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Topic Review
Achondrogenesis
Achondrogenesis is a group of severe disorders that affect cartilage and bone development. These conditions are characterized by a small body, short limbs, and other skeletal abnormalities. As a result of serious health problems, infants with achondrogenesis usually die before birth, are stillborn, or die soon after birth from respiratory failure. However, some infants have lived for a short time with intensive medical support.
  • 500
  • 23 Dec 2020
Topic Review
Achondroplasia
Achondroplasia is a form of short-limbed dwarfism. The word achondroplasia literally means "without cartilage formation." Cartilage is a tough but flexible tissue that makes up much of the skeleton during early development. However, in achondroplasia the problem is not in forming cartilage but in converting it to bone (a process called ossification), particularly in the long bones of the arms and legs. Achondroplasia is similar to another skeletal disorder called hypochondroplasia, but the features of achondroplasia tend to be more severe.
  • 566
  • 23 Dec 2020
Topic Review
Achromatopsia
Achromatopsia is a condition characterized by a partial or total absence of color vision. People with complete achromatopsia cannot perceive any colors; they see only black, white, and shades of gray. Incomplete achromatopsia is a milder form of the condition that allows some color discrimination.
  • 365
  • 23 Dec 2020
Topic Review
Acid and Alkali Taste Sensation
Living organisms rely on pH levels for a multitude of crucial biological processes, such as the digestion of food and the facilitation of enzymatic reactions. Among these organisms, animals, including insects, possess specialized taste organs that enable them to discern between acidic and alkaline substances present in their food sources.
  • 362
  • 15 Nov 2023
Topic Review
Acid-Sensing Ion Channels and Mechanosensation
Acid-sensing ion channels (ASICs) are mainly proton-gated cation channels, which can be activated by a drop in extracellular pH below 7.0 and triggered by nonproton ligands during physiological pH levels.
  • 500
  • 12 May 2021
Topic Review
Acid-Sensing Ion Channels in Glial Cells
Acid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to neuronal injury. ASICs exhibit unique patterns of distribution in the brain, with high expression in neurons and low expression in glial cells. While there has been a lot of focus on ASIC in neurons, less is known about the roles of ASICs in glial cells. ASIC1a is expressed in astrocytes and might contribute to synaptic transmission and long-term potentiation. In oligodendrocytes, constitutive activation of ASIC1a participates in demyelinating diseases. ASIC1a, ASIC2a, and ASIC3, found in microglial cells, could mediate the inflammatory response. Under pathological conditions, ASIC dysregulation in glial cells can contribute to disease states. For example, activation of astrocytic ASIC1a may worsen neurodegeneration and glioma staging, activation of microglial ASIC1a and ASIC2a may perpetuate ischemia and inflammation, while oligodendrocytic ASIC1a might be involved in multiple sclerosis.
  • 383
  • 08 Feb 2022
Topic Review
Acid-Sensing Ion Channels in Zebrafish
Acid-sensing ion channels (ASICs) are Na+channels gated by extracellular H+and are widely expressed in the mammalian central and peripheral nervous systems. ASICs are part of the degenerin/epithelial sodium (Na) channel (DEG/ENaC) superfamily whose feature is high permeability to Na that could be blocked by amiloride. Structurally, ASICs consist of two hydrophobic transmembrane domains (TMD) of 20 amino acids approximately, TMD1 and TMD2, a large domain of around 370 amino acids forming an extracellular loop of 14 conserved cysteines, and a kind of short cytoplasmic amino and carboxyl termini of 35–90 amino acids.
  • 662
  • 01 Sep 2021
Topic Review
Acidobacteria
Acidobacteria is a phylum of bacteria. Its members are physiologically diverse and ubiquitous, especially in soils, but are under-represented in culture.
  • 1.0K
  • 29 Nov 2022
Topic Review
Acinar Cells for Pancreatic Cancer
The carcinogenesis of pancreatic ductal adenocarcinoma (PDA) progresses according to multi-step evolution, whereby the disease acquires increasingly aggressive pathological features. Lineage-tracing experiments demonstrated that pancreatic cancerous lesions originate from acinar cells, a highly specialized cell type in the pancreatic epithelium. Acinar cells are polarized, pyramidal-shaped cells containing numerous acidophilic granules near the apical side. Those granules contain inactive proteases, which are activated and released into the tubular network upon activation. Primary acinar cells can survive in vitro as organoid-like 3D spheroids, which can transdifferentiate into cells with a clear ductal morphology in response to different cell- and non-cell-autonomous stimuli.This event, termed acinar-to-ductal metaplasia, recapitulates the histological and molecular features of disease initiation.
  • 2.6K
  • 24 Sep 2020
Topic Review
Acinar-to-Ductal Metaplasia and Transcription Factors Involved
Pancreatic acinar-to-ductal metaplasia (ADM) is a cellular process in which the differentiated pancreatic acinar cells transform into duct-like cells. This process can occur as a result of cellular injury or inflammation in the pancreas. While ADM is a reversible process allowing pancreatic acinar regeneration, persistent inflammation or injury can lead to the development of pancreatic intraepithelial neoplasia (PanIN), which is a common precancerous lesion that precedes pancreatic ductal adenocarcinoma (PDAC).
  • 446
  • 19 Jun 2023
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