial mucosa are characteristic of asthma and may arise from altered integrin signaling on airway cells. Here, we analyzed the expression of β1-subfamily integrins on blood and airway cells (flow cytometry), inflammatory biomarkers in serum and bronchoalveolar lavage, reticular basement membrane (RBM) thickness and collagen deposits in the mucosa (histology), and airway geometry (CT-imaging) in 92 asthma patients (persistent airflow limitation subtype: n=47) and 36 controls. Persistent airflow limitation was associated with type-2 inflammation, elevated soluble α2 integrin chain, and changes in the bronchial wall geometry. Both subtypes of asthma showed thicker RBM than control, but collagen deposition and epithelial α1 and α2 integrins staining were similar. Type-I collagen accumulation and RBM thickness were inversely related to the epithelial expression of the α2 integrin chain. Expression of α2β1 integrin on T-cells and eosinophils was not altered in asthma. Collagen I deposits were, however, more abundant in patients with lower α2β1 integrin on blood and airway CD8+ T-cells. Thicker airway walls in CT were associated with lower α2 integrin chain on blood CD4+ T-cells and airway eosinophils. Our data suggest that α2β1 integrin on inflammatory and epithelial cells may protect against airway remodeling advancement in asthma.
  • 573
  • 30 Sep 2021
Biography
Ajahn Brahm
Phra Visuddhisamvarathera AM, known as Ajahn Brahmavaṃso, or simply Ajahn Brahm (born Peter Betts[1] on 7 August 1951), is a British-Australian Theravada Buddhist monk. Currently Ajahn Brahm is the Abbot of Bodhinyana Monastery, in Serpentine, Western Australia, Spiritual Adviser to the Buddhist Society of Victoria, Spiritual Adviser to the Buddhist Society of South Australia, Spiritual Patron
  • 1.2K
  • 14 Nov 2022
Topic Review
Akhirin
The structure of AKH comprises two von Willebrand factor-A (vWF-A) domains and one Limulus factor C, Coch-5b2 and Lgl1 (LCCL) domain. The chick AKH has an open reading frame of 748 amino acid residues, and the mouse AKH has an open reading frame of 650 amino acid residues (A). AKH has relatively high homology to vitrinand cochlin.
  • 461
  • 22 Sep 2021
Topic Review
Akkermansia muciniphila
Akkermansia muciniphila is one of the early occupants (in first year of life) of the intestinal tract with 108 cell/gm or more than 1% of total faecal microbes.
  • 1.1K
  • 05 Aug 2021
Topic Review
AKR1B10
Preventing the cytokine storm observed in COVID-19 is a crucial goal for reducing the occurrence of severe acute respiratory failure and improving outcomes. The analysis of transcriptomic data from lung samples of patients who died from COVID-19 demonstrates an increased expression of the gene encoding AKR1B10.
  • 394
  • 23 Feb 2022
Topic Review
AKR1B10 in Physiology and Pathophysiology
AKR1B10 is a human nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductase belonging to the aldo-keto reductase (AKR) 1B subfamily. It catalyzes the reduction of aldehydes, some ketones and quinones, and interacts with acetyl-CoA carboxylase and heat shock protein 90α. The enzyme is highly expressed in epithelial cells of the stomach and intestine, but down-regulated in gastrointestinal cancers and inflammatory bowel diseases. In contrast, AKR1B10 expression is low in other tissues, where the enzyme is upregulated in cancers, as well as in non-alcoholic fatty liver disease and several skin diseases. In addition, the enzyme’s expression is elevated in cancer cells resistant to clinical anti-cancer drugs. Thus, growing evidence supports AKR1B10 as a potential target for diagnosing and treating these diseases. Herein, we reviewed the literature on the roles of AKR1B10 in a healthy gastrointestinal tract, the development and progression of cancers and acquired chemoresistance, in addition to its gene regulation, functions, and inhibitors.
  • 421
  • 24 Jun 2021
Topic Review
AKT1 Gene
AKT serine/threonine kinase 1
  • 567
  • 24 Dec 2020
Topic Review
AKT3 Gene
AKT serine/threonine kinase 3
  • 379
  • 24 Dec 2020
Topic Review
Alagille Syndrome
Alagille syndrome is a genetic disorder that can affect the liver, heart, and other parts of the body.
  • 481
  • 31 Dec 2020
Biography
Alan Abramowitz
Alan Ira Abramowitz (born December 1, 1947)[1] is an United States political scientist and author, known for his research and writings on American politics, elections, and political parties in political science. Abramowitz graduated with a B.A. with high honors in political science from the University of Rochester in 1969. He attended graduate school at Stanford University, completing an M.A.
  • 485
  • 27 Dec 2022
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